International Journal of Celiac Disease
ISSN (Print): 2334-3427 ISSN (Online): 2334-3486 Website: http://www.sciepub.com/journal/ijcd Editor-in-chief: Samasca Gabriel
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International Journal of Celiac Disease. 2019, 7(1), 16-20
DOI: 10.12691/ijcd-7-1-8
Open AccessArticle

Neurological Complications of Coeliac Disease

Justyna Chojdak-Łukasiewicz1, , Edyta Dziadkowiak1, Małgorzata Błauciak1 and Bogusław Paradowski1

1Department of Neurology, Wrocław Medical University, st. Borowska 213, 50-556 Wrocław

Pub. Date: March 08, 2019

Cite this paper:
Justyna Chojdak-Łukasiewicz, Edyta Dziadkowiak, Małgorzata Błauciak and Bogusław Paradowski. Neurological Complications of Coeliac Disease. International Journal of Celiac Disease. 2019; 7(1):16-20. doi: 10.12691/ijcd-7-1-8

Abstract

Coeliac disease (CD) is a chronic autoimmune enteropathy of the small intestine that occurs in genetically predisposed individuals. It is characterized by atrophy of intestinal villi accompanied by an increase in the number of intraepithelial lymphocytes and crypt hypertrophy as well as the presence of specific endomysial antibodies (EMA), IgA tissue transglutaminase antibodies (IgA-tTG), and IgA and IgG deaminated gliadin peptide antibodies (DGP IgA and IgG). CD is associated with a wide spectrum of clinical signs and symptoms secondary to malabsorption (vitamin deficiency, anaemia, osteoporosis) or unrelated to the gastrointestinal tract. Neurological disorders are a common problem in patients with CD and are not always accompanied by gastrointestinal symptoms. The most common neurological manifestations of CD are cerebellar ataxia, epilepsy, and peripheral neuropathy.

Keywords:
coeliac disease gluten ataxia neuropathy gluten

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