American Journal of Educational Research
ISSN (Print): 2327-6126 ISSN (Online): 2327-6150 Website: Editor-in-chief: Ratko Pavlović
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American Journal of Educational Research. 2021, 9(3), 117-124
DOI: 10.12691/education-9-3-5
Open AccessReview Article

Thrombosis in Covid-19 Patients and Dilemma of Antithrombotic Choice: A Systematic Review

Nso Nso1, , Mahmoud Nassar1, Gilbert Ojong2, Akwe Nyabera1, Sofia Lakhdar1, Mohsen Alshamam1, Somtochukwu Nwokoye3, Matthew Li1, Mostafa Alfishawy4 and Debra J. Brennessel1

1Internal Medicine, Icahn School of Medicine, Mount Sinai/NYC Health Hospital, Queens, New York.

2Department of Internal Medicine, La Magna Health/United Regional Hospital

3Augusta University-University of Georgia Medical Partnership, St. Mary's Hospital

43Augusta University-University of Georgia Medical Partnership, St. Mary's Hospital

Pub. Date: March 25, 2021

Cite this paper:
Nso Nso, Mahmoud Nassar, Gilbert Ojong, Akwe Nyabera, Sofia Lakhdar, Mohsen Alshamam, Somtochukwu Nwokoye, Matthew Li, Mostafa Alfishawy and Debra J. Brennessel. Thrombosis in Covid-19 Patients and Dilemma of Antithrombotic Choice: A Systematic Review. American Journal of Educational Research. 2021; 9(3):117-124. doi: 10.12691/education-9-3-5


Background: Coronavirus Disease 2019 (COVID-19) potentially deteriorates the immune system and triggers prothrombotic states in many patient scenarios. Clinical studies so far do not stratify the risk of thromboembolism in COVID-19 cases. Objective: This systematic review investigates the risks of thromboembolism and outcomes of anticoagulation therapy in COVID-19 patients. Methods: We searched PubMed, Cochrane Library, Embase, Web of Science, and Google Scholar to identify relevant studies assessing thromboembolism and anticoagulant therapy in COVID-19 patients. Study Selection, Data Extraction, and Synthesis: Two reviewers screened the titles and abstracts of the included studies in the context of COVID-19, thrombosis, and anticoagulant therapy. The reviewers also ascertained the elimination of duplicate articles. Results: We included eight studies based on the thromboembolism predisposition of COVID-19 (adult/elderly) patients with the status/history of cardiovascular disease, diabetes, hypertension, obesity, and hospital admission. Conclusion: Prospective studies need to explore the risks of thromboembolism in patients with COVID-19. The current body of evidence does not substantiate antithrombotic treatment for managing thromboembolism in the setting of COVID-19. The physicians must take preventive measures for reducing the incidence rate of thromboembolism in COVID-19 scenarios until the availability of definitive treatment.

thromboses COVID-19 anticoagulants incidence SARS-CoV-2

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