Evaluation of the Activity of Crude Alkaloids Extracts of Zingiber officinale Roscoe., Thymus vulgaris L. and Acacia arabica L. as Coagulant Agent in Lab Mice

AyyadWajeeh Raaof^1, , Zahraa Abdul-Elah Al-Naqqash², Abdul-Latif M. Jawad¹ and Salah M. Muhsan³

¹Department of Biology, College of Science, Baghdad University, Baghdad, Iraq

²College of Pharmacy, Al-Mustansyria University, baghdad, Iraq

³Biotechnology research center, Al.Nahrain University, Baghdad, Iraq

Cite this paper:
AyyadWajeeh Raaof, Zahraa Abdul-Elah Al-Naqqash, Abdul-Latif M. Jawad and Salah M. Muhsan. Evaluation of the Activity of Crude Alkaloids Extracts of Zingiber officinale Roscoe., Thymus vulgaris L. and Acacia arabica L. as Coagulant Agent in Lab Mice. Biomedicine and Biotechnology. 2013; 1(2):11-16. doi: 10.12691/bb-1-2-3

Abstract

As Alkaloids known for their pharmaceutical importance; this research included the extraction of crude alkaloids of three plants (Zingiberofficinale Roscoe, Thymus vulgaris L. and Acaciaarabica L.) and evaluate their activity as coagulant agent by using three degraded concentrations of each plant extract and tested them on lab mice through the observation of the variations in bleeding time(BT), clotting time(CT), platelet, red blood cells(RBC), packed cell volume(PCV), white blood cells (WBC) and hemoglobin counts(Hb) with Calcium count (Ca) in blood. The results revealed differences in the percentage of alkaloids in the plants under the study; Zingiber was the higher one followed by Thymus and Acacia respectively.Zingiberwas also the most effective plant as coagulant factor than other two plants as it decreased both BT and CT and increased platelets, RBC, PCV, WBC and Ca count. more than what T. vulgaris and A. arabica affected on blood characters mentioned before.

Keywords:
alkaloids coagulant agent bleeding time clotting time platelets blood cells packed cell volume white blood cells hemoglobin and calcium counts

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