American Journal of Sports Science and Medicine
ISSN (Print): 2333-4592 ISSN (Online): 2333-4606 Website: http://www.sciepub.com/journal/ajssm Editor-in-chief: Ratko Pavlović
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American Journal of Sports Science and Medicine. 2013, 1(3), 42-46
DOI: 10.12691/ajssm-1-3-3
Open AccessReview Article

Overview of Lactate Metabolism and the Implications for Athletes

Aldeam Facey1, , Rachael Irving1 and Lowell Dilworth2

1Department of Basic Medical Sciences, Biochemistry Section the University of the West Indies Mona Campus

2Department of Pathology, the University of the West Indies Mona Campus

Pub. Date: September 21, 2013

Cite this paper:
Aldeam Facey, Rachael Irving and Lowell Dilworth. Overview of Lactate Metabolism and the Implications for Athletes. American Journal of Sports Science and Medicine. 2013; 1(3):42-46. doi: 10.12691/ajssm-1-3-3

Abstract

Lactate metabolism is an integral pathway in physical exercise. Numerous contrasting views exist regarding the physiological effects of lactate and its roles post production. This paper attempts to clarify and highlight the significance of lactate in exercise. Lactate production is associated with muscular fatigue; and is a major limitation in athletic performance. This fatigue is partially due to the production of H+ ions which depresses muscle functions. Lactate is transported in the skeletal muscles through plasma monocarboxylate transport (MCT) system and is utilized by muscles such as the heart and red muscles. It is also very important that the lactate produced to satisfy high energy demands is cleared from the muscles and metabolized by the liver or be utilized as an energy substrate. There is a marked positive correlation existing between adiposity and lactate production. Numerous physiological properties inclusive of adiposity, VO2 max, lactate threshold and insulin sensitivity affect and regulate lactate production.

Keywords:
hypoxia lactate adiposity VO2 max metabolism athletes

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References:

[1]  Armstrong, R.B, “Muscle fiber recruitment patterns and their metabolic correlates,” Exercise, Nutrition, and Energy Metabolism, 9-26. 1998.
 
[2]  Baker, J.S., McCormick, M.C. & Robergs, R.A, “Interaction among Skeletal Muscle Metabolic Energy Systems during Intense Exercise,” Journal of Nutrition and Metabolism 2010: Article ID 905612, 13 pages.
 
[3]  Balsom, P.D., Gaitanos, G.C., Ekblom, B. & Sjodin, B, “Reduced oxygen availability during high intensity intermittent exercise impairs performance,” Acta Physiologica Scandinavica, 152 (3). 279-285. 1994.
 
[4]  Chatham, J.C, “Lactate – the forgotten fuel!,” The Journal of Physiology, 542(2). 333. 2002.
 
[5]  Crandall, D.L., Fried, S.K., Francendese, A.A., Nickel, M. & DiGirolamo, M. “Lactate release from isolated rat adipocytes: influence of cell size, glucose concentration, insulin and epinephrine,” Horm. MetaboL Res, 15. 326-329. 1983.
 
[6]  DiGirolamo, M., Newby, F.D. & Lovejoy, J, “Lactate production in adipose tissue: a regulated function with extra-adipose implications,” The FACEB Journal, 6(7). 2405-2412. 1992.
 
[7]  Gillium, T.L. & Kravitz, L, “Assessing the lactate threshold,” IDEA Fitness Journal, 5(2). 21-23. 2008.
 
[8]  Gladden, L. B, “Lactate metabolism: a new paradigm for the third millennium,” The Journal of Physiology, 558. 5-30. 2004.
 
[9]  Gladden, L. B, “Muscle as a consumer of lactate,” Medicine & Science in Sports & Exercise, 32(4). 764-771. 2000.
 
[10]  Greenhaff, P.L., Nevill, M.E., Soderlund, K., Bodin, K., Boobis, L.H., Williams, C. & Hultman, E, “The metabolic responses of human type I and II muscle fibres during maximal treadmill sprinting” Journal of Physiology, 478 (1). 149-155. 1994.
 
[11]  Hall, G. V, “Lactate as a fuel for mitochondrial respiration,” Acta Physiologica Scandinavica, 168(4). 643-656. April.2000.
 
[12]  Hamann, J.J., Kelly, K.M. & Gladden, L.B, “Effect of epinephrine on net lactate uptake by contracting skeletal muscle,” Journal of Applied Physiology, 91. 2635-2641. 2001.
 
[13]  Hargreaves, M., McKenna, M.J., Jenkins, D.G., Warmington, S.A., Li, J.L., Snow, R.J. & Febbraio, M.A, “Muscle metabolites and performance during high-intensity, intermittent exercise,” Journal of Applied Physiology, 24. 1687-1691. 1998.
 
[14]  Hogan, M.C., Gladden, L.B., Kurdak, S.S. & Poole, D.C, “Increased [Lactate] in working dog muscle reduces tension development independent of pH,” MedSci Sports Exerc, 27. 371-377. 1995.
 
[15]  Jansson, E., Esbjörnsson, M., Holm, I. & Jacobs, I, “Increase in the proportion of fast-twitch muscle fibres by sprint training in males,” Acta Physiologica Scandinavica, 140(3). 359-363. 1990.
 
[16]  Jansson, P.A., Larsson, A., Smith, U. & Lönnroth, P, “Lactate release from the subcutaneous tissue in lean and obese men,” Journal for Clinical Investigation, 93(1). 240-246. 1994.
 
[17]  Juel. C. & Halestrap. A.P, “Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter,” Journal of Physiology, 517(3), 633-642. 1999.
 
[18]  Kemppainen, J., Fujimoto, T., Kalliokoski, K.K., Viljanen, T., Nuutila, P. & Knuuti, J, “Myocardial and skeletal muscle glucose uptake during exercise in humans,” The Journal of Physiology, 542(2). 403-412. 2002.
 
[19]  Lovejoy, J., Newby, F.D., Gebhart, S.S. & DiGirolamo, M, “Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin,” Metabolism, 41(1). 22-27. 1992.
 
[20]  Marcinik, E.J., Plotts, J., Schlabach, G., Will, S., Dawson, P. & Hurley, B.F, “Effects of strength training on lactate threshold and endurance performance,” Medicine and Science in Sports and Exercise, 23(6). 739-743. 1991.
 
[21]  Medbo, J.I. & Tabata, I. “Relative importance of aerobic and anaerobic energy release during short-lasting exhausting bicycle exercise,” Journal of Applied Physiology, 67 (5). 1881–1886. 1989.
 
[22]  Metz, L., Mercier, J., Tremblay, A., Alme´ras, N., & Joanisse, D.R, “Effect of weight loss on lactate transporter expression in skeletal muscle of obese subjects,” Journal of Applied Physiology, 104. 633-638. 2008.
 
[23]  Passarella, S., Bari, L., Valenti, D., Pizzuto, R., Paventi, G., & Atlante, A, “Mitochondria and l-lactate metabolism,” FEBS Letters, 582(25). 3569-3576. Oct.2008.
 
[24]  Pellerin, L., & Magistretti, P. J, “Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization” PNAS, 91(22). 10625-10629. Oct.1994.
 
[25]  Pilegaard, H., Domino, K., Noland, T., Juel, C., Hellsten, Y., Halestrap, AP., & Bangsbo J, “Effect of highintensity exercise training on lactate/H+ transport capacity in human skeletal muscle,” American Journal of Physiology, 276 (2). 255-261. 1999.
 
[26]  Posterino, G.S., Dutka, T.L., & Lamb, G.D, “L (+) - lactate does not affect twitch and tetanic responses in mechanically skinned mammalian muscle fibres,” Pflugers Arch, 442. 197-203. 2001.
 
[27]  Robergs, R.A., Ghiasvand, F., & Parker, D. “Biochemistry of exercise-induced metabolic acidosis,” Am J Physiol Regul Integr Comp Physiol, 287. 502-516. 2004.
 
[28]  Rogers, M.A., Hagberg, J.M., Martin, W.H., Ehsani, A.A. & Holloszy, J.O, “Decline in VO2max with aging in master athletes and sedentary men,” Journal of Applied Physiology, 68(1). 2195-2199. 1990.
 
[29]  Sahlin, K. & Ren, J.M., “Relationship of contraction capacity to metabolic changes during recovery from a fatiguing contraction,” Journal of Applied Physiology, 67. 648-654. 1989.
 
[30]  Schurr, A, “Lactate, glucose and energy metabolism in the ischemic brain (Review),” International Journal of Molecular Medicine, 10. 131-136. 2002.
 
[31]  Schurr, A, “Lactate: the ultimate cerebral oxidative energy substrate?” Journal of Cerebral Blood Flow & Metabolism, 26. 142-152. 2006.
 
[32]  Skinner, J.S., Wilmore, K.M. & Krasnoff, J.B, “Adaptation to a standardized training program and changes in fitness in a large, heterogeneous population: the heritage Family Study,” Medicine and Science in Sports and exercise, 32(1). 157-161. 2000.
 
[33]  Walter, G., Vandenborne, K., McCully, K.K. & Leigh, J.S, “Noninvasive measurement of phosphocreatine recovery kinetics in single human muscles,” American Journal of Physiology, 272 (2). 525-534. 1997.
 
[34]  Westerblad, H., Allen, D.G. & Lännergren, J, “Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?” Physiology, 17. 17-21. 2002.