American Journal of Pharmacological Sciences
ISSN (Print): 2327-6711 ISSN (Online): 2327-672X Website: Editor-in-chief: Srinivas NAMMI
Open Access
Journal Browser
American Journal of Pharmacological Sciences. 2018, 6(1), 1-6
DOI: 10.12691/ajps-6-1-1
Open AccessArticle

Formulation and Characterization of Fast Dissolving Tablet of Salbutamol Sulphate

Meenakshi Bharkatiya1, , Santosh Kitawat2 and Kalpesh Gaur2

1B. N. Institute of Pharmaceutical Sciences, Udaipur-313001, Rajasthan, India

2Geetanjali Institute of Pharmacy, Geetanjali University, Udaipur-313002, Rajasthan, India

Pub. Date: February 24, 2018

Cite this paper:
Meenakshi Bharkatiya, Santosh Kitawat and Kalpesh Gaur. Formulation and Characterization of Fast Dissolving Tablet of Salbutamol Sulphate. American Journal of Pharmacological Sciences. 2018; 6(1):1-6. doi: 10.12691/ajps-6-1-1


There is an increasing demand for more patient compliant dosage form and a novel method is the development of orally disintegrating tablets which dissolve or disintegrates instantly on the patient tongue or buccal mucosa. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect and make it more cost effective. Oral route having the highest patient compliance is regarded as the most convenient, safest and also the most economical method of drug delivery. Fast dissolving tablets are one such most advantageous example of the oral drug delivery. These tablets readily dissolve or disintegrate in the saliva i.e. within less than 60sec without the need for water. In the present study fast dissolving tablet of Salbutamol Sulphate was formulated, prepared and evaluated. The objective was to fabricate the fast dissolving tablet for rapid release of drug, their characterization, and in-vitro drug release studies. Salbutamol Sulphate being a water soluble drug would be readily available in a dissolved form for rapid oral uptake. The rapid dissolving concept in case of Salbutamol Sulphate could be of a great importance in reliving acute asthmatic shocks. The drug was analyzed by UV, IR and DSC studies. The drug sample was found to comply with all the specifications. The tablets were formulated by using different super disintegrants, in different ratio by various techniques like direct compression, sublimation and solid dispersion. The blends were evaluated for mass volume relationship, flow properties and for compressibility properties. The tablets were evaluated for various physicochemical characteristics like color, odor, thickness, diameter, visual inspection for any defects, weight variation, hardness, friability, disintegration time and wetting time. The tablets were also evaluated for uniformity of drugs content and in-vitro drug release. In conclusion, the tablets prepared by solid dispersion method with crospovidone as a superdisintegrant shows better release profile as compared to other techniques.

orally disintegrating tablets Salbutamol acute asthmatic shocks superdisintegrant

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Bradoo R, Shahani S, Poojary S, Deewan B, Sudarshan S. Fast Dissolving Drug Delivery Systems. JAMA 2001; 4: 27-31.
[2]  Dobetti L. Fast-Melting Tablets: Development and Technologies. Pharm Tech 2001; 37: 44-50.
[3]  Lorenzp Lamosa ML, Cuna M, Vila-Jato JL, Torres D. Fast Dissolving Drug Delivery Systems: An Update. J Microencapsul 1997; 14: 607.
[4]  Chang RK, Guo X, Burnside BA, Couch RA. Fast-dissolving Tablets. Pharm Tech 2000; 24: 52-58.
[5]  Caraballo I, Fernandez-Arevalo M, Millan M. Superdisintegrants in Tablet Formulations. Drug Dev Ind Pharm 1997; 23: 665-669.
[6]  Nayak AK, Manna K. Current developments in orally disintegrating tablet technology. Journal of Pharmaceutical Education and Research 2011; 2(1): 21-34.
[7]  Sreenivas SA, Dandagi PM, Gadad AP, Orodispersible tablet: new drug delivery system-a review. Indian Journal of Pharmaceutical Education and Research 2005; 39(4): 177-181.
[8]  Bhowmik D, Chiranjib B, Pankaj K, Chandira MR, Fast dissolving tablet: an overview. Journal of Chemical and Pharmaceutical Research 2009; 1(1): 163-177.
[9]  Prajapati BG, Ratnakar N. A review on recent patents on fast dissolving drug delivery system. International Journal of PharmTech Research 2009; 1(3): 790-798.
[10]  Chandira MR, Bhowmik DC, Gosh NS, Sahu SR. Studies on resent aspect of mouth dissolving tablet- an overview. Life science 2009; 1:1-19.
[11]  Liberman H.A, Lachman L. In Pharmaceutical Dosage Form: Tablets, 2, Marcell Dekker, Inc, New York.1991; 123: 209-215.
[12]  Sunada H, Yonezawa Y, Danjo K. Studies on evaluation of rapidly disintegrating tablets prepared by direct compression method. Drug Dev Ind Pharm 1999; 25: 571-581.