Antipyretic and Antianemic Activities of Three Anti-malaria Recipes from South Benin on Wistar Rats

Seindé Espérance MEDOATINSA^{1, 2}, Cokou Pascal AGBANGNAN DOSSA^1, , Sossa Pascal ATCHADE³, Gbèdossou Sophie Reine BOGNINOU¹, Kossivi DOSSEH⁴, Tchazou KPATCHA⁴, Amegnona AGBONON⁴, Hyacinthe AHISSOU² and Dominique SOHOUNHLOUE¹

¹Laboratoire d’Etude et de Recherche en Chimie Appliquée (LERCA), Ecole Polytechnique d'Abomey-Calavi (EPAC), Université d'Abomey-Calavi (UAC), 01 BP 2009 Cotonou, Bénin

²Laboratoire d’Enzymologie et de Biochimie des Protéines (LEBP), Faculté des Sciences et Techniques (FAST), Université d’Abomey-Calavi (UAC), Bénin

³Département de Génie de Biologie Humaine (GBH), Ecole Polytechnique d'Abomey-Calavi (EPAC), Université d'Abomey-Calavi (UAC), 01 BP 2009 Cotonou, Bénin

⁴Laboratoire de Physiologie et de Pharmacologie (LPP), Faculté des Sciences (FDS), Université de Lomé (UL), Togo

Cite this paper:
Seindé Espérance MEDOATINSA, Cokou Pascal AGBANGNAN DOSSA, Sossa Pascal ATCHADE, Gbèdossou Sophie Reine BOGNINOU, Kossivi DOSSEH, Tchazou KPATCHA, Amegnona AGBONON, Hyacinthe AHISSOU and Dominique SOHOUNHLOUE. Antipyretic and Antianemic Activities of Three Anti-malaria Recipes from South Benin on Wistar Rats. American Journal of Pharmacological Sciences. 2017; 5(3):57-62. doi: 10.12691/ajps-5-3-1

Abstract

The present study aims to evaluate "in vivo" the acute toxicity, antipyretic and antianemic activities of three plant recipes used in the treatment of malaria in southern Benin lake cities on Wistar rats. We note the presence of saponosides, phenolic compounds, sterols and terpenes in the recipes studied. The toxicity evaluation of the extracts revealed that they are practically non-toxic (LD₅₀> 5g/kg body weight) according to the Hodge and Sterner classification. All the extracts investigated contain antipyretic molecules but only two extracts (aqueous extract obtain by decoction of the child's recipe: 36.07 ± 0.48°C, hydroethanolic macerated of the adult’s recipe: 36.07 ± 0.33°C) showed significant antipyretic activity, similar to that of aspirin (36.03 ± 0.25°C) used as reference molecule in the present study. After evaluating the antianemic activity, we note that the extracts are not hemolytic.

Keywords:
toxicity antipyretic antianemic metabolites plants malaria

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