American Journal of Pharmacological Sciences
ISSN (Print): 2327-6711 ISSN (Online): 2327-672X Website: http://www.sciepub.com/journal/ajps Editor-in-chief: Srinivas NAMMI
Open Access
Journal Browser
Go
American Journal of Pharmacological Sciences. 2016, 4(2), 15-19
DOI: 10.12691/ajps-4-2-1
Open AccessArticle

Antiimplantation and Antiestrogenic Activity of Boerhaavia Diffusa Root Extract in Female Albino Rats

Neetesh Kumar Jain1, , Suman Jain1, S C Mehta2 and S.D. Tonpay2

1School of Studies (SOS) in Pharmaceutical Sciences, Jiwaji University, Gwalior (M.P.), India

2Department of Pharmacology, G R Medical College, Gwalior (M.P.), India

Pub. Date: February 27, 2016

Cite this paper:
Neetesh Kumar Jain, Suman Jain, S C Mehta and S.D. Tonpay. Antiimplantation and Antiestrogenic Activity of Boerhaavia Diffusa Root Extract in Female Albino Rats. American Journal of Pharmacological Sciences. 2016; 4(2):15-19. doi: 10.12691/ajps-4-2-1

Abstract

Disturbance of the natural steroid hormone balance can successfully disorganize the co-ordinate events involved in ovulation, ovum transport and implantation. Thus, compounds possessing estrogenic, progestation and anti-estrogenic, anti-progestational or anti-implantation activity may also exhibit anti-fertility activity. The present study was conducted to investigate the antiimplantation and antiestrogenic activity of Boerhaavia diffusa root extract in female rats. Female albino rats were taken and divided into three groups. Group I served as control, group II received methanolic extract at dose of 200 mg/kg body weight and group III received methanolic extract at dose of 400 mg/kg body weight. The root extract of Boerhaavia diffusa evaluated for anti-implantation activity, The methanolic extract at a dose of 200 mg/kg body weight inhibited pregnancy with mean number of implants 5.58 ± 0.34 [P<0.001]. The same extract at a dose of 400mg/kg body weight significantly inhibited pregnancy with mean number of implants 4.47 ± 0.23 [P<0.001]. The oral administration of the Boerhaavia diffusa methanolic root extract (BDME) at dose of 200 mg/kg and 400 mg/kg body weight caused a significant increase in the uterine weight in immature rats when compared to control, [P<0.001]. These results indicate that the methanolic root extract of Boerhaavia diffusa contain bioactive compounds which may cause antiestrogenic activity. We can conclude that the methanolic extract of Boerhaavia diffusa root showed significant antifertility activity by means of potent antiestrogenic and anti-implantation, in a dose-dependent manner.

Keywords:
Boerhaavia diffusa Antiimplantation Antiestrogenic activity Antifertility

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Ifeanyi PO, Ihemdirim CUO, Victor UO and Idorenyin FE. The potentiality of medicinal plants as the source of new contraceptive principles in males. N Am J Med Sci. 2011; 3(6): 255-263.
 
[2]  Ramesh LL, Sharangouda JP and Saraswati BP. Phytochemical and contraceptive property of sida acuta burm fi. Iin. In albio rats. 2009; 1(4):1260-1266.
 
[3]  Mahesh AR, Harish K, Ranganath MK and Devkar RA. Detail Study on Boerhaavia Diffusa Plant for Its Medicinal Importance- A Review. Res. J. Pharmaceutical Sci, 2012; 1(1):28-36.
 
[4]  Shisode KS and Kareppa BM. In-vitro antioxidant activity and phytochemical studies of boerhaavia diffusa linn. roots. IJPSR, 2011; 2(12): 3171-3176.
 
[5]  Kaur M and Goel RK . Anti-convulsant activity of boerhaavia diffusa: plausible role of calcium channel antagonism. Evidence-Based Complementary and Alternative Medicine.2011: 1-7.
 
[6]  Sharrangouda JP and Saraswati BP. Estrogenic activity of petroleum ether extract of seeds of citrus medica on immature albino rats, 2008. International Journal of Green Pharmacy. April-June 2008.
 
[7]  Vishnu NT, Pankaj SK, Vipin VD, Avinash DD. Antifertility activity of ethanolic extract of allium cepa linn in rats. International Journal of PharmTech Research, 2009; 1: 73-78.
 
[8]  Mutreja A, Agarwal M, Kushwaha S, Chauhan A .Effect of Nelumbo nucifera seeds on the reproductive organs of female rats. Iranian Journal of Reproductive Medicine, 2008; 6(1) : 7-11.
 
[9]  Haneia IM, Hasan A. Abdel L, Reda HE, Wessam MA, Mona IS. Effect of methomyl on fertility, embryotoxicity and physiological parameters in female rats. Journal of Applied Pharmaceutical Science, 2013; 3(12): 109-119.
 
[10]  Farnsworth NR, Bingel AS, Cordell GA, Crane FA and Fong HHS. Potential value of plants as sources of new antifertility agents. J. pharm. Sci, 1975; 64: 535-598.
 
[11]  Sharma RK, Chopra G, Bhushan G and Munjal K. Use of Indian plants in fertility regulation in mammals. J. Exp. Zool, 2003; 6: 57-74.
 
[12]  Psychoyos A. “Recent research on egg implantation”, CIBA foundation study groups, 1966; 2.
 
[13]  Neef G, Beier S, Elger W, Henderson D and Wiechert R. New streoids with antiprogesterone and antiglucocortiocoid activities, Streoids, 1984; 44:349-355.
 
[14]  Sharanabasappa A, Vijaykumar B and Patil SB, Effect of Momordica charantia seed extracts on ovarian and uterine activities in albino rats, Pharm. Biol, 2002; 40:501-506.
 
[15]  Vijaykumar BM, Sharanabasappa A and Saraswati BP, Post-coital antiimplantation and pregnancy interuption potency of the seeds of Crotalaria juncea Linn. Ori. Pharm. Exp. Med, 2004; 4: 70-76.
 
[16]  Pincus G., “Control of Fertility”, Academic Press, New York. 1965; 240.
 
[17]  Saini VK, Plants in the Welfare of Tribal Women and Children in Certain Areas of Central India, Ethnobiology in Human Welfare. Deep Publications, Delhi. 1996; 140-144.