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American Journal of Pharmacological Sciences. 2015, 3(5), 110-119
DOI: 10.12691/ajps-3-5-2
Open AccessResearch Article

Nasal Drug Delivery Systems: An Overview

Muhammad U. Ghori1, Mohammed H. Mahdi1, Alan M. Smith1 and Barbara R. Conway1,

1Department of Pharmacy, University of Huddersfield, Huddersfield, UK

Pub. Date: December 18, 2015
(This article belongs to the Special Issue Recent Advances in Controlled Drug Delivery Systems)

Cite this paper:
Muhammad U. Ghori, Mohammed H. Mahdi, Alan M. Smith and Barbara R. Conway. Nasal Drug Delivery Systems: An Overview. American Journal of Pharmacological Sciences. 2015; 3(5):110-119. doi: 10.12691/ajps-3-5-2


Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades. Intra-nasal administration of drugs offers an interesting alternative for achieving systemic therapeutic effects of drugs that are comparable to the parenteral route, which can be inconvenient at times or oral administration, which can result in unacceptably low drug bioavailability. So, it is important to understand the potential and limitations of various nasal drug delivery systems. Therefore, the aim of this review article is to discuss the various pharmaceutical dosage forms that have the potential to be utilised for local or systemic drug administration. It is intuitively expected that this review will help to understand and further to develop suitable intra-nasal formulations to achieve specific therapeutic objectives.

nose intra-nasal bioavailability mucoadhesion drug delivery systems

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