American Journal of Pharmacological Sciences
ISSN (Print): 2327-6711 ISSN (Online): 2327-672X Website: http://www.sciepub.com/journal/ajps Editor-in-chief: Srinivas NAMMI
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American Journal of Pharmacological Sciences. 2015, 3(3), 55-66
DOI: 10.12691/ajps-3-3-2
Open AccessReview Article

Plants Explored with Anti-diabetic Properties: A Review

Om Prakash1, Rajesh Kumar1, Ritika Srivastava1, Pragya Tripathi1, Shradha Mishra2 and Ajeet3,

1Faculty of Pharmacy, Kamla Nehru Institute of Management & Technology, Sultanpur, Uttar Pradesh

2Faculty of Pharmacy, Sagar Institute of Technology & Management, Barabanki, Uttar Pradesh

3S. D. College of Pharmacy and Vocational Studies, Muzafffarnagar, Uttar Pradesh, India

Pub. Date: May 24, 2015

Cite this paper:
Om Prakash, Rajesh Kumar, Ritika Srivastava, Pragya Tripathi, Shradha Mishra and Ajeet. Plants Explored with Anti-diabetic Properties: A Review. American Journal of Pharmacological Sciences. 2015; 3(3):55-66. doi: 10.12691/ajps-3-3-2

Abstract

Diabetes mellitus is a chronic heterogeneous disorder; affecting the β-cells of endocrinal pancreatic gland, globally the numbers of cases of diabetes is increasing gradually. There are several medicines available in the market to treat diabetes mellitus but no drug is found to be fully effective and safe. However plants and plant-derived products have proven to be effective and safe in the treatment of various types of diabetes mellitus. In Indian system of medicine, several medicinal plants have found potential use as blood sugar lowering agents. Many of them have been scientifically explored for their usefulness in managing diabetes, the reports of which have been acknowledged and published in a number of scientific journals. At present most research work on diabetic drugs is targeted on plants and plants-derived products. Many natural products and their analogues have been identified as potent anti-diabetic agents. Here, an attempt is being made through this article to provide an in-depth and comprehensive review on various plant species that have been explored as anti-diabetic agents.

Keywords:
diabetes mellitus insulin natural products glucose

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References:

[1]  Barcelo A, Rajpathak S. “Incidence and prevalence of diabetes mellitus in the Americas”. American Journal of Public Health, 10, 300-308, 2001.
 
[2]  Pari L, Saravanan R. “Antidiabetic effect of diasulin, an herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose metabolism in hyperglycaemic rats”. Diabetes, Obesity and Metabolism, 6, 286-292. 2004.
 
[3]  Worthley LIG. The Australian short course on intensive care medicine, Handbook, Gillingham Printers, South Australia; 2003, 31-55.
 
[4]  Conn EE. & Stumph PK. Outline of Biochemistry, 5th Edition, John Wiley & sons, New York.
 
[5]  Holt RIG. “Diagnosis, epidemiology and pathogenesis of diabetes mellitus: an update for psychiatrists”. British Journal of Psychiatry. 184, s55-s63, 2004.
 
[6]  Tiwari AK, Rao JM. “Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects”. Current Science. 83, 30-38, 2002.
 
[7]  National Diabetes Fact Sheet (NDFS), United States (2005). (http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2005.pdf) (Accessed on November 10, 2009).
 
[8]  Abebe D, Debella A, Urga K. Illustrative checklist: Medicinal plants and other useful plants of Ethiopia. EHNRI, Nairobi, Kenya: Camerapix Publisher International. 188-194, 2003.
 
[9]  Cavallerano JOD, Cooppan R. Optometric clinical practice guideline care of the patient with diabetes mellitus. American Optometric Association 243 N. Lindbergh Blvd., St. Louis, MO 63141-7881, 3rd ed., U.S.A, 2002.
 
[10]  Trachtenbarg DE. “Diabetic ketoacidosis”. American Family Physician, 2005; 71: 1705-1714.
 
[11]  Ostenson CG. “The pathophysiology of type 2 diabetes mellitus: an overview”. Acta Physiology of Scandinavian, 171, 241-247, 2001.
 
[12]  Lindstrom J, Eriksson JG, Valle TT, Aunola S, Cepaitis Z, Hakumaki M et al. “Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the Finnish diabetes prevention study: Results from a randomized clinical trial”. Journal of the American Society of Nephrology, 14, S108-S113, 2003.
 
[13]  Uusitupa M. “Lifestyles matter in the prevention of Type 2 diabetes”. Diabetes Care, 25, 1650-1651, 2002.
 
[14]  Li WL, Zheng HC, Bukuru J, Kimpe ND. “Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus”. Journal of Ethnopharmacology, 92, 1-21, 2004.
 
[15]  Kamalakkanan N, Prince PSM. “Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin-diabetic rats”. Journal of Ethnopharmacology, 87, 207-210, 2003.
 
[16]  Sobngwi E, Mauvais F, Vexiau P, Mbanya JC, Gautier JF. “Diabetes in Africans Part 1: epidemiology and clinical specificities”. Diabetes Metabolism (Paris), 27, 628-634, 2001.
 
[17]  Andrade A, Heinrich M. “Mexican plants with hypoglycemic effect used in the treatment of diabetes”. Journal of Ethnopharmacology, 99, 325-348, 2005.
 
[18]  Attele AS, Zhou Y, Xie J, Wu JA, Zhang L, Dey L et al. “Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component”. Diabetes, 51, 1851-1858, 2002.
 
[19]  Ramachandran A, Snehalatha C, Viswanathan V. “Burden of type 2 diabetes and its complications –The Indian scenario”. Current Science, 83, 1471-1476, 2002.
 
[20]  Wild S, Roglic G, Green A, Sicree R, King H. “Global prevalence of diabetes estimates for the year 2000 and projections for 2030”. Diabetes Care, 27, 1047-1053, 2004.
 
[21]  Alberti KGM, Zimmet P, Shaw J. “International Diabetes Federation: a consensus on Type 2 diabetes prevention”. Diabetic Medicine, 24, 451-463, 2007.
 
[22]  Libman IM, Arslanian SA. “Prevention and treatment of Type 2 diabetes in youth”. Hormone Research, 67, 22-34, 2007.
 
[23]  Colagiuri RN, Colagiuri S, Yach D, Pramming S. “The answer to diabetes prevention: Science, surgery, service delivery, or social policy?” American Journal of Public Health, 96, 1562-1569, 2006.
 
[24]  Ignacimuthu S, Ayyanar M, Sivaraman SK. “Ethnobotanical investigations among tribes in Madurai district of Tamil Nadu (India)”. Journal of Ethnobiology and Ethnomedicine, 2, 1-7, 2006.
 
[25]  Elujoba AA, Odeleye OM, Ogunyemi CM. “Traditional medicine development for medical and dental primary health care delivery system in Africa”. African Journal of Traditional, Complementary and Alternative Medicine, 2, 46-61, 2005.
 
[26]  Tomlinson TR, Akerele O. “Medicinal plants: their role in health and biodiversity”. University of Pennsylvania Press, Philadelphia, 11-41, 1998.
 
[27]  Kochhar A, Nagi M. “Effect of supplementation of traditional medicinal plants on blood glucose in non–insulin-dependent diabetics: A Pilot Study”. Journal of Medicinal Food,; 8: 545-549.
 
[28]  Zibula SMX, Ojewole JAO. “Hypoglycemic effects of Hypoxis hemerocallidea corm ‘African potato' methanolic extract in rats”. Medical Journal of Islamic Academy of Sciences, 13, 75-78, 2000.
 
[29]  Ribnicky DM, Poulev A, Watford M, Cefalu WT, Raskin I. “Antihyperglycemic activity of Tarralin, an ethanolic extract of Artemisia dracunculus L.” Phytomedicine,, 13, 550-557, 2006.
 
[30]  Eshrat HMA. “Hypoglycemic, hypolipidemic and antioxidant properties of combination of curcumin from Curcuma longa, linn, and partially purified product from Abroma augusta Linn. In streptozotocin induced diabetes”. Indian Journal of Clinical Biochemistry, 17, 33-43, 2002.
 
[31]  Oubre AY, Carlson TJ, King SR, Reaven GM. “From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM”. Diabetologia, 40, 614-617, 1997.
 
[32]  Wadood A, Wadood N, Shah SA. “Effects of Acacia arabica and Carallum edulis on blood sugar levels of normal and alloxan diabetic rabbits”. Journal of Pakistan Medical Association, 39(8), 208-212, 1989.
 
[33]  Tanko Y, Yerima M, Mahdi MA, Yaro AH, Musa KY, Mohammed A. “Hypoglycemic Activity of Methanolic Stem Bark of Adansonnia digitata Extract on Blood Glucose Levels of Streptozocin-Induced Diabetic Wistar Rats”. International Journal of Applied Research in Natural Products, 1(2), 32-36, 2008.
 
[34]  Hong Gao, Yi-Na Huang, Bo Gao, Peng Li, Chika Inagaki and Jun Kawabata. “Inhibitory effect on α-glucosidase by Adhatoda vasica Nees. Food Chemistry, 108(3), 965-972, 2000.
 
[35]  Sabu MC, Ramadasan K. “Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties”. Indian J Physiol Pharmacol, 48(1), 81-88, 2001.
 
[36]  Awadi FMA, Gumaa KA. “Study on the activity of the individual plants of an antidiabetic mixture”. Acta Diabetologica Latina, 24, 37-41, 1987.
 
[37]  Ajabnoor MA. “Effect of aloes on blood glucose level in normal and alloxan diabetic mice”. Journal of Ethnopharmacology, 8, 215-220, 1990.
 
[38]  Nalamolu Koteswara Rao. “Anti-Hyperglycemic and renal protective activities of Andrographis paniculata roots chloroform Extract”. Iranian Journal of Pharmacology & Therapeutics, 5, 47-50, 2006.
 
[39]  Kumar V, Khanna AK, Khan MM, Singh R, Singh S, Chander R et al. “Hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus in alloxan induced diabetic rats”. Indian Journal of Clinical Biochemistry, 24(1), 65-69, 2009.
 
[40]  Selvan VT, Manikandan L, Kumar GPS, Suresh R, Kakoti BB, Gomathi P et al. “Antidiabetic and antioxidant effect of methanol extract of Artanema sesamoides in Streptozotocin-induced Diabetic rats”. International Journal of Applied Research in Natural Products, 1(1), 25-33, 2008.
 
[41]  Chattopadhyay RR, Chattopadhyay RN, Nandy AK, Poddar G, Maitra SK. “The effect of fresh leaves of Azadirachta indica on glucose uptake and glycogen content in the isolated rat hemi diaphragm”. Bulletin of the Calcutta School of Tropical Medicine, 35, 8-12, 1987.
 
[42]  Pari L, Satheesh MA. “Antidiabetic activity of Boerhaavia diffusa L. effect on hepatic key enzymes in experimental diabetes”. Journal of Ethnopharmacology, 91(1), 109-113, 2004.
 
[43]  Deore SL, Khadabadi SS, Daulatkar VD, Deokate UA, Farooqui IU. “Evaluation of hypoglycemic and antidiabetic activity of bark of Butea monosperma. Phcog Mag, 4(13), 134-138, 2008.
 
[44]  Parameshwar S, Srinivasan KK, Rao CM. “Oral Antidiabetic Activities of Different Extracts of Caesalpinia bonducella Seed Kernels”. Pharmaceutical Biology, 40(8), 590-595, 2002.
 
[45]  Hakkim FL, Girija S, Kumar RS, Jalaludeen MD. “Effect of aqueous and ethanol extracts of Cassia auriculata L. flowers on diabetes using alloxan induced diabetic rats”. International Journal of Diabetes & Metabolism, 15, 100-106, 2007.
 
[46]  Pari L, Latha M. “Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats”. Singapore Med J, 43(12), 617-621, 2002.
 
[47]  Kamble SM, Kamlakar PL, Vaidya S, Bambole VD. “Influence of Coccinia indica on certain enzymes in glycolytic and lipolytic pathway in human.” Indian Journal of Medical Science, 52(4), 143-146, 1998.
 
[48]  Singh N, Singh SP, Vrat S, Mishra N, Dixit KS, Kohli RP. “A study n the antidiabetic activity of Coccinia indica in dogs”. Indian Journal of Medical Science, 39(2), 27-29, 1985.
 
[49]  Ravi K, Sivagnanam K, Subramanian S. “Antihyperlipidemic effect of Eugenia jambolana seeds kernels on streptozotocin induced diabetes in rats”. Journal of Medicinal Food, 72(2), 187-191, 2004.
 
[50]  Sharma S, Chaturvedi M, Edwin E, Shukla S, Sagrawat H. “Evaluation of the phytochemicals and antidiabetic activity of Ficus bengalensis. International Journal of Diabetes, 27(2), 56-59, 2007.
 
[51]  Rao RB, Murugesan T, Sinha S, Saha BP, Pal M, Mandal SC. “Glucose lowering efficacy of Ficus racemosa bark extract in normal and alloxan diabetic rats”. Phytotherapy Research, 16(6), 590-592, 2002.
 
[52]  Shanmugasundaram ER, Panneerselvam C, Samudaram P, Shanmugasundaram KR. “Enzyme changes and glucose utilization in diabetic rats”. Journal of Ethnopharmacology, 7(2), 205-234, 1983.
 
[53]  Mahalingam G, Krishnan K. “Hypoglycemic activity of Hemidesmus indicus R. Br. on streptozotocin-induced diabetic rats”. International Journal of Diabetes, 28(1), 6-10, 2008.
 
[54]  Venkatesh S, Thilagavathi J, Shyam Sundar D. “Anti-diabetic activity of flowers of Hibiscus rosasinensis, Fitoterapia, 79(2), 79-81, 2008.
 
[55]  Pankaj NK, Alam M, Roy BK, “Antidiabetic activity of seed powder of Holarrhena antidysenterica in rabbits”. Journal of Research, Birsa Agricultural University, 2006.
 
[56]  Syamsudin, Inawati, Winarno H. “The effect of inai (Lawsonia inermis) leaves extract on blood glucose level: an experimental study”. Research Journal of Pharmacology, 2(2), 20-23, 2008.
 
[57]  Eddouks M, Maghrani M, Zeggwagh NA, Michel JB. “Study of the hypoglycaemic activity of Lepidium sativum L. aqueous extract in normal and diabetic rats”. Journal of Ethnopharmacology, 97, 391-395, 2008.
 
[58]  Cakici I, Hurmoglu C, Tunctan AB, Kanzik NI, Sener B. “Hypoglycemic effects of Momordica charantia extract in normoglycaemic or cyproheptadin induced hyperglycaemic mice”. Journal of Ethnopharmacology, 44(2), 117-122, 1994.
 
[59]  Somani RS, Singhai AK. “Hypoglycaemic and antidiabetic activities of seeds of Myristica fragrans in normoglycaemic and alloxan-induced diabetic rats”. Asian J. Exp. Sci, 22(1), 95-102, 2008.
 
[60]  Hannan JMA, Marenah L, Ali L, Rokeya B, Flatt PR, Wahab YHA. “Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic ß-cells”. Journal of Endocrinology, 189, 127-136, 2006.
 
[61]  Augusti KT. “Studies on the effects of a hypoglycaemic principle from Allium cepa. Indian J. of Medicinal Research, 6(7), 1066-1071, 1973.
 
[62]  Jasmin HB, Narasimhacharya AVRL. “Comparative antidiabetic, hypolipidemic, and antioxidant properties of Phyllanthus niruri in normal and diabetic rats”. Pharmaceutical Biology, 45(7), 569-574, 2007.
 
[63]  Indian Council of Medical Research (I.C.M.R), Collaborating Centres. Flexible dose open trial of Vijayasar in cases of newly diagnosed non-insulin dependent diabetes mellitus, New Delhi. Indian Journal of Medical Research, 108, 24-29, 1998.
 
[64]  Nilambari D, Shrikant T, Vipinchandra PA. “Comprehensive Review of Rubia cordifolia Linn.” Pharmacognosy Reviews, 2(3), 124-134, 2008.
 
[65]  Kumar GPS, Arunselvan P, Kumar DS, Subramanian SP. “Anti-diabetic activity of fruits of Terminalia chebula on streptozotocin-induced diabetic rats”. Journal of Health Science, 52(3), 283-291, 2006.
 
[66]  Stanely P, Prince M, Menon VP. “Hypoglycemic and other related action of Tinospora cordifolia roots in alloxan induced diabetic rats”. Journal of Ethnopharmacology, 70(1), 9-15, 2000.
 
[67]  Grover JK, Vats V, Rathi SS. “Antihyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzyme involved in carbohydrate metabolism”. Journal of Ethnopharmacology, 73(3), 461-470, 2000.
 
[68]  Zia T, Hasan SN, Hasan SK. “Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice”. Journal of Ethnopharmacology, 75(2-3), 191-195, 2001.
 
[69]  Kumar RU, Kasturirenghan S, Mariashibu TS, Manoharan R, Vasudevan RA, Sei CK et al. “Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on Alloxan-induced diabetic rats”. Int. J. Mol. Sci, 10, 2367-2382, 2009.
 
[70]  Li WL, Zheng HC, Bukuru J, Kimpe ND. “Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus”. Journal of Ethnopharmacology, 92, 1-21, 2004.
 
[71]  Kokate C K, Purohit JP, Gokhale SB. Pharmacognosy. 31st edition Nirali Prakashan; Pune, 133-599, 2005.