American Journal of Pharmacological Sciences
ISSN (Print): 2327-6711 ISSN (Online): 2327-672X Website: http://www.sciepub.com/journal/ajps Editor-in-chief: Srinivas NAMMI
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American Journal of Pharmacological Sciences. 2015, 3(2), 49-51
DOI: 10.12691/ajps-3-2-4
Open AccessArticle

Antioxidant Effects of Picrorhiza kurrooa Rhizome Extracts in Alcoholic Cirrhosis of Liver

Neelesh Deshpande1, Raj kumar Das1, Manohar muddeshwar1, Vaishali Das1, Sabitha Kandi2 and K V Ramana3,

1Department of Biochemistry, Government Medical College and Superspeciality hospital, Nagpur, India

2Department of Biochemistry, Chalmeda Anandarao Institute of Medical Sciences, Karimnagar, India

3Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India

Pub. Date: May 08, 2015

Cite this paper:
Neelesh Deshpande, Raj kumar Das, Manohar muddeshwar, Vaishali Das, Sabitha Kandi and K V Ramana. Antioxidant Effects of Picrorhiza kurrooa Rhizome Extracts in Alcoholic Cirrhosis of Liver. American Journal of Pharmacological Sciences. 2015; 3(2):49-51. doi: 10.12691/ajps-3-2-4

Abstract

Picrorhiza kurrooa is mentioned in Ayurveda for the treatment of many disorders, but it has not been subjected to systematic scientific investigations to assess its antioxidant activity and hepatoprotective properties in alcoholic cirrhosis of liver. The methanol extracts of P. kurrooa Rhizomes significantly reduced oxidative stress and elevated antioxidants which were measured spectrophotometrically. The results of the study revealed that there was significant reduction in the activities of liver enzymes among the liver cirrhosis patients after the treatment with the P Kurrooa plant extract. The post-treatment results also showed significant correlation in the activities of malondialdehyde, glutathione peroxidase and superoxide dismutase in the liver of alcoholic patients.

Keywords:
Picrorhiza kurrooa antioxidant activity alcoholic cirrhosis of liver

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