American Journal of Pharmacological Sciences
ISSN (Print): 2327-6711 ISSN (Online): 2327-672X Website: http://www.sciepub.com/journal/ajps Editor-in-chief: Srinivas NAMMI
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American Journal of Pharmacological Sciences. 2014, 2(2), 32-36
DOI: 10.12691/ajps-2-2-1
Open AccessArticle

In Vitro Dissolution Pattern of Metronidazole Film Coated Tablet in Presence of Fruit Juice

Faisal Asif1, Tania Sultana1, Md. Didaruzzaman Sohel1, , Md. Helal Uddin Sumon2, Md. Hassan Kawsar1 and Md. Ashraful Islam1

1Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh

2Department of Pharmacy, University of Development Alternative, Dhaka, Bangladesh

Pub. Date: February 20, 2014

Cite this paper:
Faisal Asif, Tania Sultana, Md. Didaruzzaman Sohel, Md. Helal Uddin Sumon, Md. Hassan Kawsar and Md. Ashraful Islam. In Vitro Dissolution Pattern of Metronidazole Film Coated Tablet in Presence of Fruit Juice. American Journal of Pharmacological Sciences. 2014; 2(2):32-36. doi: 10.12691/ajps-2-2-1

Abstract

This study concentrates on dissolution of drug in presence of fruit juice specifically mango juice. This work aspires current research to study the dissolution approach pattern of commercial formulation of metronidazole in Bangladesh commercially available eight brands of metronidazole film coated tablets were studied in gastric medium (pH 1.2). All brands got reasonably higher dissolution release mainly M02 (84.79%), M05 (75.86%), M06 (72.53%) and M07 (86.48%) were released relatively faster than other sample in 15 to 50 minutes. Therefore, Mango juice assists to enhance the therapeutic response of metronidazole on set of quick response.

Keywords:
dissolution study gastric medium mango juice metronidazole release

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