American Journal of Pharmacological Sciences
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American Journal of Pharmacological Sciences. 2014, 2(1), 12-17
DOI: 10.12691/ajps-2-1-3
Open AccessArticle

Hemodynamic Effects of Local Anesthesia and its Possible Correlation with Chromogranin A

Maha T. Al–Saffar1, Tahani A. AL-Sandook2 and Mahmoud Y. Taha1,

1Department of Dental Basic Science, College of Dentistry, Mosul University, Mosul, Iraq

2Iraq Cultural Attachi, Washington, USA

Pub. Date: January 22, 2014

Cite this paper:
Maha T. Al–Saffar, Tahani A. AL-Sandook and Mahmoud Y. Taha. Hemodynamic Effects of Local Anesthesia and its Possible Correlation with Chromogranin A. American Journal of Pharmacological Sciences. 2014; 2(1):12-17. doi: 10.12691/ajps-2-1-3


Aim: To study the effects of local anesthesia on blood pressure in patients undergo extraction of maxillary teeth under infiltration local anesthesia and to compare the level of salivary chromogranin A before and after administration of local anesthesia and its possible correlation with hemodynamic effects of local anesthesia. Materials and Methods: A total of 26 patients (18 female, 8 male) who need tooth extraction under infiltration local anesthesia were examined in two situations (pre and post local anesthetic administration). For each patient salivary sample was collected by salivette to estimate the level of chromogranin A using ELISA Kits. For all patients, the blood pressure and pulse rate were measured before and after administration of local anesthesia using automatic blood pressure recorder. Results: the results showed significant differences between salivary chromogranin A for patients before the administration of local anesthesia (580.33 ± 130.42) ng/ml and after the administration of local anesthesia (674.51+ 130.93) ng/ml with p < 0.05. The results also showed that the mean value of blood pressure (systolic and diastolic blood pressure) lowered after administration of local anesthesia but with no significant differences (p > 0.05) with pre –local anesthetic value. The pulse rate was increase in it is value after local anesthetic administration with a significant differences (p < 0.05) than pre – anesthetic value. Conclusions: tooth extraction and administration of infiltration local anesthesia caused hypotension with no significant effect (p > 0.05) while it caused increase in pulse rate with a significant effect (p < 0.05). Administration of infiltration local anesthesia caused significant effects on salivary chromogranin A levels, also this study showed that there was significant inverse correlation between systolic blood pressure and chromogranin A levels(p < 0.05) after administration of infiltrations local anesthesia during dental treatments (tooth extraction).

salivary chromogranin A local anesthesia blood pressure

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