American Journal of Pharmacological Sciences
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American Journal of Pharmacological Sciences. 2014, 2(1), 7-11
DOI: 10.12691/ajps-2-1-2
Open AccessArticle

Anti-Inflammatory Activity of Silibinin in Animal Models of Chronic Inflammation

Tavga Ahmed Aziz1, Bushra Hasan Marouf1, Zheen Aorahman Ahmed2 and Saad Abdulrahman Hussain3,

1Department of Pharmacology and Toxicology, School of Pharmacy, Faculty of Medical Sciences, University of Sulaimani, Kurdistan, Iraq

2Department of Pharmacology, School of Medicine, Faculty of Medical Sciences, University of Sulaimani, Kurdistan, Iraq

3Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq

Pub. Date: January 16, 2014

Cite this paper:
Tavga Ahmed Aziz, Bushra Hasan Marouf, Zheen Aorahman Ahmed and Saad Abdulrahman Hussain. Anti-Inflammatory Activity of Silibinin in Animal Models of Chronic Inflammation. American Journal of Pharmacological Sciences. 2014; 2(1):7-11. doi: 10.12691/ajps-2-1-2


Attenuation of the chronic inflammatory response is a beneficial strategy to combat several human diseases. Traditional medicine offers many plant extracts and pure natural compounds as treatment options of a wide variety of disorders including acute and chronic inflammation. The present study was designed to evaluate the anti-inflammatory effect of silibinin in experimental animal models of chronic and granulomatous inflammations. Forty-eight rats were used to induce chronic inflammation in the hind paw with formalin and granulomatous inflammation with sterile cotton pellets. The anti-inflammatory activity of silibinin (300 mg/kg, P.O) was evaluated in the two models, and compared with that produced by dexamethasone (1 mg/kg, P.O). Silibinin decreased significantly the formation of exudate and granulation tissue compared with the vehicle, but still significantly lower than that produced by dexamethasone. In conclusion, our data suggest that silibinin inhibits the production of edema and granulation tissue in experimental animal models of chronic inflammation, and could be a potential choice for the treatment of chronic inflammatory disorders.

silibinin chronic inflammation granuloma rats

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