American Journal of Pharmacological Sciences
ISSN (Print): 2327-6711 ISSN (Online): 2327-672X Website: http://www.sciepub.com/journal/ajps Editor-in-chief: Srinivas NAMMI
Open Access
Journal Browser
Go
American Journal of Pharmacological Sciences. 2021, 9(1), 36-39
DOI: 10.12691/ajps-9-1-3
Open AccessArticle

Phytochemical Profile and Potential Pharmacological Properties of Leaves Extract of Senna italica Mill

Euloge Sènan Adjou1, Alain Yaya Koudoro1, Guevara Nonviho1, Edwige Dahouenon Ahoussi1 and Dominique C. K. Sohounhloue1,

1Laboratory of Study and Research in Applied Chemistry, University of Abomey-Calavi, Polytechnic School of Abomey-Calavi, 01, P. O. Box 2009, Cotonou

Pub. Date: April 01, 2021

Cite this paper:
Euloge Sènan Adjou, Alain Yaya Koudoro, Guevara Nonviho, Edwige Dahouenon Ahoussi and Dominique C. K. Sohounhloue. Phytochemical Profile and Potential Pharmacological Properties of Leaves Extract of Senna italica Mill. American Journal of Pharmacological Sciences. 2021; 9(1):36-39. doi: 10.12691/ajps-9-1-3

Abstract

The leaves of Senna italica Mill., were screened for phytochemical properties using standard methods. Anthocyanins, leucoanthocyanins, catechics tannins, flavonoids, alkaloids, anthraquinones and reducer compounds were detected. However, saponins, coumarines and cyanogenic derivatives were not detected in the leaves extract. Taking into account of presence of these secondary metabolites in the plant extract, it could be suggested that this plant has a potential as a source of therapeutic agents. This supports the traditional use of the plant in curing human diseases. It is therefore suggested that further studies be carried out to isolate, purify and identify all active compounds present in all part of this plant.

Keywords:
Senna italica phytochemistry secondary metabolites pharmacological properties Benin

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Dabai, Y. U., Kawo, A. H., Aliyu, R. M. (2012). Phytochemical screening and antibacterial activity of the leaf and root extracts of Senna italica. African Journal of Pharmacy and Pharmacology, 6(12), 914-918.
 
[2]  Adjou, E.S., Ladekan, E.Y., Koudoro, A.Y., Dahouenon-Ahoussi, E., Sohounhloue, D.C.K. (2020). Phytochemical profile and associated microflora of Morinda citrifolia L. (Rubiaceae) juice used as source of traditional nutraceuticals. Journal of Pharmacognosy and Phytochemistry, 9(4), 776-779.
 
[3]  Kawo, A.H., Suleiman, Z.A., Yusha’u, M. (2011). Studies on the antibacterial activity and chemical constituents of Khaya senegalensis and Ximenia americana leaf extracts. Afr. J. Microbiol. Res., 5(26), 4562-4568.
 
[4]  Agbankpe A. J.., et al. “HPLC Standardization of Herbal Drugs and Evaluation of their Antimicrobial Properties: Studies of Leaves and Flowers of Senna italica Mill. Grown in Benin (Western Africa)”. EC Pharmacology and Toxicology 8.2 (2020): 01-17.
 
[5]  World Health Organization (WHO). “Promoting the role of traditional medicine in the health system: Strategy of the African region AFR/RC50/9”. Harare: Africa regional office (2001): 20.
 
[6]  Rahman, A. H. M., Parvin, M. I. A. (2015). Study of medicinal uses of Fabaceae family at Rashayi, Bangladesh. Plant, 3, 20-25.
 
[7]  Khala, O. M., Ghareeb M. A., Saad A. M., Madkour H.M.F., El-Ziaty AK., Abdel-Aziz. M S. (2017). Phenolic Constituents, Antimicrobial, Antioxidant, and Anticancer Activities of Ethyl Acetate and n-Butanol Extracts of Senna italica. Acta Chromatographica 312, 138-145.
 
[8]  Vijaya B.R., Radha R., Micheal R.S., Praveena M., Sasikala S. (2018). A review article on Senna italica Mill. Int. J. Pharm. Sci. Rev. Res., 52(2), 44-46.
 
[9]  Ahangarpour, A., Oroojan, AA. (2010). The effects of Cassia italica leaves aqueous extract on non-pregnant uterus contraction in rats”. Iranian Journal of Reproductive Medicine 8. (4), 179-184.
 
[10]  Sofowora A. (1993). Medicinal plants and Traditional Medicine in Africa. Spectrum Books, Ibadan. pp 150.
 
[11]  Ogbeibu A.E. (2005). Biostatistics, a Practical Approach to Research and Data Handling (Mindex Publishing Company Ltd., Benin City. pp264.
 
[12]  Deba, F., Xuan T.D., Yasuda M., Tawatu, S. (2008). Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. Var. Radiata. Food Control, 19, 346-352.
 
[13]  Liu, A.L., et al., (2009). In vitro anti-influenza viral activities of constituents from Caesalpinia sappan, Planta Med., 75, 337-9.
 
[14]  Okwu, D.E., Josiah, C. (2006). Evaluation of the chemical composition of two Nigerian medicinal plants. Afri. J. Biotech., 5, 357-361.
 
[15]  Ruiz-Cruz S., et al. (2017). Flavonoids: Important Biocompounds in Food, Flavonoids - From Biosynthesis to Human Health, Goncalo C. Justino, IntechOpen.
 
[16]  Malik E.M., Müller CE (2016). Anthraquinones as pharmacological Tools and Drugs. Med Res Rev, 36(4), 705-48.
 
[17]  Susunaga-Notario, A. C (2014) Bioassay-guided chemical study of the antiinflammatory effect of Senna vilosa (Miller) HS irwin Barnely (leguminosae) in TPA-induced ear edema. Molecules, 19 (7), 10261-10278.
 
[18]  Jimenez-Coello, M., Guzmán, E. S., Pérez, M. S., Polanco, G., Acosta, K. (2011). Antitripanosomal Activity of Senna villosa in infected Balb /C mice with Trypanosoma cruzi during the sub-acute phase of infection. Afr. J. Tradit. Complement. Altern. Med, 8, 164-169.
 
[19]  Guzmán, E. S., Pérez, C., Zavala, M. A., Pérez, M. S. (2008). Antiprotozoal activity of 8-hydroxymethylen)-trieicosanylacetate isolate from Senna villosa. Phytomedicine, 15 (10), 892-895.
 
[20]  Mokgotho, M. P., Gololo, S. S., Masoko, P., Mdee, L. K., Mbazima, V., Shai, L.J. (2013). Isolation and chemical structural characterization of the coumpound with antioxidant activity from the roots of Senna italica. Evid. Based Compl. Alt. Med., 1-6.
 
[21]  Masoko, P. A., Gololo, S. S., Mokgotho, M. P., Eloff, J. N., Howard, R. I., Mampuru, L. (2010). Evaluation of the antioxidant, antibacterial and antiproliferative activities of the acetone extract of the root of Senna italica. J. Afr. J. Tradit. Complement. Altern. Med., 7(2), 138-148.