American Journal of Pharmacological Sciences
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American Journal of Pharmacological Sciences. 2013, 1(6), 104-115
DOI: 10.12691/ajps-1-6-1
Open AccessReview Article

Anticancer Potential of Plants and Natural Products: A Review

Om Prakash1, Amit Kumar1, Pawan Kumar1 and Ajeet2,

1Department of Pharmacy, Sagar Institute of Technology & Management, Barabanki, Uttar Pradesh, India

2S. D. College of Pharmacy and Vocational Studies, Muzafffarnagar, Uttar Pradesh, India

Pub. Date: December 24, 2013

Cite this paper:
Om Prakash, Amit Kumar, Pawan Kumar and Ajeet. Anticancer Potential of Plants and Natural Products: A Review. American Journal of Pharmacological Sciences. 2013; 1(6):104-115. doi: 10.12691/ajps-1-6-1

Abstract

Cancer is one of the leading causes of death and globally the numbers of cases of cancer are increasing gradually. There are several medicines available in the market to treat the various types of cancer but no drug is found to be fully effective and safe. The major problem in the cancer chemotherapy is the toxicity of the established drugs. However plants and plant derived products have proved effective and safe in the treatment and management of cancers. These days most of the research work on cancer drugs is targeted on plants and plants derived natural products. Many natural products and their analogues have been identified as potent anti-cancer agents and day by day the anti-cancer property of various plants is being identified. Here an attempt is being made through this review to highlights the natural products and their analogues established as anti-cancer agents and the new plant species identified with anti-cancer properties either in vivo or in vitro.

Keywords:
cancer cells natural products plants carcinoma

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References:

[1]  Krishnamurthi K. Screening of natural products for anticancer and antidiabetic properties. Health Administrator. XX (1&2): 69, (2000).
 
[2]  Charaka. Charaka Samhita. Chaukhamba Publications, Varanasi, India; 700 BC: 215.
 
[3]  Susruta. Susruta Samhita. Chaukhamba Publications, Varanasi, India ; 700 BC: 520.
 
[4]  Misra B. Bhawa Prakash Nighantu. Chaukhamba Publications, Varanasi, India; 1600 AD: 298.
 
[5]  Kapoor L. D. Handbook of ayurvedic medicinal plants. CRC Press, Florida; 1990.
 
[6]  Balachandran P, Govindarajan R., Cancer- an ayurvedic perspective. Pharmacology Research, 51. 19. 2005.
 
[7]  Singh R. H., An assessment of the ayurvedic concept of cancer and a new paradigm of anticancer treatment in Ayurveda. Journal of Alternative & Complementary Medicine, 8. 609. 2002.
 
[8]  Ignacimuthu S, Ayyanar M, Sivaraman S.K., Ethnobotanical investigations among tribes in Madurai district of Tamil Nadu (India). Journal of Ethnobiology and Ethnomedicine, 2. 1. 2006.
 
[9]  Elujoba A. A., Odeleye O. M., Ogunyemi C. M., Traditional medicine development for medical and dental primary health care delivery system in Africa. African Journal of Traditional, Complementary and Alternative Medicines, 2. 46. 2005.
 
[10]  Tomlinson T. R., Akerele O., Medicinal plants: their role in health and biodiversity. University of Pennsylvania Press, Philadelphia, 1998.
 
[11]  Gordon M. C., David J., Plants as a source of anti-cancer agents. Journal of Ethnopharmacology, 100. 72. 2005.
 
[12]  Gueritte F., Fahy J., The vinca alkaloids. In Anticancer Agents from Natural Products, edited by Cragg GM, Kingston DGI, Newman DJ. Brunner-Routledge Psychology Press, Taylor & Francis Group, Boca Raton, Chapter 7. 23. 2005.
 
[13]  Lee K.H., Xiao Z., Podophyllotoxins and analogs. In Anticancer Agents from Natural Products, edited by Cragg GM, Kingston DGI, Newman DJ. Brunner-Routledge Psychology Press, Taylor & Francis Group, Boca Raton, Chapter 5. 71. 2005.
 
[14]  Kingston D. G. I., Taxol and its analogs. In Anticancer Agents from Natural Products, edited by Cragg GM, Kingston DGI, Newman DJ. Brunner-Routledge Psychology Press, Taylor & Francis Group, Boca Raton, Chapter 6. 89. 2005.
 
[15]  Rahier N.J., Thomas C. J., Hecht S. M., Camptothecin and its analogs. In Anticancer Agents from Natural Products, edited by Cragg GM, Kingston DGI, Newman DJ. Brunner-Routledge Psychology Press, Taylor & Francis Group, Boca Raton, Chapter 2. 5. 2005.
 
[16]  Itokawa H., Ibraheim Z. Z, Ya F. Q., Takeya K., Anthraquinones, naphthohydroquinones and naphthohydroquinone dimmers from Rubia cordifolia and their cytotoxic activity. Chemical and Pharmaceutical Bulletin, 41(10). 1869. 1993.
 
[17]  Bhoomika R., Ramesh K. G., Anita A.M., Phyto-pharmacology of Achyranthes aspera: A Review. Pharmacognosy Reviews, 1(1). 143. 2007.
 
[18]  Cha kraborty A., Brantner T., Mukainaka Y., Nobukuni M., Kuchide T., Konoshima H., et al., Cancer chemopreventive activity of Achyranthes aspera leaves on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Cancer letters, 177(1). 1. 2002.
 
[19]  Scharfenberg K., Wagner R., Wagner K.G., The cytotoxic effect of ajoene, a natural product from garlic, investigated with different cell lines. Cancer Letters, 53(2-3). 103. 1990.
 
[20]  Thomson M., Ali M., Garlic (Allium sativum): a review of its potential use as an anti-cancer agent. Current Cancer Drug Targets, 3(1). 67. 2003.
 
[21]  Banasenthil S., Ramachandran C.R., Nagini S., Prevention of 4-nitroquinoline-1-oxide induced rat tongue carcinogenesis by garlic. Fitoterapia, 72. 524. 2001.
 
[22]  Geethangili M., Rao Y. K., Fang S. H., Tzeng Y. M., Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in jurkat cells. Phytotherapy Research, 22(10). 1336. 2008.
 
[23]  Kumar R.A., Sridevi K., Kumar V. N., Nanduri S., Rajagopal S., Anticancer and immunostimulatory compounds from Andrographis paniculata. Journal of Ethnopharmacology, 92(2-3). 291. 2004.
 
[24]  http://www.zhion.com/herb/Andrographis.html. (Accessed on july 28, 2011).
 
[25]  Muriel J. M., Herbs or Natural Products That Decrease Cancer Growth. Oncology Nursing Forum, 31(4). E 75, 2004.
 
[26]  Lannuzel A., Michel P.P., Caparros L. D., Abaul J., Hocquemiller R., Ruberg M., Toxicity of Annonaceae for dopaminergic neurons: Potential role in atypical Parkinsonism in Guadeloupe, Movement Disorders: Official Journal of the movement Disorder Society, 17: 84, (2002).
 
[27]  http://herbalguides.com/guides/graviola. (Accessed on July 12, 2011).
 
[28]  Kamakura M, Sakaki T., A hypopharyngeal gland protein of the worker honeybee Apis mellifera L. enhances proliferation of primary-cultured rat hepatocytes and suppresses apoptosis in the absence of serum. Protein Expr Purif, 45(2). 307. (2006).
 
[29]  Lee Y. J., Kang S. J., Kim B. M., Kim Y. J., Woo H. D., Chung H. W., Cytotoxicity of honeybee (Apis mellifera) venom in normal human lymphocytes and HL-60 cells. Chemical Biology Interaction, 169(3). 189. (2007).
 
[30]  Hamzaoglu I., Saribeyoglu K., Durak H., Karahasanoglu T., Bayrak I., Altug T., et al., Protective covering of surgical wounds with honey impedes tumor implantation. Archives of Surgery, 135. 1414, (2002).
 
[31]  Wang J., Ito H., Shimura K., Enhancing effect of antitumor polysaccharide from Astralagus or Radix hedysarum on C3 cleavage production of macrophages in mice. Department of Pharmacology, Mie University School of Medicine, Japan. MemInst Oswaldo Cruz, 86(2). 159. (1991).
 
[32]  Cho WC, Leung KN. In vitro and in vivo anti-tumor effects of Astragalus membranaceu. Cancer Letters, 252(1). 43. (2007).
 
[33]  William C. S.C., Kwok L. N., In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Letters, 252(1). 48. 2007.
 
[34]  Kumari P., Misra K., Sisodia B.S., Faridi U., Srivastava S., Luqman S., et al., A promising anticancer and antimalarial component from the leaves of Bidens pilosa. Planta Medica, 5(1). 59. 2009.
 
[35]  Sundararajan P., Dey A., Smith A., Doss A.G., Rajappan M., Natarajan S., Studies of anticancer and antipyretic activity of Bidens pilosa whole plant. Africa Health Sciences, 6(1). 27. 2006.
 
[36]  Guang C. Y. Z., Xiang Z. H. F. T., Wei D.C., Da K. G., Xi L. W., Tubeimoside V (1), a new cyclic bisdesmoside from tubers of Bolbostemma paniculatum, functions by inducing apoptosis in human glioblastoma U87MG cells. Bioorganic & Medicinal Chemistry Letters, 16(17). 4575. 2006.
 
[37]  Yu L, Ma R, Wang Y, Nishino H. Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum. Planta Medica, 60 (3). 204. (1994).
 
[38]  Galve-Roperh I., Sanchez C., Cortes M. L., Pulgar T. G., Izquierdo M., Guzman M., Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracullar signal-regulated kinase activation. Nature Medicine, 6. 313. 2000.
 
[39]  Manuel G., Cannabinoids: potential anticancer agents. Nature Reviews Cancer. 2003. 3. 745.
 
[40]  Najjar E. I. N., Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. Oncol Rep, 19(4). 897. 2008.
 
[41]  Ghantous A., Tayyoun A.A., Lteif G. A., Saliba N. A., Gali-Muhtasib G., El-Sabban M., Darwiche N. Purified salograviolide A isolated from Centaurea ainetensis causes growth inhibition and apoptosis in neoplastic epidermal cells. International Journal of Oncology, 32(4). 841. 2008.
 
[42]  Ho Y. C., Yang S.F., Peng C. Y., Chou M. Y., Chang Y. C., Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix etalloproteinases and urokinase-plasminogen activator. Journal of Oral Pathol Medicine, 36. 588. 2007.
 
[43]  Nishikawa T., Nakajima T., Moriguchi M., Jo M., Sekoguchi S., Ishii M. et al., A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins. Journal of Hepatology, 44. 1074. 2006.
 
[44]  Spinella F., Rosano L., Decandia S., Di C.V., Albini A., Elia G., Natali P.G., Bagnato A., Antitumor effect of green tea polyphenol epigallocatechin-3-gallate in ovarian carcinoma cells: evidence for the endothelin-1 as a potential target. Exp Biol Med, 231. 1123. 2006 a.
 
[45]  Spinella F., Rosano L., Di C.V., Decandia S., Albini A., Nicotra M.R., Natali P.G., Bagnato A., Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma. Mol Cancer Therapy, 5. 1483. 2006 b.
 
[46]  Hwang J. T., Ha J., Park I. J., Lee S. K., Baik H. W., Kim Y. M., Park O. J., Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Letters, 247. 115. 2007.
 
[47]  Peng G., Dixon D.A., Muga S. J., Smith T.J., Wargovich M. J., Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. Molecular Carcino, 45. 309. 2006.
 
[48]  Hu Z., Yang Y., Ho P.C., Chan S. Y., Heng P. W., Chan E., Duan W., Koh H.L., Zhou S., Herb-drug interactions: a literature review. Drugs, 65. 1239. 2005.
 
[49]  Kupchan S. M., Baxter R. L., Mezerein: antileukemic principle isolated from Daphne mezereum. Life Science, 187(4177). 652. 1975.
 
[50]  Coyle T., Levante S., Shetler M., Winfield J., In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines. Journal of Neuro-Oncology, 19. 25. 1994.
 
[51]  Gilbert N.E., Reilly J. E., Chang C. J., Lin Y. C., Brueggemeier R.W., Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. Life Sciences, 57. 61. 1995.
 
[52]  Liang X. S., Rogers A. J., Webber C. L., Ormsby T.J., Tiritan M.E., Maltin S.A., et al., Developing the gossypol derivatives with enhanced antitumor activity. Investigational New Drugs, 13. 181. 1995.
 
[53]  Wu D., An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. Drugs, 38 333. 1989.
 
[54]  Gruenwald J., Brendler T., Jaenicke C., Nontvale N.J., PDR for herbal medicines. Medical Economics, 77. 1998.
 
[55]  Newell C.A., Anderson L.A., Hilpson D., Herbal Medicine: A guide for healthcare professionals. Pharmaceutical Press, London. 1996.
 
[56]  Frederico P., Rafael C.D., Dalton D. J., Miriam T. P. L., Nadia R. B., Antioxidant and cytotoxic activities of Centell asiatica. International Journal of Molecular Science, 10. 3713. 2009.
 
[57]  Baby T. D., Kuttan G., Paddikkala. Cytotoxic and antitumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica L. Journal of Ethnopharmacology, 48(1). 53. 1995.
 
[58]  Punturee K., Wild C. P., Vinitketkumneum U. V., Thai medicinal plant modulating nitric oxide and tumour necrosis factor-alpha in J774. 2 mouse macrophages. Journal of Ethnopharmacology, 95(2-3). 183. 2004.
 
[59]  Huang Y. H., Zhang S. H., Zhen R., Xu X. D., Zhen Y. S., Asiaticoside inducing apoptosis of tumour cells and enhancing antitumour activity of vincristin. Ai Zheng, 23(12). 1599. 2004.
 
[60]  Park B.C., Bosire K. O., Lee E. S., Lee Y. S., Kim J. A., Asiatic acid induced apoptosis in SK-MEL-2 human melanoma cells. Cancer Letters, 218(1). 81. 2005.
 
[61]  Alecu M., Ursaciuc C., Halalau F., Photodynamic treatment of basal cell carcinoma and squamous cell carcinoma with hypericin. Anticancer Research, 18, 4651, 1998.
 
[62]  Wada A., Sakaeda T., Takara K., Hirai M., Kimura T., Ohmoto N., et al., Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs. Drug Metabolism & Pharmacokinetics, 17(5). 467. 2002.
 
[63]  Martarelli D., Martarelli B., Pediconi D., Nabissi M.I., Perfumi M., Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice. Cancer Letters, 210(1). 27. 2004.
 
[64]  Garrido-Garrido G., Martinez-Sanchez G., Pardo-Andreu G., Garcia-Rivera D., Hernandez-Casana P., Rodeiro-Guerra I., Guevara-Garcia M., Delgado-Hernandez R., Nunez-Selles A.J., Recent advances in the research & development of an aqueous stem bark extract obtained from Mangifera indica L. Recent Developments in Medicinal Plant Research, 9. 169. 2007.
 
[65]  Tamayo D., Mari E., Gonzalez S., Guevara M., Garrido G., Delgado R., Marchioli R., Nunez A.J., Vimang as natural antioxidant supplementation in patients with malignant tumours. Minerva Medica, 92. 95. 2001.
 
[66]  Nunez A., Castro H., Aguero A.J., Gonzalez J., Naddeo F., De S.F., Rastrelli L., Isolation and quantitative analysis of phenolic antioxidants, free sugars and polyphenols from Mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as a nutritional supplement. Journal of Agriculture Food Chemistry, 50. 762. 2002.
 
[67]  Zhen H. S., Study of anticancer effect in vivo of active fraction from Nervillia fordii.Zhong. Yao Cai, 30(9). 1095. 2007.
 
[68]  Narisa K., Jenny M. W., Heather M. A. C., Cytotoxic Effect of Four Thai Edible Plants on Mammalian Cell Proliferation. Thai Pharmaceutical and Health Science Journal, 1(3). 189. 2006.
 
[69]  Roy M. K., Nakahara K., Na T. V., Trakoontivakorn G., Takenaka M., Isobe S., et al., Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis. A. Pharmazie, 62(2). 149. 2007.
 
[70]  Nakahara K., Onishi K. M., Ono H., Yoshida M., Trakoontivakorn G., Antimutagenic activity against trp-P-1 of the edible Thai Plant: Oroxylum indicum Vent. Bioscience Biotechnology & Biochemistry, 65(10). 2358. 2001.
 
[71]  Tepsuwan A., Furihata C., Rojanapo W., Matsuhima T., Genotoxicity and cell proliferative acitivity of a nitrosated Oroxylum indicum Vent fractioin in the pyloric mucosa of rat stomact. Mutatant Research, 281(1). 55. 1992.
 
[72]  Lotufo L. V. C., Khan M. T. H., Ather A., Wilke D. V., Jimenez P.C., Pessoa C., et al., Studies of the anticancer potential of plants used in Bangladeshi folk medicine. Journal of Ethnopharmacology, 99. 21. 2005.
 
[73]  Kumar R.A., Rajkumar V., Guha G., Mathe L., Therapeutic Potentials of Oroxylum indicum Bark Extracts. Chinese Journal of Natural Medicines, 8(2). 121. 2010.
 
[74]  Jenna K. J., Joy K. L., Kuttan R., Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-Nitrosodiethylamine induced hepatocardinogenesis. Cancer Letters, 136. 11. 1999.
 
[75]  Morita H., Yamamiya T., Takeya K., Itokawa H., New antitumour bicyclic hexapeptides, RA-IX, XII, XIII and XIV from Rubia cordifolia. Chemical and Pharmaceutical Bulletin, 40(5). 1352 S. 1992.
 
[76]  Morita H., Yamamiya T., Takeya K., Conformational Recognition of RA – XII by 80S ribosomes: a different line broadening study in 1H NMR spectroscopy. Chemical and Pharmaceutical Bulletin, 41(4). 781. 1993.
 
[77]  Itokawa H., Wang X., Lee K. H., Homoharringtonine and related compounds, in Anticancer Agents from Natural Products. Edited by Cragg GM, Kingston DGI, Newman DJ. Brunner-Routledge Psychology Press, Taylor & Francis Group, Boca Raton, Chapter 4, 47. 2005.
 
[78]  Gupta P.P., Srimal R. C., Verma N., Tandon J. S., Biological Activity of Rubia cordifolia and Isolation of an Active Principle. Pharmaceutical Biology, 37(1). 46. 1999.
 
[79]  Abderrahman S. M., Mitodepressive Effect of Rubia cordifolia Extract on the Bone Marrow Cells of Mice. Cytologia, 69(3). 307. 2004.
 
[80]  Son J. K., Jung J. H., Lee C. S., Moon D.C., Choi S.W., Min B.S., Woo M. H., DNA Topoisomerases I and II Inhibition and Cytotoxicity of Constituents from the Roots of Rubia cordifolia. Chem Inform, 38(2). 15. 2006.
 
[81]  Nizamutdinova I. T., Lee G. W., Lee J. S., Cho M. K., Son K. H., Jeon S. J. et al., Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA- MB- 231, through regulation of adhesion molecules. Carcinogenesis, 29(10). 1885. 2008.
 
[82]  Yoon Y., Kim Y., Jeon W. K., Park H.J., Sun H.J., Tanshinone IIA isolated from Salvia miltiorrhiza B. induced apoptosis in HL60 human premyelocytic leukemia cell line. Journal of Ethnopharmacology, 68(1-3). 121. 1999.
 
[83]  Parajuli P., Joshee N., Rimando A.M., Mittal S., Yadav S. K., In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids. Planta Medica, 75(1). 41. 2009.
 
[84]  Yin X., Zhou J., Jie C., Xing D., Zhang Y., Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A 549. Life Sciences, 17. 75(18). 2233. 2004.
 
[85]  Wang X., Wei Y., Yuan S., Liu G., Lu Y., Zhang J., Wang W., Potential anticancer activity of tanshinone II A against human breast cancer. International Journal of Cancer, 116. 799. 2005.
 
[86]  Lee C. Y., Sher H.F., Chen H. W., Liu C.C., Chen C. S., Lin C. S., Yang P.C., Tsay H. S, Chen J. J. W., Anticancer effects of tanshinone I in human non-small cell lung cancer. Molecular Cancer Therapy, 7. 3527. 2008.
 
[87]  Ye F., Xui L., Yi J., Zhang W., Zhang D. Y., Anticancer activity of Scutellaria baicalensis and its potential mechanism. Journal of Alternative & Complementary Medicine, 8(5). 567. 2002.
 
[88]  Zahra T. N., Emami S.A., Asili J., Mirzaei A., Mousavi S. H., Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. Available at http://ecam.oxfordjournals.org/cgi/content/full/nep214 (accessed on July 22, 2010).
 
[89]  Katiyar S. K., Korman N.J., Mukhtar H., Agarwal R., Protective effects of silymarin against photocarcinogenesis in a mouse skin model. Journal of National Cancer Institute, 89(8). 556. 1997.
 
[90]  Agarwal R., Agarwal C., Ichikawa H., Singh R.P., Agarwal B.B., Anticancer potential of silymarin: from bench to bed side. Anticancer Research, 26(6B). 4457. 2006.
 
[91]  Kim S., Choi J. H., Lim H. I., Lee S. K., Kim W.W., Kim J. S., et al., Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells, Phytomedicine, 16(6-7). 573. 2009.
 
[92]  Li Y. L., Gan G. P., Zhang H. Z., Wu H. Z., Li C. L., Huang Y. P., Liu Y. W., Liu J. W., A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines. Journal of Ethnopharmacology, 113(1). 115. 2007.
 
[93]  Xu W., Liu J., Li C., Wu H. Z., Liu Y. W., Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53- independent manner. Cancer Letters, 264(2). 229. 2008.
 
[94]  Yuan L.L., Guo P. G., Hui Z. Z., He Z. W., Chang L.L., Yong P. H., et al., A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines. Journal of Ethnolpharmacology, 113. 115-124. 2007.
 
[95]  Xu K. D., Wu Y., Wei D. L., Fang Z. Y., Xiao Y. L., Xiao C. Z., Zi C. Z., Bao C.C., The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism. Journal of Ethnopharmacology, 106(2). 179. 2006.
 
[96]  Rao P.S., Ramanadham M., Prasad M. N., Anti-proliferative effects of Syrychnos nux-vomica root extract on human multiple myeloma cell line- RPMI 8226. Food & Chemical Toxicology, 47(2). 283. 2009.
 
[97]  Sigstedt S.C., Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. International Journal of Oncology. 32(5). 1085. 2008.
 
[98]  Hyun N. K., Seung H.H., Bong K. S., Cheorl H. K., Young H. Y., Hyung M. K., Taraxacum officinale induces cytotoxicity through TNF-α and IL-1α secretion in Hep G2 cells. Life Sciences, 74(9). 1149. 2004.
 
[99]  Kaur S., Grover I. S., Singh M., Kaur S., Antimutagenesity of hydrolyzable tannins from Terminalia chebula in Salmonella typhimerium. Mutagen Research, 419(1-3). 169. 1998.
 
[100]  Arora S., Kaw K., Kaur S., Indian Medicinal Plants as reserver of protective phytochemicals, Tetragenesis. Carcinogenesis and Mutagenesis, 23(1). 295. 2003.
 
[101]  Saleem M., Hushum M., Harkonen P., Pihlaja K., Inhibition of cancer cell growth by crude extract and phenolics of Terminalia chebula fruit. Journal of Ethnopharmacology, 81. 327. 2002.
 
[102]  Lecia J. G., Jetaime R., Ernest B. I., Vernonia amygdalina: Anticancer activity, Authentication, and Adultration detection. International Journal of Environment Research: Public Health, 5(5). 342. 2008.
 
[103]  Ali M., Shuaib M., Withanolides from the stem bark of Withania somnifera. Phytochemistry, 44(6). 1163. 1997.
 
[104]  Chakraborti S. K., De B. K., Bandyopadhyay T., Variations in the Antitumor Constituents of Withania somnifera. Experientia, 30(8). 852. 1974.
 
[105]  Devi P. U., Akagi K., Ostapenko V., Tanaka Y., Sugahara T., Withaferin A: a new radiosensitizer from the Indian medicinal plant Withania somnifera. International Journal of Radiational Biology, 69(2). 193. 1996.
 
[106]  Prakash J., Gupta S. K., Dinda A. K., Withania somnifera root extract prevents DMBA-induced squamous cell carcinoma of skin in Swiss albino mice, Nutr. Cancer, 42(1). 91. 2002.
 
[107]  Jayaprakasam B., Zhang Y., Seeram N., Nair M., Growth inhibition of tumor cell lines by withanolides from Withania somnifera leaves. Life Sciences, 74(1). 125. 2003.
 
[108]  Singh N., Singh S.P., Nath R., Prevention of urethane-induced lung adenomas by Withania somnifera (L.) Dunal in albino mice. International Journal of Crude Drug Research, 24. 90. 1986.
 
[109]  Gupta Y. K., Sharma S.S., Rai K., Katiyar C. K., Reversal of paclitaxel induced neutropenia by Withania somnifera in mice. Indian Journal of Physiology & Pharmacology, 45(2). 253. 2001.
 
[110]  Katiyar S. K., Agarwal R., Mukhtar H., Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. Cancer Research, 56(5). 1023. 1996.
 
[111]  Brown A. C., Ginger’s inhibition of rat colonic adenocarcinoma cells proliferation angiogenesis in vitro. Phytotherapy Research, 32. 2008.
 
[112]  Abdullah S., Abidin S. A. Z., Murad N. A., Suzana M., Ngah W. Z. W., Yusof Y. A. M., Ginger extract (Zingiber officinale) triggers apoptosis and G0/G1 cells arrest in HCT 116 and HT 29 colon cancer cell lines. African Journal of Biochemistry Research, 4(4). 134. 2010.
 
[113]  Willaman J.J., Hui-Li L., Lloydia, 33(3A). 1. 1970.
 
[114]  Sehgal R., Roy S., Kumar V. L., Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allium cepa root model. Biocell, 30(1). 9. 2006.
 
[115]  Foss P., Ellipticine: An indole alkaloid isolated from Ochrosia ellipitica. Molecular Pharmacology, 42. 590. 1992.
 
[116]  Hong R. L., Spohn W. H., Hung M. C., Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p 185neu. Clinical Cancer Research, 5. 1884. 1999.
 
[117]  Gerald R., Palesa N., The natural abundance of L-Canavanine, an active anticancer agent, in alfaalfa, Medicago sativa (L.). Laboratory of Biochemical Ecology, University of Kentucky, Lexington, USA.
 
[118]  Madhuri L., Pandey G., Some anticancer medicinal plants of foreign Origin. Current Science, 96(6). 25. 779. 2009.
 
[119]  Desai A.G., Medicinal plants and cancer chemoprevention. Curr Drug Metabolism, 9(7). 581. 2008.
 
[120]  Mohammad S., Anticancer agents from medicinal plants. Bangladesh Journal of Pharmacology, 1. 35. 2006.
 
[121]  Kelland L. R., Flavopiridol, the first cyclic-dependent kinase inhibitor to enter the clinic: current status. Expert Opinion Investigational Drugs, 9. 2903. 2000.
 
[122]  Christian M. C., Pluda J. M., Ho T. C., Arbuck S. G., Murgo A. J., Sausville E. A., Promising new agents under development by division of cancer treatment, diagnosis, and centers of the National Cancer Institute. Semin Oncology, 13. 2643. 1997.
 
[123]  Meijer L., Raymond L., Roscovitine and other purines as kinase inhibitors: From starfish oocytes to clinical trials. Accounts Chem Res, 36. 417. 2003.
 
[124]  Pettit G. R., Singh S. B., Niven M. L., Hamel E., Schmit J. M., Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum. Journal Natural Products, 50. 119. 1987.
 
[125]  Pettit G. R., Singh S. B., Boyd M. R., Hamel E., Pettit R., Schmit J. M. et al. Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5 and A-6. Journal of Med Chem, 38. 1666. 1995.
 
[126]  Ohsumi K., Nakagawa R., Fukuda Y., Hatanaka T., Morinaga Y., Nihei Y. et al. New combretastatin analogues effective against murine solid tumors: design and structure-activity relationship. Journal of Med Chem, 41. 705. 1998.
 
[127]  Cichewitz R. H., Kouzi S.A., Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Medical Research Reviews, 24. 90. 2004.
 
[128]  Pisha E., Chai H., Lee I. S., Chagwedera T. E., Farnsworth N. R., Cordell G. A. et al. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Natural Medicine, 1. 1046. 1995.
 
[129]  Nahar N., Das R.N., Shoeb M., Marma M.S., Aziz M.A., Mosihuzzaman M., Four triterpenoids from the bark of Zizyphus rugosa and Z. oenoplia. Journal of Bangladesh Academy of Science, 21. 151. 1997.
 
[130]  Balunas M. J., Kinghorn A. D. Drug discovery from medicinal plants. Life Sciences, 78. 431. 2005.
 
[131]  Silva G. L., Cui B., Chavez D., You M., Chai H.B., Rasoanaive P. et al., Modulation of the multidrug-resistance phenotype by new tropane alkaloids aromatic esters from Erythroxylum pervillei. Journal of Natural Products, 64. 1514. 2001.
 
[132]  Mi Q., Cui B., Silva G.L., Lantvit D., Lim E., Chai H. et al., A novel tropane alkaloid that reverses the multidrug-resistance phenotype. Cancer Research, 61. 842. 2001.
 
[133]  Mi Q., Cui B., Silva GL, Lantvit D, Lim E, Chai H et al.,A new tropane alkaloid aromatic ester that reverses the multidrug-resistance phenotype. Anticancer Research, 23. 3607. 2003.
 
[134]  Hwang B. Y., Su B.N., Chai H., Mi Q., Kardono L.B., Afriastini JJ et al., Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaila silvestris. Journal of Organic Chemistry, 69. 3350. 2004.
 
[135]  Shoeb M., Celik S., Jaspars M., Kumarasamy Y., MacManus S., Nahar L. et al., Isolation, structure elucidation and bioactivity of schischkiniin, a unique indole alkaloid from the seeds of Centaurea schischkinii. Tetrahedron, 61. 9001. 2005.
 
[136]  Altmann K. H., Cachoux F., Feyen F., Gertsch J., Kuzniewski C. N., Wartmann M., Natural products as leads for anticancer drug discovery: discovery of new chemotypes of microtubule stabilizers through reengineering of the epothilone scaffold, Chimia (Aarau), 64(1-2), 8-13, 2010.