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American Journal of Public Health Research. 2018, 6(1), 11-17
DOI: 10.12691/ajphr-6-1-3
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Effects of Isoflurane Exposure to Fertility through Estrogen Gene Expression in Operating Room Nurses

Rika Handayani1, Tahir Abdullah2, Furqaan Naiem3, Anwar Mallongi4, Rahmat Haji Saeni5, Ekayanti Hafidah Ahmad6 and Prihantono Prihantono7,

1Syekh Yusuf Academy of Midwifery, Makassar, Indonesia

2Departement of Reproductive Health and Family, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia

3Department of Occupational Health, School of Public Health, Hasanuddin University, Makassar, Indonesia

4Departement of Environmental Health, School of Public Health, Hasanuddin University, Makassar, Indonesia

5Departement of Nutrition, Polytechnic of Health, Mamuju, Indonesia

6Makassar Nursing Academy, Makassar, Indonesia

7Departement of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Pub. Date: January 22, 2018

Cite this paper:
Rika Handayani, Tahir Abdullah, Furqaan Naiem, Anwar Mallongi, Rahmat Haji Saeni, Ekayanti Hafidah Ahmad and Prihantono Prihantono. Effects of Isoflurane Exposure to Fertility through Estrogen Gene Expression in Operating Room Nurses. American Journal of Public Health Research. 2018; 6(1):11-17. doi: 10.12691/ajphr-6-1-3


Background. Operating room is one of the many workplace hazards. In the operating room nurses and other health personnel at risk of exposure to chemicals. One type of inhalation anesthetic gas that is isoflurane (foran, aeran). Isoflurane a halogenated hydrocarbon compounds volatile ether. Exposure to halogenated anesthetic gases can result in effects on reproductive health. Method. The study design used is Retrospective cohort, with a sample size of 16 exposed and 16 unexposed. Mechanical sampling random sampling. Data analysis used independent t-test. Results. The results showed that exposure status isoflurane effect on fertility disorder where there are differences in average significantly between hormone gene expression estrogen the exposed group (9.35 ± 1.78) and unexposed (11.65 ± 1.44) with values p = 0.013 (p < 0.05). The tenure of the effect on fertility disorder where there are differences in average significantly between the tenure of the hormone gene expression estrogen namely the working period of 5-9 years (11.84 ± 1.16) and ≥10 years (8.52 ± 0.94) with values p = 0.006 ( p < 0.05). Hormone gene expression estrogen effect on fertility disorder where there are differences in average significantly between hormone gene expression estrogen against fertility disorder that nurses are experiencing hormonal changes in gene expression estrogen risk of impaired fertility (8.52 ± 0.94) and that did not change hormone gene expression estrogen not at risk of reduced fertility (11.69 ± 1.33) with values p = < 0.001 (p < 0.05). Conclusion: Based on this it is expected that the Health and Safety at Work Hospital perform periodic monitoring the work environment primarily in the operating room.

exposure status isoflurane work period hormone gene expression estrogen and fertility disorders

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