American Journal of Public Health Research
ISSN (Print): 2327-669X ISSN (Online): 2327-6703 Website: Editor-in-chief: Apply for this position
Open Access
Journal Browser
American Journal of Public Health Research. 2015, 3(5), 187-191
DOI: 10.12691/ajphr-3-5-2
Open AccessArticle

Food Anaphylaxis: Reported Cases in Russian Federation Children

Natalia Vladislavovna Esakova1, , Marina Sergeevna Treneva1, Tatyana Sergeevna Okuneva1 and Alexander Nikolaevich Pampura1,

1Allergy and Clinical Immunology Department, Research and Clinical Institute for Pediatrics at the Pirogov Russian National Research Medical University, Moscow, Russia

Pub. Date: September 11, 2015

Cite this paper:
Natalia Vladislavovna Esakova, Marina Sergeevna Treneva, Tatyana Sergeevna Okuneva and Alexander Nikolaevich Pampura. Food Anaphylaxis: Reported Cases in Russian Federation Children. American Journal of Public Health Research. 2015; 3(5):187-191. doi: 10.12691/ajphr-3-5-2


Background: Anaphylaxis is a potentially fatal allergic reaction. Food allergy is one of the main causes of anaphylaxis in children. Anaphylaxis research in different populations across Europe is one of the unmet needs. The aim of this study is to evaluate typical clinical features, causes of food anaphylaxis and sensitization to food allergens in Russian Federation children admitted to the allergy department. Materials and methods: Allergy history of 80 children with food anaphylaxis was investigated and specific IgE concentration in serum was tested. Results: Total number of anaphylaxis episodes in 80 children was 158. Family allergy history was positive in 42 children. Food anaphylaxis episodes were associated more often with cow milk, fish or/and seafood, tree nuts. Cow milk was reliably more valid in children under 2 years of age than in older children, where tree nut and fruit anaphylaxis was more frequent. Specific IgE levels ≥ 0,35 кUA/l to food associated with anaphylaxis episodes were revealed in all children and varied largely. Specific IgE levels did not correlate with severity of anaphylaxis episodes.Clinical manifestations with skin/mucosa and respiratory system involvement were the most frequent (97,5% and 92% respectively). Cardiovascular and gastrointestinal systems were involved in 33,5% of cases each. Conclusion: Cow milk, fish and/or seafood, tree nuts are the most often food associated with food anaphylaxis cases in Russian Federation children. Food triggers of anaphylaxis vary with age of children. Skin/mucosa and respiratory tract are often involved in food anaphylaxis episodes. Cardiovascular involvement increases with children’s age.

anaphylaxis children infants food

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Muraro A, Werfel T, Hoffmann-Sommergruber K, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy 2014:69(8):1008-1025.
[2]  Panesar SS, Javad S, de Silva D, et al. The epidemiology of anaphylaxis in Europe: a systematic review. Allergy 2013:68(11):1353-1361.
[3]  Rolla G, Mietta S, Raie A, et al. Incidence of food anaphylaxis in Piemonte region (Italy): data from registry of Center for Severe Allergic Reactions. Intern Emerg Med 2013:8(7):615-620.
[4]  Castells MC. Anaphylaxis and Hypersensitivity Reactions. Humana Press. New York 2011: 376 p.
[5]  Simons FE, Ardusso LR, Dimov V, et al. World Allergy Organization. World Allergy Organization Anaphylaxis Guidelines: 2013 update of the evidence base. Int Arch Allergy Immunol 2013:162(3):193-204.
[6]  Liew W.K. Chiang W.C., Goh A.E. et al. Paediatric anaphylaxis in a Singaporean children cohort: changing food allergy triggers over time. Asia Pac Allergy 2013:l3(1):29-34.
[7]  Gaspar-Marques J, Clark S, Pelletier AJ, Camargo CA. Food Allergy and Anaphylaxis in Infants and Preschool-Age Children. Clin Pediatr (Phila) 2014:53(7):652-657.
[8]  Park M, Kim D, Ahn K, Kim J, Han Y. Prevalence of immediate-type food allergy in early childhood in seoul. Allergy Asthma Immunol Res 2014:6(2):131-136.
[9]  Decker WW, Campbell RL, Manivannan V, et al. The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project. J Allergy Clin Immunol 2008:122(6):1161-1165.
[10]  Papadopoulos NG, Agache I, Bavbek S, et al. Research needs in allergy: an EAACI position paper, in collaboration with EFA. Clin Transl Allergy 2012:2(1):21.
[11]  Muraro GR, Roberts G, Clark A, et al. The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology. Allergy 2007: 62(8): 857-871.
[12]  Stelmach I, Bobrowska-Korzeniowska M, Smejda K, et al.. Risk factors for the development of atopic dermatitis and early wheeze. Allergy Asthma Proc 2014:35(5):382-389.
[13]  Illi S, Weber J, Zutavern A, Genuneit J, Schierl R, Strunz-Lehner C, von Mutius E. Perinatal influences on the development of asthma and atopy in childhood. Ann Allergy Asthma Immunol 2014:112(2):132-139.
[14]  Wen HJ, Chiang TL, Lin SJ, Guo YL. Predicting risk for childhood asthma by pre-pregnancy, perinatal, and postnatal factors. Pediatr Allergy Immunol 2015:26(3):272-279.
[15]  Novembre E, Cianferoni A, Bernardini R et al. Anaphylaxis in children: clinical and allergologic features. Pediatrics 1998: 101(4): 8.
[16]  De Silva IL, Mehr SS, Tey D, Tang ML. Paediatric anaphylaxis: a 5-year retrospective review. Allergy 2008:63(8):1071-1076.
[17]  Silva R, Gomes E, Cunha L, Falcão H. Anaphylaxis in children: a nine years retrospective study (2001-2009). Allergol Immunopathol 2012:40(1):31-36.
[18]  Saeideh B, Akramian R, Pourpak Z, et al. Common Causes of Anaphylaxis in Children The First Report of Anaphylaxis Registry in Iran. WAO Journal 2010: 3(1): 9-13.
[19]  Rudders SA, Banerji A, Clark S, et al. Age-related differences in the clinical presentation of food-induced anaphylaxis. J Pediatr 2011:158(2):326-328.
[20]  Huang F, Chawla K, Järvinen KM, Nowak-Węgrzyn A. Anaphylaxis in a New York City pediatric emergency department: Triggers, treatments, and outcomes. J Allergy Clin Immunol 2012:129(1):162-168.
[21]  Vezir Е, Erkoçoğlu M, Kaya A, et al. Characteristics of anaphylaxis in children referred to a tertiary care center. Allergy Asthma Proc. 2013:34(3):239-246.
[22]  Mehl A, Wahn U, Niggemann B. Anaphylactic reactions in children – a questionnaire-based survey in Germany. Allergy 2005:60(11):1440-1445.
[23]  Piromrat K, Chinratanapisit S, Trathong S. Anaphylaxis in an emergency department: a 2-year study in a tertiary-care hospital. Asian Pac J Allergy Immunol 2008:26(2-3):121-128.
[24]  Hsin, YC, Huang JL, Yeh KW. Clinical features of adult and pediatric anaphylaxis in Taiwan. Asian Pac J Allergy Clin Immunol 2011:29(4):307-312.
[25]  Lieberman P, Nicklas RA, Oppenheimer J et al. The diagnosis and management of anaphylaxis practicparameter: 2010 Update. J Allergy Clin Immunol 2010:126(3):477-480.