American Journal of Public Health Research
ISSN (Print): 2327-669X ISSN (Online): 2327-6703 Website: http://www.sciepub.com/journal/ajphr Editor-in-chief: Apply for this position
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American Journal of Public Health Research. 2015, 3(3), 95-99
DOI: 10.12691/ajphr-3-3-3
Open AccessArticle

Аllergies in Families of Moscow (Russia) Newborns: Suspected Cases within Three Generations Framework

Мarina Treneva1, , Alexander Pampura1 and Daniel Munblit2

1Allergy and Clinical Immunology Unit, Research and Clinical Institute for Pediatrics at the Pirogov Russian National Research Medical University, Moscow, Russia

22Department of Paediatrics, Imperial College London, London, United Kingdom

Pub. Date: April 21, 2015

Cite this paper:
Мarina Treneva, Alexander Pampura and Daniel Munblit. Аllergies in Families of Moscow (Russia) Newborns: Suspected Cases within Three Generations Framework. American Journal of Public Health Research. 2015; 3(3):95-99. doi: 10.12691/ajphr-3-3-3

Abstract

Background: Allergy prevalence in parents of newborns is an indicator of allergic diseases in children, which is split upon parent’s gender and allergic conditions. Objective: to find out gender patterns within a larger framework of allergies in grandparents, aunts, uncles of newborns in maternal and paternal families. Methods: In 2011 13 visits to the Postnatal Department of Moscow No.1 Maternity Hospital were carried out. All women delivered within the preceding 48 hours were interviewed. Mothers provided us with information on relatives of a newborn in regards to clinical manifestations of food allergies, atopic dermatitis, eczema, urticaria, angioedema, allergic rhinitis, allergic conjunctivitis, asthma and episodes of drug allergy. Information on 3534 relatives from 393 newborns was collected. Results: The rate of suspected allergic conditions in grandfathers is the same in both maternal and paternal families (4,35% 95%CI 1,99-6,70 and 4,62% 95%CI 2,12-7,12 respectively), but in grandmothers and aunts the rate of suspected allergic incidence is increased in maternal family (11,54% 95%CI 8,58-14,50) over paternal (6,80% 95%CI 4,46-9,14). The cumulative rate of suspected allergies in grandfathers+fathers+uncles (i.e. in male relatives of two preceding the newborns generations) is significantly lower (8,57% 95%CI 7,03-10,11) than in grandmothers+mothers+aunts (i.e. in female relatives of two preceding the newborns generations) (13,28% 95%CI 11,44-15,13) (p < .05). Conclusion: There are clear gender differences with increased prevalence of suspected allergic conditions in female relatives of two preceding the newborn generations compared with male relatives. There is a tendency to increased suspected allergic manifestations among women of maternal relatives in comparison to paternal relatives.

Keywords:
allergy newborns relatives parents grandparents cousins siblings uncles aunts prevalence

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References:

[1]  Wen H-J, Wang Y-J, Lin Y-C, Chang C-C, Shieh C-C, Lung F-W et al. Prediction of atopic dermatitis in 2-yr-old children by cord blood IgE, genetic polymorphisms in cytokine genes, and maternal mentality during pregnancy. Pediatr Allergy Immunol 2011:22; 695-703.
 
[2]  Kynyk JA, Mastronarde JG, McCallister JW. Asthma, the sex difference. Curr Opin Pulm Med 2011; 17(1):6-11.
 
[3]  Lødrup Carlsen KC, Söderström L, Mowinckel P, Håland G, Pettersen M, Munthe Kaas et al. Asthma prediction in school children; the value of combined IgE-antibodies and obstructive airways disease severity score. Allergy 2010; 65(9):1134-40.
 
[4]  Arshad SH, Karmaus W, Raza A, Kurukulaaratchy RJ, Matthews SH, Holloway JW et al. The effect of parental allergy on childhood allergic diseases depends on the sex of the child. J Allergy Clin Immunol 2012; 130:427-34.
 
[5]  Treneva MS. Allergic diseases primary prevention children setting: positive predictive value and high specificity of information on allergic diseases in male relatives. Russian Allergy Journal 2010; 6:34-37.
 
[6]  Kanny G, Moneret-Vautrin DA, Flabbee J, Beaudouin E, Morisset M, Thevenin F. Population study of food allergy in France. J Allergy Clin Immunol. 2001; 108(1):133-40.
 
[7]  Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006;355(21): 2226-35.
 
[8]  Brauer M, Hoek G, Smit HA, de Jongste JC, Postma DS, Kerkhof M et al. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J 2007; 29:879-88.
 
[9]  Heinrich J, Wichmann HE. Traffic related pollutants in Europe and their effect on allergic disease. Curr Opin Allergy Clin Immunol 2004;4:341-8.
 
[10]  Treneva MS, Pampura AN. Allergic disease probability in children with relatives’ allergic manifestations. Russian Allergy Journal 2006; 3: 40-43.