American Journal of Public Health Research
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American Journal of Public Health Research. 2021, 9(3), 90-95
DOI: 10.12691/ajphr-9-3-1
Open AccessArticle

Good Participatory Practice, Clinical Trials Awareness and COVID-19 Vaccine Acceptance in Sub-Sahara Africa

Bernadette Ateghang-Awankem1, , Laura DeLuca2, Edwin Shadzeka3 and Kenneth Yongabi Anchang4

1Menda Health Systems, African Women 4 Empowerment, Nussloch, Germany

2Instructor in Math, Social Science and Statistics First Year Academic Experience, University of Colorado-Boulder

3Medicine and Health Sciences, School of Business, George Washington University, Washington, D.C

4Faculty of Health Science, College of Medicine, Imo State University, Owerri, Nigeria

Pub. Date: March 28, 2021

Cite this paper:
Bernadette Ateghang-Awankem, Laura DeLuca, Edwin Shadzeka and Kenneth Yongabi Anchang. Good Participatory Practice, Clinical Trials Awareness and COVID-19 Vaccine Acceptance in Sub-Sahara Africa. American Journal of Public Health Research. 2021; 9(3):90-95. doi: 10.12691/ajphr-9-3-1

Abstract

The success stories regarding the availability of at least 4 coronavirus disease 2019 (COVID-19) vaccines showing efficacy rates of about 90%, barely 10 months after the sequence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was made available by China and 8 months after the World Health Organization (WHO) declared the COVID-19 pandemic, is an incredible scientific and technological achievement. Clear and consistent communication by the pharmaceutical industry, national and regional medicinal agencies, and government officials is key to building public confidence in vaccine programs. In addition, community-based care with community health workers will increase efficacy. This includes clinical trials and regulatory process awareness campaign. Additionally, strategic campaigns should also address COVID-19 vaccine-related issues: Vaccine’s level of efficacy, number of shots/doses needed, the time needed for protection, vaccine up-take, and herd immunity. Implementing the principles of good participatory practice and stakeholder engagement prior to market launch, is essential, to improve vaccine acceptance.

Keywords:
stakeholder engagement COVID-19 clinical trials vaccine acceptance

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  J. V. Lazarus, S. C. Ratzan, A. Palayew, L. O. Gostin, H. J. Larson, K. Rabin, S. Kimball and A. El-Mohandes, “A global survey of potential acceptance of a COVID-19 vaccine,” Nature Medicine, 20 October 2020.
 
[2]  T. K. Burki, “The Russian vaccine for COVID-19.,” Lancet Respir. Med., 4 September 2020.
 
[3]  Pfizer, “www.pfizer.com,” Pfizer, 09 November 2020. [Online]. Available: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against. [Accessed 18 November 2020].
 
[4]  Moderna, “Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study,” Moderna, USA, 2020.
 
[5]  AstraZenecca, 23 Vovember 2020. [Online]. Available: https://www.astrazeneca.com/media-centre/press-releases/2020/azd1222hlr.html.
 
[6]  Felter, “A Guide to global COVID-19 efforts,” https://www.cfr.org/backgrounder/guide-global-covid-19-vaccine-efforts, February 5, 2021.
 
[7]  B. Angela, “New study shares preliminary data on Pfizer vaccine’s effectiveness in Israel.aspx,” https://www.news-medical.net/news/20210211/, Feb 11 2021.
 
[8]  K. Tom, “European doctors shun oxford-astrazeneca vaccine amid reports of side effects,” https://www.thetimes.co.uk/article/, Saturday February 13 2021.
 
[9]  C. John, “South Africa suspends use of AstraZeneca’s COVID-19 vaccine after it fails to clearly stop virus variant,” https://www.sciencemag.org/news/2021/02/south-africa-suspends-use-astrazenecas-covid-19-vaccine-after-it-fails-clearly-stop,, Accessed 8 Feb.
 
[10]  Astrazeneca, “COVID-19 Vaccine AstraZeneca confirms 100% protection against severe disease, hospitalisation and death in the primary analysis of Phase III trials,” https://www.astrazeneca.com/media-centre/press-releases/2021/, Accessed 3rd february, 2021.
 
[11]  C. Michelle, “What Are the Side Effects of COVID-19 Vaccines?” https://www.aarp.org/health/conditions-treatments/info-2020/coronavirus-vaccine-side-effects.html, Updated February 4, 2021.
 
[12]  H. Tim, “UK health regulator issues report on side effects of COVID-19 vaccines,” https://newseu.cgtn.com/news/2021-02-06/, February 6, 2021.
 
[13]  Reuters staff, “China approves Sinovac Biotech COVID-19 vaccine for general public use,” https://www.reuters.com/article/us-health-coronavirus-vaccine-sinovac-idUSKBN2A60AY, February 6, 2021.
 
[14]  “Coalition for Epidemic Preparedness Innovations. Manufacturing survey results analysis. June 29, 2020.” https://cepi.net/wp-content/uploads/2020/08/CEPI_Survey-of-global-drug-substance-and-drugproduct-landscape-June-2020_RELEASED-1.pdf, (accessed Feb 6, 2021.
 
[15]  M. Enserink and J. Cohen, “Fact-checking Judy Mikovits, the controversial virologist attacking Anthony Fauci in a viral conspiracy video,” Science, 8 May 2020.
 
[16]  W. Cornwall, “Officials gird for a war on vaccine misinformation,” Science, o3 July.
 
[17]  M. Fadda, E. Albanese and L. S. Suggs, “When a COVID-19 vaccine is ready, will we all be ready for it?,” Int. J. Public Health, p. 711-712, 11 June 2020.
 
[18]  WHO, “172 countries and multiple candidate vaccines engaged in COVID-19 vaccine Global Access Facility,” 24 August 2020. [Online]. Available: https://www.who.int/news/item/24-08-2020-172-countries-and-multiple-candidate-vaccines-engaged-in-covid-19-vaccine-global-access-facility.
 
[19]  GAVI, “172 Countries multiple candidate Vaccines engaged in covid-19-vaccine Global Access,” 4 Semptember 2020. [Online]. Available: https://www.gavi.org/news/media-room/172-countries-multiple-candidate-vaccines-engaged-covid-19-vaccine-global-access. [Accessed 26 November 2020].
 
[20]  BBC, “Covid Vaccine: WHO warns of ‘catastrophic moral failure’,” https://www.bbc.com/news/world-55709428, 18th January, 2021.
 
[21]  U. AD., “COVID-19 vaccines for all?,” Lancet, 2020; 395: 1822-23.
 
[22]  T. Lancet, “Global governance for COVID-19 vaccines,” Lancet, 2020; 395: 1883.
 
[23]  T. EIU, “Africa faces major obstacles to accessing Covid vaccines,” https://www.eiu.com/n/africa-faces-major-obstacles-to-accessing-covid-vaccines/, 25th Janauary, 2021.
 
[24]  M. O. Folayan, B. Brown, B. Haire, C. P. Babalola and N. Ndembi, “Considerations for stakeholder engagement and COVID-19 related clinical trials’ conduct in sub-Saharan Africa,” Wiley Online Library, 15 August 2020.
 
[25]  C. Hebenstreit, “How Technology Is Helping Increase Diversity In Clinical Trials,” Forbes Technology Council, 18 June 2020. [Online]. [Accessed 25 November 2020].
 
[26]  H. J. Riordan, D. Matheson, N. E. Drosopoulou and A. Khera, “Ensuring Diversity in COVID-19 Vaccine Registration Trials,” Journal for Clinical Studies, pp. https://www.jforcs.com/ensuring-diversity-in-covid-19-vaccine-registration-trials/, 16 October 2020.
 
[27]  African CDC, “2020,” African Union, https://au.int/sites/default/files/documents/39350-doc-africa_cdc_consortium_for_covid-19_clinical_trials_-_eng.pdf, August.
 
[28]  M. Makoni, “COVID-19 vaccine trials in Africa,” The Lancet Respiratory Medicine, 04 September 2020.
 
[29]  Oxford University, “Trial of Oxford COVID-19 vaccine in South Africa begins,” 1 July 2020. [Online]. Available: https://www.ovg.ox.ac.uk/news/trial-of-oxford-covid-19-vaccine-in-south-africa-begins. [Accessed 24 November 2020].
 
[30]  E. Henderson, “News Medical Lifesciences,” 17 August 2020. [Online]. Available: https://www.news-medical.net/news/20200817/Wits-University-begins-South-African-trial-of-Novavax-COVID-19-vaccine.aspx. [Accessed 24 November 2020].
 
[31]  P. Karugaba and A. Kenyangi, “www.Mondaq.com,” MONDAQ, 02 July 2020. [Online]. Available: https://www.mondaq.com/food-and-drugs-law/960844/uganda-high-court-sets-guidelines-for-informed-consent-required-during-clinical-trials. [Accessed 18 November 2020].
 
[32]  P. Kaleebu, “www.trialsitenews.com,” TrialSite News, 11 August 2020. [Online]. Available: https://www.trialsitenews.com/imperial-college-of-london-vaccine-to-be-tested-in-uganda-by-december-2020/. [Accessed 18 November 2020].
 
[33]  R. Kevin, “Oxford Covid vaccine has 10% efficacy against South African variant, study suggests,” https://www.theguardian.com/world/2021/feb/08/ oxford-covid-vaccine-10-effective-south-african-variant-study, Accessed 8 Feb, 2021.
 
[34]  Editorial, “COVID-19 vaccines: no time for complacency,” The Lancet, 21 November 2020.
 
[35]  WHO, “Good participatory practice guidelines for trials of emerging (and re-emerging) pathogens that are likely to cause severe outbreaks in the near future and for which few or no medical countermeasures exist (GPP-EP),” World Health Organization, Geneva, 2016.
 
[36]  WHO, “Good Participatory Practice for COVID-19: a toolbox,” World Health Organization, Geneva, 2020.
 
[37]  NIA-NIH, “What Are Clinical Trials and Studies?,” National Institute on Ageing, 9 April 2020. [Online]. Available: https://www.nia.nih.gov/health/what-are-clinical-trials-and-studies. [Accessed 25 November 2020].
 
[38]  WHO-AFRO, “The African Vaccine Regulatory Forum (AVAREF),” World Health Organization, https://www.afro.who.int/health-topics/immunization/avaref.
 
[39]  W. SR, “National routine adult immunization programs among World Health Organization member states: an assessment of health systems to deploy future SARS-CoV-2 vaccines.,” MedRxiv 2020, Dec 16, 2020.
 
[40]  S. L. Wilson and C. Wiysonge, “Social media and vaccine hesitancy,” BMJ Global Health, 23 October 2020.
 
[41]  M. Schuster, Eskola and P. Duclos, “SAGE Working Group. Review of Vaccine Hesitancy: Rationale, Remit, and Methods.,” Vaccine. pp. 33(34):4157-4160, 2015.
 
[42]  CDC, “CDC. Flu vaccination coverage, United States, 2018–19 Influenza Season. 2019.,” https ://www.cdc.gov/flu/fluva xview /cover age-1819e stima tes.htm. Accessed 3 Apr 2020, 2019.
 
[43]  N. MacDonald, “Vaccine hesitancy: Definition, Scope and Determinants.,” Vaccine, pp. 33(34): 4161-4164., 2015.
 
[44]  H. Larson, C. Jarrett, E. Eckersberger, D. Smith and P. Paterson, “Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: A systematic review of published literature, 2007-2012.,” Vaccine, pp. 32(19): 2150-9., 2014.
 
[45]  E. Dubé, C. Laberge, M. Guay, P. Bramadat and R. Roy, “Vaccine Hesitancy: An Overview.,” Human vaccines & immunotherapeutics., pp. 9(8):1763-73, 2013.
 
[46]  H. Larson, W. Schulz, J. Tucker and D. Smith, “Measuring Vaccine Confidence: Introducing a Global Vaccine Confidence Index.,” PLoS currents. p. 7, 2015.
 
[47]  M. O. Folayan and B. Haire, “History, Culture, and Social Norms: Implications for Ebola Drug and Vaccine Clinical Trials,” MIT Press, https://covid-19.mitpress.mit.edu/pub/to7msdih/release/1, 2016.
 
[48]  P. O. O. Tindana,, N. Kass and P. Akweongo, “The informed consent process in a rural African setting: A case study of the Kassena-Nankana district of Northern Ghana,” IRB Ethics and Human Research, 2006.
 
[49]  A. Powell, “Vaccine close, but it likely won’t be a silver bullet,” The Harvard Gazette: Health and Mdicine, https://news.harvard.edu/gazette/story/2020/11/fauci-and-paul-farmer-see-slow-process-ahead-in-covid-battle/, 2020.