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American Journal of Medical Sciences and Medicine. 2018, 6(2), 45-50
DOI: 10.12691/ajmsm-6-2-6
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Liver Enzyme Abnormalities: A Comparative Study between Treatment Naïve HIV and HIV Negative Hospital Patients

Ganiyat Oyeleke1, and Anele Ihekwaba2

1Lagos University Teaching Hospital, Lagos State, Nigeria

2University of Port Harcourt Teaching Hospital, Rivers State, Nigeria

Pub. Date: November 09, 2018

Cite this paper:
Ganiyat Oyeleke and Anele Ihekwaba. Liver Enzyme Abnormalities: A Comparative Study between Treatment Naïve HIV and HIV Negative Hospital Patients. American Journal of Medical Sciences and Medicine. 2018; 6(2):45-50. doi: 10.12691/ajmsm-6-2-6


Background and Aims: The prevalence of People living with human Immunodeficiency virus remains considerably high in Nigeria. Liver disease has emerged as an increasingly significant contributor to mortality among HIV-infected patients. The aim of our study was to compare the difference in the prevalence of liver enzyme abnormalities between treatment naïve HIV positive and HIV negative patients. Method: The study was conducted at a teaching hospital. The study population consists of 736 patients (368 cases and 368 controls) that were selected from the hospital. The cases were treatment naïve HIV patients and the controls were patients being managed for other diseases. A diagnosis of liver disease was made based on the diagnostic criteria which include; presence of at least one clinical feature of liver disease, two liver chemistry abnormalities and an abnormal hepatic ultrasound report. Result: The mean ages of the cases and controls were 35.97±9.77 and 36.08±9.54 years respectively. Liver disease was seen in 277 (75.3%) of the cases and 54 (14.7%) of the controls, this difference was statistically significant (p<0.001). Alkaline phosphatase ALP (p<0.001) and Gamma-glutamyl transferase GGT (p=0.04) were indicative of the presence of liver diseases in univariate analysis. Although Bilirubin was not of statistical significance, all HIV infected patients with total bilirubin ≥ 25.5µmol/L had liver diseases. Conclusion: The use of abnormal liver enzymes and clinical features in resource poor settings are valuable screening tools to indicate the presence of liver diseases particularly in HIV – infected patients.

liver enzyme abnormalities HIV treatment naïve HIV patients Nigeria

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