Linezolid Induced Black Hairy Tongue an Uncommon Phenomenon: A Case Report with Update of Review of Literature

Rakesh Tilak Raj^1, , Rajnish Raj², Jitender Nagpal² and Raj Kumar³

¹Department of Dermatology and Venereology and Leprosy, Government Medical College and Rajindra Hospital, Patiala, India

²Department of Psychiatry, Government Medical College and Rajindra Hospital, Patiala, India

³Department of Pharmacology, GGS Medical College (Baba Farid University of Health Sciences), Faridkot, India

Cite this paper:
Rakesh Tilak Raj, Rajnish Raj, Jitender Nagpal and Raj Kumar. Linezolid Induced Black Hairy Tongue an Uncommon Phenomenon: A Case Report with Update of Review of Literature. American Journal of Medical Sciences and Medicine. 2016; 4(4):71-76. doi: 10.12691/ajmsm-4-4-1

Abstract

As the use of newer antibiotics like Linezolid is tremendously increasing due to their efficacy and safety against methicilin resistant staphylococcus aureus and Vancomycin resistant entero-cocci, its rarer side effect like black hairy tongue is often overlooked. Case presentation: A 26 year-old-male, reported with asymptomatic black hairy tongue (BHT) on tenth day after taking Linezolid 600mg twice daily for his left foot infection. His tongue examination was consistent with black hairy tongue. He neither exhibited any predisposing factor nor any history of substance abuse or drug except Linezolid and prompt withdrawal of drug led to complete resolution of BHT on seventh day. Re-challenge test revoked similar response on tenth day. WHO-UMC causality scale showed certain adverse drug reaction and on Naranjo’s adverse drug reaction probability scale score of 10 indicates definite association. Conclusion: This case report is highlighted due to its rarity, self-limiting and reversible condition. The purpose of the paper is to create awareness amongst medical fraternity about Linezolid induced Adverse Drug Reaction.

Keywords:
Oxazolidinone Naranjo’s algorithm adverse event Linezolid Lingua villosa nigra DSM-5 HADS

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