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American Journal of Medical Sciences and Medicine. 2016, 4(3), 50-52
DOI: 10.12691/ajmsm-4-3-1
Open AccessCase Report

Gastric Xanthelasma: A Report of Two Cases with Review of Literature

Mazaher Ramezani1, Seyed-Jafar Navabi2, Atena Azami1 and Masoud Sadeghi3,

1Department of Pathology, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Pub. Date: April 22, 2016

Cite this paper:
Mazaher Ramezani, Seyed-Jafar Navabi, Atena Azami and Masoud Sadeghi. Gastric Xanthelasma: A Report of Two Cases with Review of Literature. American Journal of Medical Sciences and Medicine. 2016; 4(3):50-52. doi: 10.12691/ajmsm-4-3-1


Background: Gastric xanthelasmas are rare lesions. The lesions are frequently located in the stomach and less common sites are esophagus, duodenum and the colon. Case Presentation: We reported two cases in this study. A 50-year-old man with a past medical history of diabetes mellitus applied with dysphagia and upper gastrointestinal endoscopy revealed a yellow plaque (10×10mm) on the gastric mucosa of cardiac part and during biopsy is easily picked. Histopathological examination of the plaque excluded gastric cancer and revealed numerous large polygonal cells with abundant foamy cytoplasm. A 60-year-old man attended hospital with abdominal pain radiating to the back that there was a 3×2mm yellowish-white plaque in the antrum of the stomach. Histopathological examination of the gastric mucosa in the antrum showed mild chronic gastritis and some H.pylori-like microorganisms. Also, aggregates of foamy macrophages were presented. Conclusions: Although the clinical significance of gastric xanthelasmas are unclear, similarities with malignancies and association with premalignant lesions, we need to pay attention to diagnosis of xanthelasmas. A biopsy is mandatory and it is advisable to use histochemical and immunohistochemical methods to confirm the diagnosis of xanthelasmas and eliminate the possibility of gastric malignancy.

gastric xanthelasmas case report histopathology

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