American Journal of Medical Sciences and Medicine
ISSN (Print): 2327-6681 ISSN (Online): 2327-6657 Website: Editor-in-chief: Apply for this position
Open Access
Journal Browser
American Journal of Medical Sciences and Medicine. 2016, 4(2), 47-49
DOI: 10.12691/ajmsm-4-2-5
Open AccessCase Report

Pulmonary Involvement of Diffuse Large B-cell Lymphoma with Cavitary Lesions

İskender Kara1, , Fatma Yıldırım2, Ebru Berber3, Ramazan Öcal4, Zeynep Arzu Yeğin4, Melda Türkoglu3 and Gülbin Aygencel3

1Gazi University Faculty of Medicine, Department of Anesthesiology and Reanimation, Intensive Care Fellowship Program, Ankara, Turkey

2Gazi University Faculty of Medicine, Department of Pulmonary Medicine, Intensive Care Fellowship Program, Ankara, Turkey

3Gazi University Faculty of Medicine, Department of Internal Medicine, Intensive Care Unite, Ankara, Turkey

4Gazi University Faculty of Medicine, Department of Hematology, Ankara, Turkey

Pub. Date: April 09, 2016

Cite this paper:
İskender Kara, Fatma Yıldırım, Ebru Berber, Ramazan Öcal, Zeynep Arzu Yeğin, Melda Türkoglu and Gülbin Aygencel. Pulmonary Involvement of Diffuse Large B-cell Lymphoma with Cavitary Lesions. American Journal of Medical Sciences and Medicine. 2016; 4(2):47-49. doi: 10.12691/ajmsm-4-2-5


Diffuse large B-cell lymphoma (DLBCL) is the most common type of extranodal lymphoma. Typically disease occurs fastly growing nodal or extranodal masses with systemic symptoms. Pulmonary involvement may also occur in DLBCL. Here we present a DLBCL with cavitary lesions in the lung. A 59-year-old male was diagnosed with DLBCL through an endoscopic gastric biopsy that was performed 1.5 years ago. After six course of R-CHOP chemotherapy, the relaps of disease was confirmed with mediastinoscopy. Despite two courses of RICE chemotherapy and one course of R-BAB therapies, the patient was admitted to the intensive care unit with shortness of breath and tachypnea. Thorax computed tomography showed a mass lesion that enclosed and narrowed the right major bronchus and multiple lesions with cavitation. The infections were excluded with bronchoscopy. The patient received pulse steroid therapy, radiotherapy and three courses of Hyper-CVAD chemotherapy. In the control thorax CT, cavitary lesions got smaller, respiratory insufficiency of patient improved. When pulmonary cavitary lesions are observed in patients under follow-up with the diagnosis of lymphoma, the pulmonary involvement of lymphoma should also be considered in addition to the infectious agents.

diffuse large B-cell lymphoma pulmonary cavitary lesion

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


Figure of 3


[1]  Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A et al. Diffuse large B-cell lymphoma. Critical Reviews in Oncology/Hematology 2013; 87; 146-171.
[2]  Friedberg JW. Diffuse Large B-Cell Lymphoma. Hematol Oncol Clin North Am. 2008 October; 22(5): 941.
[3]  Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon: International Agency for Research on Cancer, 2008.
[4]  Al Diab AR, Aleem A, Qayum A, Al Askar AS, Ajarim DS. Clinico-Pathological Pattern of Extranodal Non-Hodgkin’s Lymphoma in Saudi Arabia. Asian Pacific Journal of Cancer Prevention. 2011, Vol:12.
[5]  Fisher SG, Fisher RI. The epidemiology of non-Hodgkin’s lymphoma. Oncogene 2004; 23(38): 6524-34.
[6]  Ferhanoğlu B. Erişkinlerde Lenfomalar. İ.Ü. Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri. Sempozyum Dizisi No:45, Kasım 2005; 209-248.
[7]  López-Guillermo A, Colomo L, Jiménez M et al. Diffuse Large B-Cell Lymphoma: Clinical and Biological Characterization and Outcome According to the Nodal or Extranodal Primary Origin. Journal of Clinical Oncology 2005; Vol:23, No:12.
[8]  Kim JH, Lee SH, Park J, Kim HY et al. Primary Pulmonary Non-Hodgkin’s Lymphoma. Jpn J Clin Oncol 2004; 34(9); 510-514.
[9]  Hare SS, Souza CA, Baın G, Seely JM et al. Review Article. The radiological spectrum of pulmonary lymphoproliferative disease. The British Journal of Radiology, 85(2012), 848-864.
[10]  Kaya A, Kaya S, Çelik G, Özdemir Ö, Doğaner A. Approach to Patients with cavitary lung disease.T Klin J Med Sci 1997, 17:413-418.
[11]  Erbaycu AE, Aksel N, Çakan A, Özsöz A, Soy Ö. Contribution of Thoracic Computed Tomography to Differential Diagnosis in Cavitary Pulmonary Disease. Turkish Thoracic Journal 2003;4(1):43-47.
[12]  Gadkowski LB and Stout JE. Reviews, Cavitary Pulmonary Disease. Clinical Microbiology. 2008; 21(2): 305-333.
[13]  Ryuand JH, Swensen SJ. Review Cystic and Cavitary Lung Diseases: Focal and Diffuse. Mayo Clin Proc. 2003; 78: 744-752.