American Journal of Medical Sciences and Medicine
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American Journal of Medical Sciences and Medicine. 2016, 4(2), 47-49
DOI: 10.12691/ajmsm-4-2-5
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Pulmonary Involvement of Diffuse Large B-cell Lymphoma with Cavitary Lesions

İskender Kara1, , Fatma Yıldırım2, Ebru Berber3, Ramazan Öcal4, Zeynep Arzu Yeğin4, Melda Türkoglu3 and Gülbin Aygencel3

1Gazi University Faculty of Medicine, Department of Anesthesiology and Reanimation, Intensive Care Fellowship Program, Ankara, Turkey

2Gazi University Faculty of Medicine, Department of Pulmonary Medicine, Intensive Care Fellowship Program, Ankara, Turkey

3Gazi University Faculty of Medicine, Department of Internal Medicine, Intensive Care Unite, Ankara, Turkey

4Gazi University Faculty of Medicine, Department of Hematology, Ankara, Turkey

Pub. Date: April 09, 2016

Cite this paper:
İskender Kara, Fatma Yıldırım, Ebru Berber, Ramazan Öcal, Zeynep Arzu Yeğin, Melda Türkoglu and Gülbin Aygencel. Pulmonary Involvement of Diffuse Large B-cell Lymphoma with Cavitary Lesions. American Journal of Medical Sciences and Medicine. 2016; 4(2):47-49. doi: 10.12691/ajmsm-4-2-5

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common type of extranodal lymphoma. Typically disease occurs fastly growing nodal or extranodal masses with systemic symptoms. Pulmonary involvement may also occur in DLBCL. Here we present a DLBCL with cavitary lesions in the lung. A 59-year-old male was diagnosed with DLBCL through an endoscopic gastric biopsy that was performed 1.5 years ago. After six course of R-CHOP chemotherapy, the relaps of disease was confirmed with mediastinoscopy. Despite two courses of RICE chemotherapy and one course of R-BAB therapies, the patient was admitted to the intensive care unit with shortness of breath and tachypnea. Thorax computed tomography showed a mass lesion that enclosed and narrowed the right major bronchus and multiple lesions with cavitation. The infections were excluded with bronchoscopy. The patient received pulse steroid therapy, radiotherapy and three courses of Hyper-CVAD chemotherapy. In the control thorax CT, cavitary lesions got smaller, respiratory insufficiency of patient improved. When pulmonary cavitary lesions are observed in patients under follow-up with the diagnosis of lymphoma, the pulmonary involvement of lymphoma should also be considered in addition to the infectious agents.

Keywords:
diffuse large B-cell lymphoma pulmonary cavitary lesion

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