American Journal of Medical Sciences and Medicine
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American Journal of Medical Sciences and Medicine. 2013, 1(6), 110-113
DOI: 10.12691/ajmsm-1-6-3
Open AccessArticle

Fetal Nasal Bone Length in the Period of 11 and 15 Weeks of Pregnancy in the Filipino Population

Leodoro J. Labrague1, and Lynette C. Tan2

1Samar State University, Philippines

2University of Santo Tomas, Manila, Philippines

Pub. Date: December 23, 2013

Cite this paper:
Leodoro J. Labrague and Lynette C. Tan. Fetal Nasal Bone Length in the Period of 11 and 15 Weeks of Pregnancy in the Filipino Population. American Journal of Medical Sciences and Medicine. 2013; 1(6):110-113. doi: 10.12691/ajmsm-1-6-3


In the recent years, sonographic images of fetal nose have gained popularity in detecting trisomy 21 and other aneuploidies. Reference values for nasal bone length have been reported in different countries and ethnic populations. However, there was no reference range for the fetal nasal bone length (NBL) in the Filipino population. This prospective, cross-sectional study was conducted to establish reference values for the nasal bone length (NBL) at 11 – 15 weeks of gestation in the Filipino population. Ultrasonographic visualization of 74 fetuses at 11th to 15th week gestation was carried out during the months of August 2010 to January 2011. Fetal nasal bone was measured through sagittal section of the fetal profile. Fetal nasal bone length measurement was successfully performed in all 74 cases. The mean nasal bone lengths were 1.97 mm, 2.37 mm, 2.90 mm, 3.49 mm, and 4.05 mm between 11th, 12th, 13th, 14th, and 15th gestational weeks respectively. Nasal bone length increased linearly with advancing gestational age (GA) and crown rump length (CRL). Despite of the limitations posed by this investigation, reference values for the nasal bone length (NBL) at 11 – 15 weeks of gestation in the Filipino population was identified.

fetal nasal bone ultrasound trisomy 21 Down syndrome First-trimester screening

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[1]  Cuckle HS, Wald NJ, Lindenbaum RH. Maternal serum alpha-fetoprotein measurement: a screening test for Down syndrome. Lancet 1984; 1: 926-929.
[2]  Wald NJ, Cuckle HS, Densem JW, et al. Maternal serum screening for Down's syndrome in early pregnancy. BMJ 1988; 297: 883-887.
[3]  Snijders, R. J., Noble, P., Sebire, N., Souka, A., &Nicolaides, K. H. UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Fetal Medicine Foundation First Trimester Screening Group. Lancet 1998; 352(9125), 343.
[4]  Cicero, S., Curcio, P., Papageorghiou, A., Sonek, J., &Nicolaides, K. Absence of nasal bone in fetuses with trisomy 21 at 11-14 weeks of gestation: an observational study. The lancet 2001; 358 (9294), 1665-1667.
[5]  Labrague, L.J. Expectant management in dichorionicdiamnionic twin pregnancy discordant for anencephaly. Standard Scientific Research and Essays 2013; 1(8):164-167.
[6]  Otaño L, Aiello H, Igarzábal L, Matayoshi T, Gadow EC. Association between first trimester absence of fetal nasal bone on ultrasound and Down syndrome. PrenatDiagn 2002; 22:10, 930-2.
[7]  Orlandi, F., Bilardo, C. M., Campogrande, M., Krantz, D., Hallahan, T., Rossi, C., &Viora, E. Measurement of nasal bone length at 11-14 weeks of pregnancy and its potential role in Down syndrome risk assessment. Ultrasound in obstetrics & gynecology 2003; 22:1, 36-39.
[8]  Keeling, J. W., Hansen, B. F., &Kjaer, I. Pattern of malformations in the axial skeleton in human trisomy 21 fetuses. American journal of medical genetics 1998; 68:4, 466-471.
[9]  Moon, M. H., Cho, J. Y., Lee, Y. M., Lee, Y. H., Yang, J. H., Kim, M. Y., & Park, S. H.Nasal bone length at 11–14 weeks of pregnancy in the Korean population. Prenatal diagnosis 2006; 26:6, 524-527.
[10]  Casasbuenas, A., Wong, A. E., & Sepulveda, W. First‐trimester nasal bone length in a normal Latin American population. Prenatal diagnosis 2009; 29:2, 108-112.
[11]  Sutthibenjakul, S., Suntharasaj, T., Suwanrath, C., Kor-anantakul, O., &Geater, A. A Thai reference for normal fetal nasal bone length at 15 to 23 weeks’ gestation. Journal of Ultrasound in Medicine 2009; 28:1, 49-53.
[12]  Yayla, M., Ergin, R. N., &Göynümer, G. Normative values of fetal nasal bone lengths of Turkish singleton pregnancies in the first trimester. Journal of the Turkish-German Gynecological Association 2011; 12.
[13]  Prefumo F, Sairam S, Bhide A, Penna L, Hollis B, Thilaganathan B. Maternal ethnic origin and fetal nasal bone at 11-14 weeks of gestation. BJOG 2004; 111:109-112.
[14]  Cossi, P.S, Junior, E.A., Bussamra, L.C., Filho, H.A., Nardazzo, L.M., Moron, A.F. Measurement of fetal nasal bone length in the period between 11 and 15 gestational weeks in a Brazilian population: a preliminary study. Radiol Bras 2008; 41:3, 155-158.
[15]  Collado, F., Bombard, A, Li, V., et al. Ethnic variation of fetal nasal bone length between 11 – 14 weeks’ gestation. PrenatDiagn 2006; 26, 703-7
[16]  Chen M, Lee CP, Tang MH. First trimester examination of fetal nasal bone in the Chinese population. PrenatDiagn 2006;26, 524 – 7.
[17]  Cusick, MD, Provenzano J, Sullivan CA, Gallousis FM, Rodis JF. Fetal nasal bone length in Euploid and Aneuploid fetuses between 11 and 20 weeks gestation. J ultrasound Med. 2004; 23:1327 – 1333
[18]  Suwanrath et al.: Reliability of fetal nasal bone length measurement at 11–14 weeks of gestation. BMC Pregnancy and Childbirth 2013 13:7.