American Journal of Medical Sciences and Medicine
ISSN (Print): 2327-6681 ISSN (Online): 2327-6657 Website: http://www.sciepub.com/journal/ajmsm Editor-in-chief: Apply for this position
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American Journal of Medical Sciences and Medicine. 2019, 7(3), 60-63
DOI: 10.12691/ajmsm-7-3-2
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Silicosis: Origins and Consequences

Diemen Delgado Garcia1, , Patricio Rivera Latorre2, Nayab Mahmood Sultan3, Oscar Ramirez Yerba4, Enmanuel Agila Palacios5 and Ashley Delgado Cano6

1University of Guadalajara, Researcher, Research Institute for Safety and Health at Work, Guadalajara, Mexico

2University of Chile, Professor of Chemistry, Faculty of Sciences, Santiago, Chile

3Silicosis Research, Technical Program Lead, Vancouver, Canada

4Scientific University of the South, Researcher of the Postgraduate of Occupational Medicine and the Environment, Lima, Peru

5University of the Armed Forces of Ecuador, Faculty of Security and Risks, Quito, Ecuador

6Universidad Andres Bello, Medical student, Viña del Mar, Chile

Pub. Date: September 10, 2019

Cite this paper:
Diemen Delgado Garcia, Patricio Rivera Latorre, Nayab Mahmood Sultan, Oscar Ramirez Yerba, Enmanuel Agila Palacios and Ashley Delgado Cano. Silicosis: Origins and Consequences. American Journal of Medical Sciences and Medicine. 2019; 7(3):60-63. doi: 10.12691/ajmsm-7-3-2

Abstract

Silicosis is a lung disease caused by the inhalation of silica dust and the consequent depositing of this inorganic material in the bronchi, lymph nodes, and/or lung parenchyma, with or without, associated respiratory dysfunction. Silicosis is an irreversible disease. Chest digital radiography is considered as one of the greatest technological advances in imaging systems beneficial in the identification of Silicosis. The diagnostic basis of silicosis is the radiological finding of diffuse lung opacities, associated with the history of inhalation of silica dust or one of its several polymorphs. Occupational history forms a major component in the investigation process along with the finding of diffuse pulmonary nodules. The application of adequate dust control measures in work environments allows workers to prevent or control exposures thus avoiding or limiting the potential for the disease. Among the challenges of how we should address this public health problem, is to raise awareness among key stakeholders engaged in the working environment about the magnitude of the health problem caused by Silicosis.

Keywords:
silica silicosis radiology prevention

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Leung CC, Yu IT, Chen W. Silicosis. The Lancet. 2012; 379 (9830); 2008-18.
 
[2]  Chan JYW, et al. RNA-Seq revealed ATF3-regulated inflammation induced by silica. Toxicology. 2018; 393: 34-41.
 
[3]  Skuland T, Ovrevik J, Lag M, Refsnes M. Role of size and surface area for pro-inflammatory responses to silica nanoparticles in epithelial lung cells: importance of exposure conditions. Toxicol In Vitro. 2014; 28(2):146-55.
 
[4]  Li X, et al. Bone marrow mesenchymal stem cells attenuate silica-induced pulmonary fibrosis via paracrine mechanisms. Toxicology Letters. 2017; 270: 96-107.
 
[5]  Delgado García, Diemen. Silicosis: Controversy in detection. Med Segur Trab. 2014; 60(234): 4-8.
 
[6]  Occupational Safety and Health. Guidelines for the use of the ILO International Classification of Radiographs of Pneumoconiosis. 2011 ed. rev. Geneva: International Labour Organization; 2011.
 
[7]  Masoud Zare Naghadehi, Farhang Sereshki, F. Mohammadi. Pathological study of the prevalence of silicosis among coal miners in Iran: A case history. Atmospheric Environment. 2014; 83: 1-5.
 
[8]  Sultan, Nayab. The Silent Killer. Solids and Bulk Handling. 2017; 3: 17-8.
 
[9]  Garcia, D.D., Sultan, N. M., Yerba, O.R., Castro, S.J., Palacios, E.A., Cano, A.D. Silicosis and Smoking: Intrinsic Phenomenon in the Respiratory System. Advances in Applied Sociology. 2018; 8:659-667.
 
[10]  LI Juan, et al. Crystalline Silica Promotes Rat Fibrocyte Differentiation in Vitro, and Fibrocytes Participate in Silicosis in Vivo. Biomedical and Environmental Sciences. 2017; 30(9): 649-60.
 
[11]  Rimal B, Greenberg AK, Rom WN. Basic pathogenetic mechanisms in silicosis: current understanding. Current Opinion in Pulmonary Medicine. 2005; 11(2): 169-73.
 
[12]  Delgado D, Aguilera M de los A, Delgado F, Rug A. The Experience of Miners Relocated to Alternative Positions due to Silicosis in the Andean of CODELCO, Chile, 2010. Safety and Health at Work. 2012; 3(2): 140-5.
 
[13]  SULTAN, Nayab. The Silica Dust Hazard – What is it and why should I be concerned? Canadian Design and Construction Report. 2017 8(1): 12-7.
 
[14]  Yuan J, et al. Polymorphisms in autophagy related genes and the coal workers ´ pneumoconiosis in a Chinese population. 2017; 632: 36-42.
 
[15]  Abdelaziz R, Elkashef W, Said E. Tadalafil reduces airway hyperactivity and protects against lung and respiratory airways dysfunction in a rat model of silicosis. International Immunopharmacology. 2017; 40: 530-41.
 
[16]  Deng H, et al. Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat. Toxicology and Applied Pharmacology. 2016; 294: 1-10.
 
[17]  Gardiner C, Mills K. The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases. Semin Immunol. 2016; 28: 343-50.