American Journal of Medicine Studies
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American Journal of Medicine Studies. 2019, 7(1), 1-6
DOI: 10.12691/ajms-7-1-1
Open AccessArticle

Study on the Correlation between Serum 25-Hydroxyvitamin D3 Level and Obesity

Weijuan Song1, Ting Cui1, Qiuxia Ge2 and Ruixia Yang2,

1#These authors contributed equally to this work.

2Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, National Key Clinical Department of Laboratory Medicine, Nanjing, China

Pub. Date: July 03, 2019

Cite this paper:
Weijuan Song, Ting Cui, Qiuxia Ge and Ruixia Yang. Study on the Correlation between Serum 25-Hydroxyvitamin D3 Level and Obesity. American Journal of Medicine Studies. 2019; 7(1):1-6. doi: 10.12691/ajms-7-1-1


Objective: To investigate the relationship between serum 25- hydroxyvitamin D3 [25-(OH)D3] and its related metabolic indexes in the obese. Methods: 239 obese patients, including 109 males and 130 females, were collected from the weight-loss clinic of Jiangsu People's Hospital from December 2016 to March 2018, and 221 physical examination samples, including 99 males and 122 females, were collected from physical examination Center of Jiangsu People's Hospital at the same time. The levels of 25-(OH)D3 were measured and their relationship with obesity, glycometabolism and lipid metabolism was analyzed. Results: BMI of males was significantly higher than that of females (p<0.05). There was no significant difference in the level of 25-(OH)D3 between men and women. With the increase of BMI, the level of 25-(OH)D3 showed a downward trend, with a significant difference (χ2=10.066, P < 0.05). The prevalence rate of simple obesity in 25-(OH)D3 more insufficient group was significantly lower than that in 25-(OH)D3 insufficient group (χ2=6.121, P < 0.05). Although the prevalence rate of hypertension, type 2 diabetes mellitus, hyperuricemia and hyperinsulinemia in the 25-(OH)D3 more insufficient group was higher than that in the 25-(OH)D3 insufficient group, there was no significant difference. Pearson correlation analysis showed that 25-(OH)D3 was negatively correlated with BMI (r= -0.197), C-peptide (C-P) (r= -0.134), and positively correlated with age (r= 0.168). Taking 25-(OH)D3 as dependent variable and other indexes as independent variables, multivariate linear regression analysis was performed. Age, BMI, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) were independently correlated with 25-(OH)D3 ( beta values were 0.157, -0.164, 0.513 and-0.473 respectively). Conclusion: Obesity and related metabolic abnormalities are closely related to the decrease of 25-(OH)D3. The level of 25-(OH)D3 usually decreased in obese people, and the decrease of 25-(OH)D3 will lead to metabolic abnormalities such as obesity and hypertension.

25- hydroxyvitamin D3 obesity metabolic abnormalities

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