American Journal of Microbiological Research
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American Journal of Microbiological Research. 2017, 5(2), 28-31
DOI: 10.12691/ajmr-5-2-1
Open AccessArticle

Operative Techniques, Treatment, and Precaution of Common Complications of Orthotopic Rat Liver Transplantation

Mao-Ming Tang1, Yun-Bing Wang2 and Jian-Ping Gong2,

1Department of Surgery, Wanzhou Hospital of TCM of Chongqing, Chongqing, China

2Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

Pub. Date: April 10, 2017

Cite this paper:
Mao-Ming Tang, Yun-Bing Wang and Jian-Ping Gong. Operative Techniques, Treatment, and Precaution of Common Complications of Orthotopic Rat Liver Transplantation. American Journal of Microbiological Research. 2017; 5(2):28-31. doi: 10.12691/ajmr-5-2-1


Objective This study investigates operative techniques, treatment, and precaution for common complications of orthotopic liver transplantation (OLT) in rats. Methods OLT was performed in 110 rats through modified two-cuff method. Operative techniques were concluded, and causes, treatment, and precaution of common complications were analyzed. Results In operation phase, main causes for rat death included anesthesia, airway obstruction, pneumothorax, hemorrhagic shock, long anhepatic time, and air embolism. After surgery, main causes for rat death were as follows: stoma bleeding, infection, obstruction, and necrosis of biliary tract and poor hepatic function restoration. Conclusion Improving operative techniques, modifying operative methods, and familiarizing with common complications can reduce occurrence of complications, heighten operative successful rate, and establish more stable models of OLT in rats.

liver transplantation operative technique complication rat

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