American Journal of Microbiological Research
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American Journal of Microbiological Research. 2016, 4(6), 172-177
DOI: 10.12691/ajmr-4-6-3
Open AccessArticle

Prevalence and Impact of GBV-C among HIV-1 Infected Patients under HAART in Addis Ababa, Ethiopia

Mohamed Farouk1, , Abraham Tesfaye2 and Mekuria Lakew1

1Department of Microbial Cellular & Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia

2Addis Ababa City Administration Health Research Bureaus, Addis Ababa, Ethiopia

Pub. Date: December 23, 2016

Cite this paper:
Mohamed Farouk, Abraham Tesfaye and Mekuria Lakew. Prevalence and Impact of GBV-C among HIV-1 Infected Patients under HAART in Addis Ababa, Ethiopia. American Journal of Microbiological Research. 2016; 4(6):172-177. doi: 10.12691/ajmr-4-6-3

Abstract

Hepatitis G virus or GB virus C (GBV-C) is a virus in the Flaviviridae family that does not cause any disease, but from various epidemiological observations was found to improve the clinical outcomes of HIV infection and treatment. It has the same mode of transmission with HIV. In Ethiopia, there has not been any study made on the prevalence or genotyping of GBV-C in circulation. Therefore no information is available. To fill this gap prevalence study was conducted on HIV patients under treatment. Eighty one serum samples were collected from patients on follow up study at the Addis Ababa Regional Laboratories and Research Institutes. RNA was extracted, reversed transcribed, and amplified by Real Time polymerase chain reaction (PCR), using primers for 5- untranslated region (5-UTR) of the GBV-C. Results showed 7 (8.6%) out of the 81 of HIV patients to be coinfected with GBV-C. Comparison of the mean CD4 count of the coinfected subject was found to be significantly different from the GBV-C negative patients at (P < 0.05). Further studies on clinical, immunological and genotypic analysis on larger samples are under investigation.

Keywords:
GB Virus C HIV HAART PCR HGV

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