American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2018, 6(11), 226-227
DOI: 10.12691/ajmcr-6-11-3
Open AccessCase Report

Esophageal Squamous Papilloma Associated with Human Papillomavirus

Mohamed Saad Eldin1, 2, , David Bassily1, 2, Khaled Awad1, 2 and Salah Aldergash1, 2

1Department of Internal Medicine, Temple University, Philadelphia, PA, USA

2Department of Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, PA, USA

Pub. Date: December 10, 2018

Cite this paper:
Mohamed Saad Eldin, David Bassily, Khaled Awad and Salah Aldergash. Esophageal Squamous Papilloma Associated with Human Papillomavirus. American Journal of Medical Case Reports. 2018; 6(11):226-227. doi: 10.12691/ajmcr-6-11-3


Esophageal squamous papilloma (ESP) is a rare benign tumor of the esophagus. Human papillomavirus is known to infect the genitourinary tract, the anal canal, the respiratory tract, and the skin. It is associated with benign, precancerous and cancerous lesions. Esophageal papillomas, including HPV-induced squamous cell papillomas of the esophagus, are rare, with an incidence ranging from 0.01 to 0.04 percent. We present a case of esophageal HPV induced squamous cell papilloma. A 59-year-old male presented to the clinic with epigastric abdominal pain radiating to the chest, he was treated empirically with Pantoprazole with the resolution of symptoms. The patient underwent Positron Emission Tomography (PET) scan as part of follow-up surveillance for stage IV adenocarcinoma of the lung that was resected two years ago, it showed hypermetabolic focus involving the gastroesophageal junction. Biopsy of the lesion was consistent with the involvement of human papillomavirus with no evidence of dysplasia. This case illustrates the recognizing the role of human papillomavirus in squamous cell papilloma of the esophagus and its association with GERD.

Human papillomavirus esophageal squamous papilloma GERD

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