American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
Open Access
Journal Browser
American Journal of Medical Case Reports. 2018, 6(5), 89-91
DOI: 10.12691/ajmcr-6-5-4
Open AccessArticle

Magnetic Resonance Imaging Survey of Peri-tumoral Edema of Meningioma and their Correlation with Progesterone Receptor Expression in Iranian Population

Zahra Janamiri1, , Vahid Shahmaei1 and Yousef Moghimi Boldaji2

1Department of Radiology Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Pub. Date: June 15, 2018

Cite this paper:
Zahra Janamiri, Vahid Shahmaei and Yousef Moghimi Boldaji. Magnetic Resonance Imaging Survey of Peri-tumoral Edema of Meningioma and their Correlation with Progesterone Receptor Expression in Iranian Population. American Journal of Medical Case Reports. 2018; 6(5):89-91. doi: 10.12691/ajmcr-6-5-4


Introuction: Meningiomas represent the most common primary brain tumor and comprise 3 World Health Organization (WHO) grades, the most frequent being WHO grade I (90%). In this study, we aim to investigate the prevalence and features of peri-tumoral edema of these lesions on Magnetic Resonance Imaging and their relationship with progesterone receptor (PR). Methods: From August 2011 to December 2017, we have enrolled 281 patients diagnosed with meningiomas of central nervous system, who underwent thorough imaging evaluation of diameter, size, volume and peri-tumoral edema on MRI. Of these patients, 187 patients were candidates of either surgical resection of biopsy, who were evaluated for PR by histopathological examination and immunohistochemistry (IHC) study after surgical removal. Results: Authors have found that meningiomas with higher PR positivity, represents lower volumes and also they appear as less aggressive lesions on neuroimaging. Also, we have found that meningiomas with higher PR positivity in IHC study, represents lower peri-tumoral edema on T1- and T2-weighted MRIs. On the other hand, our surgical experience showed that patients with more PR positive meningiomas, exhibit prolonged disease, with lower rate of hemorrhages. Conclusion: In this study, we have found that meningiomas with higher PR positivity, represents lower peri-tumoral edema and thus lower neurological complications; However, more advanced histopathological examination for other receptors may improve prognosis determination.

meningioma progesterone receptor magnetic resonance imaging histopathological examination

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Ibebuike, K., Ouma, J., Gopal, R., “Meningiomas among intracranial neoplasms in Johannesburg, South Africa: prevalence, clinical observations and review of the literature,” African health sciences, 13(1). 118-21. 2013.
[2]  Sughrue, M.E., Rutkowski, M.J., Aranda, D., Barani, I.J., McDermott, M.W., Parsa, A.T., “Treatment decision making based on the published natural history and growth rate of small meningiomas: a review and meta-analysis,” Journal of neurosurgery, 113(5). 1036-42. 2010.
[3]  Kim, J.H., Lee, S.H., Rhee, C.H., Park, S.Y., Lee, J.H., “Loss of heterozygosity on chromosome 22q and 17p correlates with aggressiveness of meningiomas,” Journal of neuro-oncology, 40(2). 101-6. 1998.
[4]  Wiemels, J., Wrensch, M., Claus, E.B., “Epidemiology and etiology of meningioma. Journal of neuro-oncology,” 99(3). 307-14. 2010.
[5]  Bi, W.L., Zhang, M., Wu, W.W., Mei, Y., Dunn, I.F., “Meningioma genomics: diagnostic, prognostic, and therapeutic applications,” Frontiers in surgery, 3. 40. 2016.
[6]  Rogers, L., Barani, I., Chamberlain, M., Kaley, T.J., McDermott, M., Raizer, J., Schiff, D., Weber, D.C., Wen, P.Y., Vogelbaum, M.A., “Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review,” Journal of neurosurgery, 122(1). 4-23. 2015.
[7]  Rohringer, M., Sutherland, G.R., Louw, D.F., Sima, A.A., “Incidence and clinicopathological features of meningioma,” Journal of neurosurgery, 71(5). 665-72. 1989.
[8]  Wang, S., Yang, W., Deng, J., Zhang, J., Ma, F., Wang, J., “Correlation between 99m Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy and pathological grading of meningioma,” Journal of neuro-oncology, 113(3). 519-26. 2013.
[9]  Seddighi, A.S., Seddighi, A., Behrouzian, S., Nikouei, A., “Simultaneous Presentation of Cerebellopontine Angle Pleomorphic Xanthoastrocytoma and Malignant Melanoma in a Known Case of Neurofibromatosis 1; Probable Role of BRAF Gene: A Case Report and Review of Literature,” International Journal of Cancer Management, 10(7). 2017.
[10]  Zieliński, G., Grala, B., Koziarski, A., Kozłowski, W., “Skull base secretory meningioma. Value of histological and immunohistochemical findings for peritumoral brain edema formation,” Neuroendocrinology Letters, 34(2). 2013.
[11]  Seddighi, A., Nikouei, A., Seddighi, A.S., Asadpour, M., Masoudian, N., Samaie, A., “Recent Progresses in Brain Gene Therapy,” International Clinical Neuroscience Journal, 3(4). 177-81. 2017.
[12]  Regelsberger, J., Hagel, C., Emami, P., Ries, T., Heese, O., Westphal, M., “Secretory meningiomas: a benign subgroup causing life-threatening complications,” Neuro-oncology, 11(6). 819-24. 2009.