American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2018, 6(3), 47-49
DOI: 10.12691/ajmcr-6-3-2
Open AccessArticle

Investigation of Ocular Manifestation in Patients Diagnosed with Multiple Sclerosis Based on the Manifestation and Demographic and Geographic Data

Zahra Janamiri1, , Yousef Moghimi Boldaji2 and Fardis Mosayebian1

1Department of Radiology Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Pub. Date: April 21, 2018

Cite this paper:
Zahra Janamiri, Yousef Moghimi Boldaji and Fardis Mosayebian. Investigation of Ocular Manifestation in Patients Diagnosed with Multiple Sclerosis Based on the Manifestation and Demographic and Geographic Data. American Journal of Medical Case Reports. 2018; 6(3):47-49. doi: 10.12691/ajmcr-6-3-2


Introduction: Multiple sclerosis (MS) is an autoimmune inflammatory condition which attacks and demyelinate central nervous system neurons with variable degree which causes significant disability in these patients. In this study, we plan to investigate ocular manifestation and prevalence of these symptoms in patients diagnosed with MS. Methods: We have enrolled 100 patients with confirmed diagnosis of MS, in a retrospective study from neurology clinic of a private hospital in Tehran, from 2015 to 2016. We have reviewed the thorough neurological examination and visual assessment of these patients. Also, demographic data of these patients were recorded for further analysis. We have performed statistical analysis using SPSS version 16 and Stuent T-test and Chi-square test for variables analysis. Results: Of all patients, 85 cases were female and 15 were male, with mean age of 35.2 years. We have found atrophy of the disc followed by optic neuritis in 32% and 19% respectively. Also, retrobulbar neuritis and papillitis were among less common manifestations, counting as 13% and 8% respectively. Most of the ocular manifestation were consistent with some demographic and geographic factors, such as age (most common in patients under 34 years old), female gender and patients not living in city areas. Also, patients with their disease initially started less than 22 years showed increased frequency of nystagmus and optic disc atrophy, while defect in color vision were more common in patients with initial disease initiation after 22 years old (P value < 0.05). Conclusion: Patients with MS may have various presentations of neurological abnormalities, which ocular manifestations is one of the most important and initial warning signs. We have found that optic disc atrophy and optic neuritis are among the most common presentations of MS, and neurologists should consider demographic and geographic parameters of patients.

multiple sclerosis ocular manifestation optic disc atrophy optic neuritis demographic data geographical data

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