American Journal of Medical Case Reports
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American Journal of Medical Case Reports. 2017, 5(12), 298-300
DOI: 10.12691/ajmcr-5-12-4
Open AccessCase Report

Acute Kidney Injury Associated with Sofosbuvir-Simeprevir in a Patient with Chronic Hepatitis C Virus Infection and HIV Infection: A Case Report

Yasin H1, , Mathews M1, Suh J1 and Finkel D1

1St Joseph regional medical center

Pub. Date: January 15, 2018

Cite this paper:
Yasin H, Mathews M, Suh J and Finkel D. Acute Kidney Injury Associated with Sofosbuvir-Simeprevir in a Patient with Chronic Hepatitis C Virus Infection and HIV Infection: A Case Report. American Journal of Medical Case Reports. 2017; 5(12):298-300. doi: 10.12691/ajmcr-5-12-4


Sofosbuvir and Simeprevir are new antiviral agents that have been used to treat chronic hepatitis C virus infection in the recent years with excellent virological response. Both agents are considered to have a safe renal profile. We present a 57-year-old male patient with chronic hepatitis c virus infection who developed acute kidney injury requiring hemodialysis after 7 weeks from beginning of Sofosbuvir and Simeprevir regimen. There was no renal side effects reported in clinical trials of both agents and There was only one reported case of kidney injury in patient taking Sofosbuvir in combination with Ledipasvir.

Sofosbuvir Simeprevir Hepatitis C

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