American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2017, 5(3), 56-58
DOI: 10.12691/ajmcr-5-3-3
Open AccessCase Report

Inappropriate Blood Transfusion in Neonatal Hemolytic Anemia Due to Anti-c

Falko Strotmann1, , Corinna Nöcker2, Nicole Crummenerl2, Bianca Karnuth2, Nilma Kamp2 and Gerd Hafner2

1MVZ Dr. Eberhard & Partner, Dortmund, Germany

2Zentrum für Labormedizin und Mikrobiologie, Essen, Germany

Pub. Date: March 29, 2017

Cite this paper:
Falko Strotmann, Corinna Nöcker, Nicole Crummenerl, Bianca Karnuth, Nilma Kamp and Gerd Hafner. Inappropriate Blood Transfusion in Neonatal Hemolytic Anemia Due to Anti-c. American Journal of Medical Case Reports. 2017; 5(3):56-58. doi: 10.12691/ajmcr-5-3-3


For transfusion in premature infants and newborns red blood cell (RBC) units of blood group 0, D–, and haplotype ccddee are often falsely regarded as universal compatible since they are suitable for all AB0 constellations between mother and child. In case of maternal diaplacental immunization with antibodies directed against RBC surface antigen Rhc (rare) or Rhe (very rare) these concentrates should be retained due to the risk of hemolytic disease. We report a case of immune mediated hemolytic anemia of a newborn due to antic and antiE where this restriction was not considered.

anti-c blood transfusion hemolytic disease of the fetus and newborn hemolytic anemia

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[1]  Urbaniak S. J., Greiss M. A. RhD haemolytic disease of the fetus and the newborn. Blood Reviews (2000) 14, 44-61.
[2]  Murray NA, Roberts IAG. Haemolytic disease of the newborn. Archives of Disease in Childhood Fetal and Neonatal Edition. 2007; 92(2): F83-F88.
[3]  Dajak S, Stefanović V, Capkun V. Severe hemolytic disease of fetus and newborn caused by red blood cell antibodies undetected at first-trimester screening. Transfusion 2011; 51: 1380-8.
[4]  Mollison P L, Engelfriet C P, Contreras M. Blood transfusion in clinical medicine.; Blackwell 1997
[5]  Singla S, Kumar S, Kumar RK, Sharma JB, Kachhawa G (2010) Severe hydrops in the infant of a Rhesus D positive mother due to anti-c antibodies diagnosed antenatally: a case report. J Case Rep 4: 57.
[6]  Koelewijn, J.M., Vrijkotte, T.G.M., Van Der Schoot, C.E., Bonsel, G.J. and De Haas, M. (2008), Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in the Netherlands. Transfusion, 48: 941-952.
[7]  Sheeladevi CS, Suchitha S, Manjunath GV, Murthy S. Hemolytic Disease of the Newborn Due to Anti-c Isoimmunization: A Case Report. Indian Journal of Hematology & Blood Transfusion. 2013; 29(3): 155-157.
[8]  McAdams RM, Dotzle SA, Winter LW Kerecman JD. Severe hemolytic disease of the newborn from anti-e. Journal of Perinatology (2008) 28, 230-232
[9]  Leger, RM. Positive DAT and immune-mediated hemolysis. In: Roback JD (ed). Technical manual. 17th ed. Bethesda, MD: American Association of Blood Banks, 2011:505-6.
[10]  Heddle N M, Wentworth P, Anderson D R, Emmerson D, Kelton J G, Blajchman M A. Three examples of Rh haemolytic disease of the newborn with a negative direct antiglobulin test. Transfusion Medicine. 1995; 5 113-11.
[11]  Garratty G, Telen MJ, Petz LD. Red cell antigens as functional molecules and obstacles to transfusion. Hematology AmSoc Hematol Educ Program 2002: 445-50.
[12]  Eckstein R., Zimmermann R. Immunhämatologie und Klinische Transfusionsmedizin: Theorie und Praxis Kompakt. Elsevier GmbH, 6. Auflage (2010), German language.