American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: http://www.sciepub.com/journal/ajmcr Editor-in-chief: Samy, I. McFarlane
Open Access
Journal Browser
Go
American Journal of Medical Case Reports. 2017, 5(1), 15-21
DOI: 10.12691/ajmcr-5-1-5
Open AccessCase Report

Mycoplasma Pneumoniae, an Important Differential Diagnosis of Non-Responding Pneumonia

Chaozer Er1,

1Department of General Medicine, Tan Tock Seng Hospital, Singapore

Pub. Date: February 11, 2017

Cite this paper:
Chaozer Er. Mycoplasma Pneumoniae, an Important Differential Diagnosis of Non-Responding Pneumonia. American Journal of Medical Case Reports. 2017; 5(1):15-21. doi: 10.12691/ajmcr-5-1-5

Abstract

A 24-year-old Chinese lady presented with 2 weeks of fever and 1 week of cough to us after being given antibiotic by the primary care physician. Chest-X-ray showed left sided pneumonia. She undergone computed tomography of chest and bronchoscopy to investigate the non-responding pneumonia. The final diagnosis of Mycoplasma pneumoniae pneumonia (MPP) was made after the serology result turned out to be positive. Despite having being given 11 days of macrolide, she failed to achieve clinical stability till day 13 of her admission. This case demonstrated the atypical features of MPP and the importance to consider MPP as one of the differentials of non-responding pneumonia.

Keywords:
non-responding pneumonia mycoplasma pneumoniae macrolide resistance

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Simon Finch, James D. Chalmers. Brief Clinical Review: Non-Responding Pneumonia, EMJRespir. 2014; 2: 104-111.
 
[2]  American Thoracic Society. Guidelines for the initial management of adults with community-acquired pneumonia: Diagnosis, assessment of severity, and initial antimicrobial therapy. Am J Resp Crit Care Med. 2001, 163: 1730-1754.
 
[3]  Metlay JP1, Atlas SJ, Borowsky LH, Singer DE. Time course of symptom resolution in patients with community-acquired pneumonia. Respir Med. 1998 Sep; 92(9):1137- 42.
 
[4]  Aliberti S et al. Criteria for clinical stability in hospitalised patients with community-acquired pneumonia. Eur Respir J. 2013;42(3):742-9.
 
[5]  Kashyap S, Sarkar M. Mycoplasma pneumonia: Clinical features and management. Lung India. 2010 Apr; 27(2):75-85.
 
[6]  Zhao F, Lv M, Tao X, Huang H, Zhang B, Zhang Z, Zhang J. Antibiotic sensitivity of 40 Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant isolates from Beijing, China. Antimicrob Agents Chemother. 2012 Feb;56(2):1108-9.
 
[7]  Zheng X, Lee S, Selvarangan R, Qin X, Tang YW, Stiles J, Hong T, Todd K, Ratliff AE, Crabb DM, Xiao L, Atkinson TP, Waites KB. Macrolide-Resistant Mycoplasma pneumoniae, United States.Emerg Infect Dis. 2015 Aug;21(8): 1470-2.
 
[8]  Peuchant O1, M¨¦nard A, Renaudin H, Morozumi M, Ubukata K, B¨¦b¨¦ar CM, Pereyre S. Increased macrolide resistance of Mycoplasma pneumoniae in France directly detected in clinical specimens by real-time PCR and melting curve analysis. J Antimicrob Chemother. 2009 Jul; 64(1): 52-8.
 
[9]  Suzuki S, Yamakazi T, Narita M, Okazaki N, Suzuki I, Andoh T, et al. Clinical evaluation of macrolide resistant M. pneumoniae. Antimicrob Agents Chemother. 2006;50:709-12.
 
[10]  Wiersinga WJ1, Currie BJ, Peacock SJ. Meliodosis. N Engl J Med. 2012 Sep 13;367(11):1035-44.