American Journal of Medical Case Reports
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American Journal of Medical Case Reports. 2016, 4(9), 298-300
DOI: 10.12691/ajmcr-4-9-1
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Golimumab Induced CNS, Pulmonary, and Cardiac Sarcoidosis - A Case Report and Literature Review

Zhen Wang MD1, , Eugenio Capitle MD1, Michael Jaker MD1, Smita Mahendrakar MD1 and Riju Banerjee MD1

1Internal Medicine Department, Rutgers-New Jersey Medical School, Newark, New Jersey, United States

Pub. Date: September 23, 2016

Cite this paper:
Zhen Wang MD, Eugenio Capitle MD, Michael Jaker MD, Smita Mahendrakar MD and Riju Banerjee MD. Golimumab Induced CNS, Pulmonary, and Cardiac Sarcoidosis - A Case Report and Literature Review. American Journal of Medical Case Reports. 2016; 4(9):298-300. doi: 10.12691/ajmcr-4-9-1


Tumor necrosis factor alpha (TNF-α) antagonist has been widely used in the treatment of inflammatory conditions such as rheumatoid arthritis (RA). Recently there have been case reports of the development of sarcoidosis in patients receiving TNF-α antagonists. Agents such as Infliximab, Adalimumab, and Etanercept have all been linked. However, incidents related to Golimumab, another member of the class, has not yet been described. We present the first case of Golimumab induced CNS, Pulmonary, and Cardiac sarcoidosis in a patient who presented with weakness and weight loss and was later found to have multi-organ (lung, brain, heart) sarcoid like involvement. Patient was diagnosed with seropositive (RF and CCP) RA maintained on Golimumab and Methotrexate for 2 years prior to diagnosis. Resolution of symptoms was achieved through the cessation of Golimumab and the use of systemic steroids.

sarcoidosis Golimumab Simponi TNF-α antagonist Cardiac Sarcoidosis Pulmonary Sarcoidosis CNS sarcoidosi

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