American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2016, 4(6), 221-223
DOI: 10.12691/ajmcr-4-6-10
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Rapidly Metastasizing Sarcomatoid Renal Cell Carcinoma in a 76-year Old Male

Nathaniel Moulton1, Joe Devasahayam1, , Rohini Kannuswamy1, Arul Chandran1 and Hunter Hofmann1

1Univerity of Missouri, United States

Pub. Date: July 09, 2016

Cite this paper:
Nathaniel Moulton, Joe Devasahayam, Rohini Kannuswamy, Arul Chandran and Hunter Hofmann. Rapidly Metastasizing Sarcomatoid Renal Cell Carcinoma in a 76-year Old Male. American Journal of Medical Case Reports. 2016; 4(6):221-223. doi: 10.12691/ajmcr-4-6-10


Renal Cell Carcinoma (RCC), the most lethal urological cancer has many variants. A relatively uncommon variant, sarcomatoid RCC (sRCC) is one of the most aggressive morphotypes of RCC. The complexity of this tumor is mainly due to the difficulty in its diagnosis as it can present with relatively subtle symptoms and quickly progress to very advanced stage with unusually rapid metastasis and could be fatal. We present a male patient with this rare tumor who initially presented with vague multi-system complaints. The patient rapidly deteriorated and expired following aggressive therapy and was subsequently found to have metastatic sRCC upon autopsy. We review the characteristic features of sRCC and analyze the clinical presentations, histology, prognosis as well as the atypical presentations of sRCC. This case therefore, highlights the difficulty of diagnosis prior to nephrectomy and reinforces the need for a high degree of suspicion for renal malignancies especially in the older patient.

renal cell caner pyelonephritis metastasis

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