American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: http://www.sciepub.com/journal/ajmcr Editor-in-chief: Samy, I. McFarlane
Open Access
Journal Browser
Go
American Journal of Medical Case Reports. 2016, 4(5), 158-159
DOI: 10.12691/ajmcr-4-5-3
Open AccessCase Report

In Front of Ischemic Stroke: Think about Pernicious Anemia

Ines Kechaou1, , Eya Cherif1, Imene Boukhris1, Samira Azzabi1, Chékib Kooli1, Lamia Ben Hassine1 and Narjes Khalfallah1

1Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia

Pub. Date: May 13, 2016

Cite this paper:
Ines Kechaou, Eya Cherif, Imene Boukhris, Samira Azzabi, Chékib Kooli, Lamia Ben Hassine and Narjes Khalfallah. In Front of Ischemic Stroke: Think about Pernicious Anemia. American Journal of Medical Case Reports. 2016; 4(5):158-159. doi: 10.12691/ajmcr-4-5-3

Abstract

Pernicious anemia can cause several neurologic impairment. Ischemic stroke has been reported as a rare complication of pernicious anemia. We report a case of 51-year-old woman, who presented with ischemic stroke. Hyperhomocysteinemia due to pernicious anemia was diagnosed while looking for secondary causes of the cerebral event. She was treated with vitamin B12 that improved her anemia but not her neurological impairment.

Keywords:
pernicious anemia stroke vitamine B12 homocysteine

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Andres E, Serraj K. Optimal management of pernicious anemia. J Blood Med. 2012; 3:97-103.
 
[2]  Bougteba A, Basir A, Kissani N. Recurrent ischemic stroke revealing Biermer’s disease. Rev Neurol. 2009; 165, 1099-1102.
 
[3]  LS Yashaswini, MB Patil. Stroke in a young adult secondary to vitamin B12 deficiency induced hyperhomocysteinemia. JMEDS. 2015;3:10-3.
 
[4]  Hoffman MA, Lalla E, Lu Y and al. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest. 2001; 107: 675-83.
 
[5]  Eikelboom JW, Hankey GJ, Anand SS and al. Association between high homocysteine and ischemic stroke due to large and small-artery disease but no other etiologic subtypes of ischemic stroke. Stroke. 2000;31:1069-75.
 
[6]  Kharchafi A, Oualim Z, Ameyzane T and al. Biermer’s disease and venous thrombosis. Report of two cases. Rev Med Interne. 2002; 23:563-6.
 
[7]  Malizia RW, Baumann BM, Chansky ME, Kirchhoff MA. Ambulatory dysfunction due to unrecognized pernicious anemia. J Emerg Med. 2010; 38:302-7.
 
[8]  Perros P, Singh RK, Ludlam CA, Frier BM. Prevalence of pernicious anemia in patients with type 1 diabetes mellitus and auto-immune thyroid disease. Diabet Med. 2000;17-749-751.