American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
Open Access
Journal Browser
American Journal of Medical Case Reports. 2016, 4(3), 101-107
DOI: 10.12691/ajmcr-4-3-8
Open AccessCase Study

Pulmonary Adenofibroma; A Rare Finding

Heidarali Esmaeili1, Mahzad Azimpouran1, , Behrouz Shokohi1, Elmira Mostafidi1 and Mahsa Karbasi2

1Department of General Pathology, Tabriz University of Medical Science, Tabriz, Iran

2Department of Radiology, Tabriz University of Medical Science, Tabriz, Iran

Pub. Date: April 14, 2016

Cite this paper:
Heidarali Esmaeili, Mahzad Azimpouran, Behrouz Shokohi, Elmira Mostafidi and Mahsa Karbasi. Pulmonary Adenofibroma; A Rare Finding. American Journal of Medical Case Reports. 2016; 4(3):101-107. doi: 10.12691/ajmcr-4-3-8


Pulmonary adenofibroma is a rare lung benign tumor resembling adenofibroma of the breast and genital tract. Few cases have been reported with this entity. We report a case of pulmonary adenofibroma in a 65-year-old female, which was found incidentally through the work up for her gastrointestinal problems. Chest radiograph and computed tomography scan disclosed a well circumscribed pulmonary mass at left lower lung lobe. Surgical excision was done and the specimen studied macroscopically and microscopically. Histological findings revealed a biphasic lesion showing a leaflike fibroepithelial pattern with stromal and epithelial components. Immunohistochemical studies showed positivity for pan cytokeratin (CK), CD34, vimentin, smooth muscle actin (SMA), but negative for S100 and calretinin. The patient had neither symptoms nor recurrence through one and half year follows up.

Pulmonary Lung Adenofibroma benign tumor immunohistochemistry (IHC)

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Scarff RW, Gowar FJS. Fibroadenoma of the lung. J Pathol Bacteriol 1944;56:257-9.
[2]  Butler C, Kleinerman J. Pulmonary hamartoma. Arch Pathol 1969;88:584-92.
[3]  Suster S, Moran CA. Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung. Histopathology 1993;23:547-51.
[4]  Cavazza A, Rossi G, De Marco L, Putrino I, Pellegrino S, Piana. Solitary fibrous pseudopapillary tumor of the lung: pulmonary fibroadenoma and adenofibroma revisited. Pathologica 2003;95:162-6.
[5]  Vitkovski T, Zeltsman D, Esposito M, Morgenstern N. Pulmonary adenofibroma: cytologic and clinicopathologic features of a rare benign primary lung lesion. DiagnCytopathol 2013;41:991-6.
[6]  Kumar R, Desai S, Pai T, Pramesh C.S., Jambhekar NA. Pulmonary adenofibroma: clinicopathological study of 3 cases of a rare benign lung lesion and review of the literature. Annals of Diagnostic Pathology 2014;18: 238-243.
[7]  Schirosi L, Lantuejoul S, Cavazza A, Murer B, Yves Brichon P, Migaldi M, Sartori G, Sgambato A, Rossi G. Pleuro-pulmonary solitary fibrous tumors: a clinicopathologic, Immunohistochemical, and molecular study of 88 cases confirming the prognostic value of de Perrot staging system and p53 expression, and evaluating the role of c-kit, BRAF, PDGFRs (alpha/beta), c-met, and EGFR. Am J Surg Pathol. 2008; 32(11):1627-42.
[8]  Rao N, Colby TV, Falconieri G, Cohen H, Moran CA, Suster S. Intrapulmonary solitary fibrous tumors: clinicopathologic and immunohistochemical study of 24 cases.JSurg Pathol. 2013; 37(2):155-66.
[9]  Sironi M, Rho B, Spinelli M. Adenofibromatous pattern in a solitary fibrous tumor of the lung. Int J Surg Pathol 2005;13:79.
[10]  Wang Y, Xiao HL, Jia Y, Chen JH, He Y, Tan QY, Zhang WG. Pulmonary adenofibroma in a middle-aged man: report of a case. Surg Today 2013;43: 690-3.
[11]  Varoli F, Vergani C, Caminiti R, Francese M, Gerosa C, Bongini M, et al. Management of solitary pulmonary nodule. Eur J CardiothoracSurg 2008;33:461-5.
[12]  Nicholson AG, Tomashefski JF, Popper Jr H. Hamartoma. In: Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC, editors. World Health Organization classification of tumours. Pathology and genetics of tumours of the lung, pleura, thymus and heart. Lyon: IARC Press; 2004: 113-4.
[13]  Akin O, Coskun M. Biliary adenofibroma with malignant trans-formation and pulmonary metastases: CT findings. Am J Roentgenol 2002;179:280-1.