American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: http://www.sciepub.com/journal/ajmcr Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2015, 3(12), 419-421
DOI: 10.12691/ajmcr-3-12-10
Open AccessCase Report

Atypical Myositis Presenting with Peripheral Neuropathy

Imene Boukhris1, , Samira Azzabi1, Ines kechaou1, Eya Chérif1, Anis Hariz1, Chékib Kooli1, Lamia Ben Hassine1 and Narjes Khalfallah1

1Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia

Pub. Date: December 16, 2015

Cite this paper:
Imene Boukhris, Samira Azzabi, Ines kechaou, Eya Chérif, Anis Hariz, Chékib Kooli, Lamia Ben Hassine and Narjes Khalfallah. Atypical Myositis Presenting with Peripheral Neuropathy. American Journal of Medical Case Reports. 2015; 3(12):419-421. doi: 10.12691/ajmcr-3-12-10

Abstract

Necrotizing Autoimmune Myositis (NAM) is an Acute autoimmune disease of the proximal skeletal muscle. The increased rate of morbidity and mortality in NAM is related to the severety and extant of muscle weakness. Patients with NAM develop antibodies to a specific signal recognition particle (anti-SRP ab). Peripheral neuropathy is extremely rare during the course of the disease. We report the case of a 35 y old male, hospitalized for severe proximal and distal muscle weakness with positive anti-SRB ab and concomitant peripheral neuropathy. The outcome was severe respiratory failure and death.

Keywords:
necrotizing myopathy anti-signal recognition particle (SRP) autoantibody peripheral neuropathy

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References:

[1]  Laraki R, Blétry O. Do neuromyosites exist? Ann Med Interne 1994;145:88-97.
 
[2]  Dalakas MC. Inflammatory Muscle Diseases. N Engl J Med 2015;372:1734-47.
 
[3]  Takada T, Hirakata M, Suwa A, et al. Clinical and histopathological features of myopathies in Japanese patients with anti-SRP autoantibodies. Mod Rheumatol 2009;19: 156-64.
 
[4]  Seinturier C, Labarre Villa A, Imbert B, et al. Neuropathies périphériques et myosites inflammatoires: une entité à redécouvrir ? [abstract]. Rev Med Interne 2003;24(Suppl 1):P113.
 
[5]  Vogelgesang SA, Gutierrez J, Klipple GL, et al. Polyneuropathy in juvenile dermatomyositis. J Rheumatol 1995;22:1369-72.
 
[6]  Koenig M, Fritzler MJ, Targoff IN, et al. Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes. Arthritis Res Ther 2007; 9(4): R78.
 
[7]  Casciola-Rosen L, Mammen AL. Myositis autoantibodies. Curr Opin Rheumatol 2012;24: 602-8.
 
[8]  Miller T, Al-Lozi MT, Lopate G, et al. Myopathy with antibodies to the signal recognition particle: clinical and pathological features. J Neurol Neurosurg Psychiatry 2002; 73(4):420-8.
 
[9]  Suzuki S, Hayashi YK, Kuwana M, et al. Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome. Arch Neurol 2012; 69(6):728-32.
 
[10]  Ernste FC, Reed AM. Idiopathic inflammatory myopathies: current trends in pathogenesis, clinical features, and up-to-date treatment recommendations. Mayo Clin Proc 2013; 88: 83-105.
 
[11]  Hughes RA, Swan AV, van Doorn PA. Intravenous immunoglobulin for Guillain-Barré syndrome. Cochrane Database Syst Rev. 2014 Sep 19;9:CD002063.