American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2015, 3(11), 372-373
DOI: 10.12691/ajmcr-3-11-6
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Carcinoma Causing Thrombotic Thrombocytopenic Purpura and Myelonecrosis: A Very Rare Event

Ilknur Nizam1, Mehmet Ali Erkurt1, Ilhami Berber1, Mustafa Koroglu2, Emin Kaya1, Irfan Kuku1 and Nese Karadag3

1Hematology Department, Inonu University Turgut Ozal Medical Center, Malatya, Turkey

2Karabuk University Karabuk Education and Research Hospital, Karabuk, Turkey

3Pathology Department, Inonu University Turgut Ozal Medical Center, Malatya, Turkey

Pub. Date: October 15, 2015

Cite this paper:
Ilknur Nizam, Mehmet Ali Erkurt, Ilhami Berber, Mustafa Koroglu, Emin Kaya, Irfan Kuku and Nese Karadag. Carcinoma Causing Thrombotic Thrombocytopenic Purpura and Myelonecrosis: A Very Rare Event. American Journal of Medical Case Reports. 2015; 3(11):372-373. doi: 10.12691/ajmcr-3-11-6


We report a case of thrombotic thrombocytopenic purpura (TTP) which was explored to be the clinical presentation of carcinoma. Plasma exchange therapy failed to respond for the patient, so bone marrow aspiration and biopsy were performed to find out the reason of microangiopathic hemolytic anemia. Bone marrow examination revealed non hematopoetic cell infiltration and myelonecrosis. Carcinoma metastasis was demonstrated at bone marrow trephine biopsy. The primary tumor was found at small bowel after scanning for the source of tumor by computerized tomography.

TTP malignancy plasmapheresis

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