American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2015, 3(11), 367-371
DOI: 10.12691/ajmcr-3-11-5
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A Rare Presentation of Lymphoma: Pancreatic and Thyroid Involvement

Semra Ayturk1, Mehmet Celik1, , Nuray Can2, Ebru Tastekin2, Onur Mert3, Ahmet Kucukkarda3, Atakan Sezer4, Sibel Guldiken1 and Armagan Tugrul1

1Department of Internal Medicine, Division of Endocrinology and Metabolism, Trakya Medical School , University of Trakya, Edirne, Turkey

2Department of Pathology, Trakya Medical School, University of Trakya, Edirne, Turkey

3Department of Internal Medicine, Trakya Medical School, University of Trakya, Edirne, Turkey

4Department of General Surgery, Trakya Medical School, University of Trakya, Edirne, Turkey

Pub. Date: October 14, 2015

Cite this paper:
Semra Ayturk, Mehmet Celik, Nuray Can, Ebru Tastekin, Onur Mert, Ahmet Kucukkarda, Atakan Sezer, Sibel Guldiken and Armagan Tugrul. A Rare Presentation of Lymphoma: Pancreatic and Thyroid Involvement. American Journal of Medical Case Reports. 2015; 3(11):367-371. doi: 10.12691/ajmcr-3-11-5


Primary thyroid lymphoma is a rare form of thyroid malignancies. It is usually seen in middle aged and elderly females. Its diagnosis is not always easy because it is rare and has not specific signs and symptoms. The risk of development of thyroid lymphoma is higher after Hashimoto’s thyroiditis. The most common form of thyroid lymphoma is diffuse large B cell lymphoma. Patients may present with obstructive symptoms due to progressive growth of mass. In the present report, we aimed to present a 59-year-old female patient admitted with rapidly growing neck mass, severe dyspnea, stridor and dysphagia.

thyroid lymphoma diffuse large B-cell lymphoma neck mass dyspnea stridor

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[1]  Sirota, D.K., Segal, R.L., “Primary lymphomas of the thyroid gland”, JAMA, 242(16), 1743-1746, Oct 1979.
[2]  Pedersen, R.K., Pedersen, N.T., “Primary non-Hodgkin’s lymphoma of the thyroid gland: a population based study”, Histopathology, 28(1), 25-32, Jan 1996.
[3]  Ansell, S.M., Grant, C.S., Habermann, T.M., “Primary thyroid lymphoma”, Semin Oncol, 26(3), 316-323, Jun 1999.
[4]  Ha, C.S., Shadle, K.M., Medeiros, L.J., Wilder, R.B., Hess, M.A., Cabanillas, F., Cox, J.D.,” Localized non-Hodgkin lymphoma involving the thyroid gland”, Cancer, 91(4), 629-635, Feb 2001.
[5]  Derringer, G.A., Thompson, L.D., Frommelt, R.A., Bijwaard, K.E., Heffess, C.S., Abbondanzo, S.L., “Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases”, Am J Surgical Path, 24(5), 623-639, May 2000.
[6]  Au, W.Y., Fung, A., Ma, E.S., Shek, T.W., Hawkins, B.R., Liang, R., “HLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese”, Leuk Lymph, 48(3), 531-534, Mar 2007.
[7]  Al-Marzooq, Y.M., Chopra, R., Younis, M., Al-Mulhim, A.S., Al-Mommatten, M.I., Al-Omran, S.H., “Thyroid low-grade B-cell lymphoma (MALT type) with extreme plasmacytic differentiation: report of a case diagnosed by fine-needle aspiration and flow cytometric study”, Diagn Cytopath, 31(1), 52-56, Jul 2004.
[8]  Belal, A.A., Allam, A., Kandil, A., El Husseiny, G., Khafaga, Y., Al Rajhi, N., Ahmed, G., Gray, A., Ajarim, D., Schultz, H., “Ezzat A.Primary thyroid lymphoma: a retrospective analysis of prognostic factors and treatment outcome for localized intermediate and high grade lymphoma”, Am J Clin Oncology, 24(3), 299-305, Jun 2001.
[9]  Thieblemont, C., Mayer, A., Dumontet, C., Barbier, Y., Callet-Bauchu, E., Felman, P., Berger, F., Ducottet, X., Martin, C., Salles, G., Orgiazzi, J., Coiffier, B.,” Primary thyroid lymphoma is a heterogeneous disease”, J Clin Endo Metab, 87(1), 105-111, Jan 2002.
[10]  Ansell, S.M., Habermann, T.M., Hoyer, J.D., Strickler, J.G., Chen, M.G., McDonald, T.J., “Primary laryngeal lymphoma”, Laryngoscope, 107(11), 1502-1506, Nov 1997.
[11]  Kossev, P., Livolsi, V., “Lymphoid lesions of the thyroid: review in light of the revised European-American lymphoma classification and upcoming World Health Organization classification”, Thyroid, 9(12), 1273-1280, Dec 1999.
[12]  Matsuzuka, F., Miyauchi, A., Katayama, S., Narabayashi, I., Ikeda, H., Kuma, K., Sugawara, M., “Clinical aspects of primary thyroid lymphoma : diagnosis and treatment based on our experience of 119 cases”, Thyroid , 3(2), 93-99, Summer 1993.
[13]  Onal, C., Li, Y.X., Miller, R.C., Poortmans, P., Constantinou, N., Weber, D.C., Atasoy, B.M., Igdem, S., Ozsahin, M., Ozyar, E., “Treatment results and prognostic factors in primary thyroid lymphoma patients: a Rare Cancer Network study”, Ann Oncology, 22(1), 156-164, Jan 2011.
[14]  Mikosch, P., Wurtz, F.G., Gallowitsch, H.J., Kresnik, E., Lind, P., “F-18-FDG-PET in a patient with Hashimoto's thyroiditis and MALT lymphoma recurrence of the thyroid”, Wien Med Wochenschr, 153(3-4), 89-92, 2003.
[15]  Tang, S., Huang, G., Liu, J., Liu, T., Treven, L., Song, S., Zhang, C., Pan, L., Zhang, T., “Usefulness of 18F-FDG PET, combined FDG-PET/CT and EUS in diagnosing primary pancreatic carcinoma: a meta-analysis”, Eur J Radiol , 78(1), 142-150, Apr 2011.
[16]  Austin, J.R., El-Naggar, A.K., Goepfert, H., “Thyroid cancers II: Medullary, anaplastic, lymphoma, sarcoma, squamous cell”, Otolaryngol Clin North Am, 29(4), 611-627, Aug 1996.
[17]  Green, L.D., Mack, L., Pasieka, J.L., “Anaplastic thyroid cancer and primary thyroid lymphoma: a review of these rare thyroid malignancies”, J Surg Oncol, 94(8), 725-736, Dec 2006.