American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2015, 3(11), 359-361
DOI: 10.12691/ajmcr-3-11-3
Open AccessCase Report

Atypical Manifestations of Visceral Leishmaniasis in Children

Estibaliz Valdeolmillos1, Belén Borrell1, Francisco J. Merino2, Begoña Corral3 and Cristina Calvo1,

1Department of Pediatrics, Severo Ochoa Hospital, Leganés, Madrid, Spain

2Department of Microbiology, Severo Ochoa Hospital, Leganés, Madrid, Spain

3Department of Radiology, Severo Ochoa Hospital, Leganés, Madrid, Spain

Pub. Date: October 08, 2015

Cite this paper:
Estibaliz Valdeolmillos, Belén Borrell, Francisco J. Merino, Begoña Corral and Cristina Calvo. Atypical Manifestations of Visceral Leishmaniasis in Children. American Journal of Medical Case Reports. 2015; 3(11):359-361. doi: 10.12691/ajmcr-3-11-3


Visceral leishmaniasis (VL) or kala-azar is an endemic parasitic disease caused predominantly, in its Mediterranean type, by Leishmania infantum. Fever and splenomegaly are the most common clinical manifestations, detected in more than 80% of patients. We present two cases with atypical manifestations, without fever and with spleen nodules in the context of an outbreak of VL in Spain.

visceral lesihmaniasis infants splenomegaly spleen nodule

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[1]  Ready PD. “Leishmaniasis emergence in Europe”. Euro Surveill. 10; 15(10):pii=1950. Available: PMid:20403308.
[2]  Marty P, Pomares C, Michel G, Delaunay P, Ferrua B, Rosenthal E. “Mediterranean visceral leishmaniasis”. Bull Acad Natl Med. 195 (1):181-8. Jan.2011.
[3]  Mueller YK, Kolaczinski JH, Koech T, Lokwang P, Riongoita M, Velilla E, et al. “Clinical epidemiology, diagnosis and treatment of visceral leishmaniasis in the Pokot endemic area of Uganda and Kenya”. Am J Trop Med Hyg, 90 (1):33–9. Jan.2014
[4]  Arce A, Estirado A, Ordobas M, Sevilla S, García N, Moratilla L, et al. “Reemergence of leishmaniasis in Spain: community outbreak in Madrid, Spain, 2009 to 2012”. Euro Surveill, 18 (30):20546. Jul.2013.
[5]  Cruz I, Cañavate C, Rubio JM, Morales MA, Chicharro C, Laguna F, et al. A nested polymerase chain reaction (Ln-PCR) for diagnosing and monitoring Leishmania infantum infection in patients co-infected with human immunodeficiency virus. Trans. R. Soc. Trop. Med. Hyg. 96(Suppl. 1):S185-S189. 2002.
[6]  Cruz I, Cañavete C, Rubio JM, Morales MA, Chicharro C, Laguna F, et al. Comparison of new diagnostic tools for management of pediatric mediterranean visceral leishmaniasis. J Clin Microbiol. 44(7): 2343-2347. Jul 2006.
[7]  Elmahallawy EK, Sampedro Martinez A, Rodriguez-Granger J, Hoyos-Mallecot Y, Agil A, Navarro Mari JM, et al. “Diagnosis of leishmaniasis”. J Infect Dev Ctries, 8 (8):961-72. Aug.2014.
[8]  Molina R, Jiménez MI, Cruz I, Iriso A, Martín-Martín I, Sevillano O, et al. “The hare (Lepus granatensis) as potential sylvatic reservoir of Leishmania infantum in Spain”. Vet Parasitol, 190 (1-2):268-71. Nov. 2012.
[9]  Sayyahfar S, Ansari S, Mohebali M, Behnam B. “Visceral Leishmaniasis without Fever in an 11-Month-Old Infant: a Rare Clinical. Feature of Kala-azar”. Korean J Parasitol, 52 (2): 181-91. Apr. 2014.
[10]  Mao G1, Yang G, Cheng Y, Zee CS, Huang W, Ni W, et al. “Multiple nodular lesions in spleen associated with visceral leishmaniasis: a case report of MRI-findings”. Medicine (Baltimore), 93(29):e272. Dec. 2014.
[11]  Bükte Y, Nazaroglu H, Mete A, Yilmaz F. “Visceral leishmaniasis with multiple nodular lesions of the liver and spleen: CT and sonographic findings”. Abdom Imaging, 29 (1):82-4. JanFeb. 2004.
[12]  Raeymaeckers S, Docx M, Demeyere N. “MRI-findings of nodular lesions in an enlarged spleen, associated with visceral Leishmaniasis”. Eur J Radiol, 81(10):2550-3. Oct. 2012.
[13]  Melchionda F, Varan S, Carfagnini F, Belotti T, Di Muccio T, Tigani R, et al. Spleen nodules: a potential hallmark of Visceral Leishmaniasis in young children. Melchiondaet al. BMC Infectious Disease, 14:620. 2014.
[14]  Figueras Nadal MC, García de Miguel MJ, Asensi Botet F, Velasco Bernardo R, Canals Baeza A, Ausín Aoiz I. Short course treatment for visceral leishmaniasis with liposomal amphotericin B in immunocompetent patients. An Pediatr (Barc) 59(6): 535-540. Dec 2003.