American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2015, 3(10), 319-321
DOI: 10.12691/ajmcr-3-10-4
Open AccessCase Report

Exceptional Cause of Massive Lymph Node Enlargement: Primary Localized Amyloidosis

Imene Boukhris1, , Samira Azzabi1, Ines kechaou1, Eya Chérif1, Chékib Kooli1, Nédia Znaidi2, Lamia Ben Hassine1 and Narjess Khalfallah1

1Internal Medicine Department, University hospital of Charles Nicolle, Tunis, Tunisia

2Department of Diagnostic Pathology, University hospital of Charles Nicolle, Tunis, Tunisia

Pub. Date: September 07, 2015

Cite this paper:
Imene Boukhris, Samira Azzabi, Ines kechaou, Eya Chérif, Chékib Kooli, Nédia Znaidi, Lamia Ben Hassine and Narjess Khalfallah. Exceptional Cause of Massive Lymph Node Enlargement: Primary Localized Amyloidosis. American Journal of Medical Case Reports. 2015; 3(10):319-321. doi: 10.12691/ajmcr-3-10-4


Amyloidosis is very rarely the cause of lymph node enlargement. In the localized form of the disease, amyloidosis commonly attains the bladder, the lung and the skin. Lymph node amyloid deposition is very unusual in the localized form of the disease. In particular, cervical and mediastinal sites are uncommon. We report an exceptional case of primary localized AL amyloidosis presenting as generalized lymph node enlargement. Our patient was initially treated by colchicine but in front of disease progression, a treatment with prednisone and melphalan was necessary for stabilization. Clinician should consider primary amyloidosis in the check-list of etiologies causing lymph node enlargement.

amyloidosis lymphadenopathy Localized

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