American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2015, 3(9), 288-290
DOI: 10.12691/ajmcr-3-9-7
Open AccessCase Report

Two Sub-obstructive Left Atrium Myxomasinduce Cardiac Failure after Breast Cancer Treatment

Nicolas LEDUC1, Vincent MOLINIE2 and Vincent VINH-HUNG1,

1Radiation Oncology, University Hospital of Martinique, France

2Anatomic pathology, University Hospital of Martinique, France

Pub. Date: August 20, 2015

Cite this paper:
Nicolas LEDUC, Vincent MOLINIE and Vincent VINH-HUNG. Two Sub-obstructive Left Atrium Myxomasinduce Cardiac Failure after Breast Cancer Treatment. American Journal of Medical Case Reports. 2015; 3(9):288-290. doi: 10.12691/ajmcr-3-9-7


Atrial myxoma is a rare condition. Cardiac failure after left breast cancer treatment is not usually attributed to such pathology. We describe the case of a 69 year-old female who presented two sub-obstructive left atrium myxomas one year after the end of left breast cancer treatment. Acute cardiac failure, without history of prior cardiovascular disease, could have resolved from the combination of various factors involving myxomas and complications of radiotherapy and chemotherapy. The absence of atrial images on the computerised tomography and ultrasonography performed before cancer treatment question the accuracy of diagnosis imaging as well as the actual rate of growth of cardiac myxoma.

left breast cancer atrial myxoma radiation therapy

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[1]  Roché, H., Fumoleau, P., Spielmann, M., Canon, J. L., Delozier, T., Serin, D., ... & Asselain, B. (2006). Sequential adjuvant epirubicin-based and docetaxel chemotherapy for node-positive breast cancer patients: the FNCLCC PACS 01 Trial. Journal of Clinical Oncology, 24(36), 5664-5671.
[2]  García-Quintana, A., Martín-Lorenzo, P., Suárez de Lezo, J., Díaz-Escofet, M., Llorens, R., & Medina, A. (2005). Infected left atrial myxoma. Revista Española de Cardiología (English Edition), 58(11), 1358-1360.
[3]  Walpot, J., Shivalkar, B., Rodrigus, I., Pasteuning, W. H., & Hokken, R. (2010). Atrial myxomas grow faster than we think. Echocardiography, 27(10), E128-E131.
[4]  Roudaut, R., Gosse, P., & Dallocchio, M.. (1987). Rapid growth of a left atrial myxoma shown by echocardiography. British heart journal, 58(4), 413-416.
[5]  Malekzadeh, S., & Roberts, W. C. (1989). Growth rate of left atrial myxoma. The American journal of cardiology, 64(16), 1075-1076.
[6]  Olson, R. D., & Mushlin, P. S. (1990). Doxorubicin cardiotoxicity: analysis of revailing hypotheses. The FASEB journal, 4(13), 3076-3086.
[7]  Darby, S. C., Ewertz, M., McGale, P., Bennet, A. M., Blom-Goldman, U., Brønnum, D., .. & Hall, P. (2013). Risk of ischemic heart disease in women after radiotherapy for breast cancer. New England Journal of Medicine, 368(11), 987-998.
[8]  Sengupta, P. P., Northfelt, D. W., Gentile, F., Zamorano, J. L., & Khandheria, B. K. (2008, February). Trastuzumab-induced cardiotoxicity: heart failure at the crossroads. In Mayo Clinic Proceedings (Vol. 83, No. 2, pp. 197-203). Elsevier.
[9]  Senkus-Konefka, E., & Jassem, J. (2007). Cardiovascular effects of breast cancer radiotherapy. Cancer treatment reviews, 33(6), 578-593.