American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2015, 3(9), 286-287
DOI: 10.12691/ajmcr-3-9-6
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Symmetrical Peripheral Gangrene, a Serious Complication of Sepsis

Lakshmi Kant Pathak1, , Vimala Vijayaraghavan2 and Nataliya Ana Wilson3

1Assistant Professor of Medicine, University Of North Dakota, Fargo, ND, USA

2Caribbean Medical School, Chicago Campus, Chicago, USA

3Methodist Charlton Hospital, Dallas, Texas, USA

Pub. Date: August 19, 2015

Cite this paper:
Lakshmi Kant Pathak, Vimala Vijayaraghavan and Nataliya Ana Wilson. Symmetrical Peripheral Gangrene, a Serious Complication of Sepsis. American Journal of Medical Case Reports. 2015; 3(9):286-287. doi: 10.12691/ajmcr-3-9-6


Symmetrical peripheral gangrene (SPG) is a rare but devastating complication of septicemia, with a high mortality rate. About half of the patients who survive require amputation of the affected limb. The common etiologies include both infective and non-infective etiologies. Aggravating factors include asplenia, immunosuppression, and previous cold injury to extremities, diabetes mellitus, renal failure, increased sympathetic tone and use of vasopressors. [1] SPG is defined as symmetrical distal ischemic damage at two or more sites in the absence of large vessel obstruction or vasculitis, sometimes used synonymously as purpura fulminans. Disseminated intravascular coagulation (DIC) and hemorrhagic infarction of skin with uninvolved proximal arteries are hallmark of this condition [2].

symmetrical peripheral gangrene septicemia

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[1]  CMAJ • OCT. 29, 2002; 167 (9) Symmetrical peripheral gangrene: a rare but dreadful complication of sepsis.
[2]  JAPI • VOL. 56 • JUNE 2008 R Avasthi, SC Chaudhary, KP Singh, JS Makker.
[3]  Ghosh SK, Bandyopadhyay D. Symmetrical peripheral gangrene. Indian J Dermatol Venereol Leprol 2011; 77: 244-8.