American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: http://www.sciepub.com/journal/ajmcr Editor-in-chief: Samy, I. McFarlane
Open Access
Journal Browser
Go
American Journal of Medical Case Reports. 2015, 3(6), 158-159
DOI: 10.12691/ajmcr-3-6-2
Open AccessCase Report

Severe Hemolysis as the First Manifestation of Acute Hepatitis A in an Adult with G6PD Deficiency and Positive ANA

Dhrubajyoti Bandyopadhyay1, , Adrija Hajra2, Sabyasachi Mukhopadhyay3, Vijayan Ganesan4, Manaslayek5, Debarati Bhar4, Diptak Bhowmick4, Cankatikachoudhury4 and Partha Sarathi Karmakar4

1Department of accident and emergency, Lady Hardinge Medical College, New Delhi

2Department of Internal Medicine, IPGMER, Kolkata

3RG Kar medical college, Kolkata

4Department of Internal Medicine, RG Kar Medical College, Kolkata

5Lady hardinge medical college, New delhi

Pub. Date: May 15, 2015

Cite this paper:
Dhrubajyoti Bandyopadhyay, Adrija Hajra, Sabyasachi Mukhopadhyay, Vijayan Ganesan, Manaslayek, Debarati Bhar, Diptak Bhowmick, Cankatikachoudhury and Partha Sarathi Karmakar. Severe Hemolysis as the First Manifestation of Acute Hepatitis A in an Adult with G6PD Deficiency and Positive ANA. American Journal of Medical Case Reports. 2015; 3(6):158-159. doi: 10.12691/ajmcr-3-6-2

Abstract

We report a case of hemolytic anemia as an initial manifestation of hepatitis A virus infection. On admission, the patient had anemia, reticulocytosis, and direct and indirect hyperbilirubinemia. On subsequent examination, he had both glucose-6-phosphate dehydrogenase deficiency (G6PD) and autoimmune antibodies.

Keywords:
Glucose-6-phosphate dehydrogenase deficiency (G6PD) Hepatitis A Antinuclear antibody (ANA)

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Cuthbert JA. Hepatitis A: old and new. ClinMicrobiol Rev.2001; 14:38-58.
 
[2]  Berlin T, Zandman-Goddard G, Blank M, Matthias T, Pfeiffer S,Weis I, Toubi E, Singh S, Asherson R, Fraser A, Gilburd B, SapirT, Levy Y, Lukac J, Rozman B, Kveder T, ShoenfeldY. Autoantibodies in nonautoimmune individuals during infections. Ann N Y Acad Sci. 2007; 1108: 584-593.
 
[3]  Chau TN, Lai ST, Lai JY, Yuen H.Haemolysis complicating acute viral hepatitis in patients with normal or deficient glucose-6-phosphate dehydrogenase activity. Scand J Infect Dis.1997; 29: 551-553.
 
[4]  BeutlerE.G6PD deficiency. Blood.1994; 84:3613-3636.
 
[5]  Kattamis CA, Tjortjatou F. The hemolytic process of viral hepatitis in children with normal or deficient glucose-6-phosphate dehydrogenase activity. J Pediatr. 1970; 77: 422-430.
 
[6]  Jain AK, Sircar S, Jain M, Adkar S, Waghmare C, Chahwala F.Increased morbidity in acute viral hepatitis with glucose-6-phosphate dehydrogenase deficiency. Indian Journal of Gastroenterology. 2012 August; 32(2).