American Journal of Medical Case Reports
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American Journal of Medical Case Reports. 2015, 3(3), 64-65
DOI: 10.12691/ajmcr-3-3-3
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Hypercalcemia in Advanced Prostatic Carcinoma: A Rare Event

Mary Mathews1, , Abhishek Kumar2, Nelly Awkar2, Deepak Dhaliwal1 and Michael Maroules2

1Department of Internal Medicine, St. Joseph’s Regional Medical Center, New York Medical College

2Division of Hematology Oncology, Department of Internal Medicine, St. Joseph’s Regional Medical Center

Pub. Date: January 29, 2015

Cite this paper:
Mary Mathews, Abhishek Kumar, Nelly Awkar, Deepak Dhaliwal and Michael Maroules. Hypercalcemia in Advanced Prostatic Carcinoma: A Rare Event. American Journal of Medical Case Reports. 2015; 3(3):64-65. doi: 10.12691/ajmcr-3-3-3


Prostate cancer is typically associated with metastatic osteoblastic lesions, hypocalcemia and hypophosphatemia. Hypercalcemia is a rarely encountered phenomenon i.e. 1-2% in prostate cancer, although it is well associated with other malignant cancers involving breast, lung, head, neck and multiple myelomas. We present the case of a 63 year old Mexican man with history of advanced prostatic adenocarcinoma and trans-urethral resection of prostate presented to ER with nausea, vomiting, polydipsia and altered mental status. Clinically, he appeared dehydrated and pale, with no other remarkable findings. Laboratory findings indicated severe hypercalcemia with calcium-16.1 mg/dL, with imaging studies revealing extensive metastatic osteoblastic lesions. Our patient was treated with aggressive hydration, calcitonin and pamidronic acid, his clinical status improved with complete resolution of hypercalcemia. We have discussed the possible underlying mechanisms and their interplay involved in the presentation of hypercalcemia in prostate cancer, and that its occurence is unlikely due to skeletal metastases.

prostate cancer hypercalcemia skeletal metastasis osteoblastic lesions

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