American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: http://www.sciepub.com/journal/ajmcr Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2014, 2(7), 136-138
DOI: 10.12691/ajmcr-2-7-2
Open AccessCase Report

Proteus Syndrome

Hiba Hikmat Maqdasi1,

1AL Kindy teaching Hospital, Baghdad, Iraq

Pub. Date: July 23, 2014

Cite this paper:
Hiba Hikmat Maqdasi. Proteus Syndrome. American Journal of Medical Case Reports. 2014; 2(7):136-138. doi: 10.12691/ajmcr-2-7-2

Abstract

This rare sporadic disease is named after the Greek god Proteus who could change shape. The syndrome has protean manifestations that include partial gigantism of the hands and feet, cerebriform plantar hyperplasia, hemangiomas, lipomas, lipohypoplasia, linear verrucous epidermal nevi, patchy dermal hypoplasia, macrocephaly, hyperostosis, muscular hypoplasia, and hypertrophy of the long bones.

Keywords:
dermatology proteus syndrome

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References:

[1]  Caux F, Plauchu H, Chibon F, et al. Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity. Eur J Hum Genet. 2007; 15: 767-73.
 
[2]  Happle R. The group of epidermal nevus syndromes Part I. Well defined phenotypes. J Am Acad Dermatol. 2010; 63: 1-22.
 
[3]  Johnston JJ, Finn EM, Peters K, et al. A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N Engl J Med. 2011; 365: 611-19.
 
[4]  Loffeld A, McLellan NJ, Cole T, et al. Epidermal naevus in Proteus syndrome showing loss of heterozygosity for an inherited PTEN mutation. Br J Dermatol. 2006; 154: 1194-8.
 
[5]  Loffeld A, McLellan NJ, Cole T, Moss C. Type 2 segmental Cowden disease vs. Proteus syndrome: reply from authors. Br J Dermatol. 2008; 158: 410-1.
 
[6]  Sapp JC, Turner JT, van de Kamp JM, et al. Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients. Am J Med Genet A. 2007; 143A: 2944-58.
 
[7]  Turner JT, Cohen MM Jr, Biesecker LG. Reassessment of the Proteus syndrome literature: application of diagnostic criteria to published cases. Am J Med Genet A. 2004; 130: 111-22.