American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2014, 2(1), 19-21
DOI: 10.12691/ajmcr-2-1-6
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A Rare Case of Chronic Myeloid Leukemia At a Patient with Achondroplasia

Ilknur Nizam1, , Mehmet Ali Erkurt1, Ilhami Berber1, Emin Kaya1 and Irfan Kuku1

1Department of Hematology, Faculty of Medicine, Inonu University, Malatya, Turkey

Pub. Date: January 17, 2014

Cite this paper:
Ilknur Nizam, Mehmet Ali Erkurt, Ilhami Berber, Emin Kaya and Irfan Kuku. A Rare Case of Chronic Myeloid Leukemia At a Patient with Achondroplasia. American Journal of Medical Case Reports. 2014; 2(1):19-21. doi: 10.12691/ajmcr-2-1-6


The coincidence of chronic myeloid leukemia (CML) and achondroplastic dwarfism is very rare. A 40-year old man with achondroplastic dwarfism was diagnosed with chronic myeloid leukemia in blastic phase with a Sokal index of 1.34. Standart dose imatinib treatment was immediately started after the diagnosis.

chronic myeloid leukemia achondroplasia CML achondroplastic dwarfism

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[1]  Geromin A, Sperotto A, Fanin R, Damiani D, Michieli M, Baccarani M. Bone marrow transplantation in a patient with chronic myeloid leukemia and achondroplasia. Haematologica. 1997 Nov-Dec; 82 (6): 703-4.
[2]  Karkuzhali P, Shanthi V, Usha. T A case of chronic myeloid leukaemia presenting as megakaryocytic blast crisis (AML M7) Ecancermedicalscience. 2013; 7: 375.
[3]  Van Etten RA. c-Abl regulation: a tail of two lipids. Curr Biol 2003; 13: R608.
[4]  Jabbour E, Kantarjian H: Chronic myeloid leukemia: 2012 update on diagnosis, monitoring, and management. Am J Hematol 87 (11): 1037-45, 2012.
[5]  Stoll C, Feingold J. Do Parents and Grandparents of Patients With Achondroplasia Have a Higher Cancer Risk? American Journal of Medical Genetics 130A: 165-168 (2004).
[6]  Kantarjian HM, Hochhaus A, Saglio G, et al.: Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial. Lancet Oncol 12 (9): 841-51, 2011.