American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2021, 9(12), 725-729
DOI: 10.12691/ajmcr-9-12-17
Open AccessCase Report

Dapagliflozin Induced Acute Tubulo-Interstitial Nephritis: A Case Report and Literature Review

Nida Saleem1, , Saima Bashir1, Syed Nayer Mahmud1 and Muhammad Haneef1

1Nephrology Department, Shifa International Hospital, Islamabad, 00000, Pakistan

Pub. Date: October 09, 2021

Cite this paper:
Nida Saleem, Saima Bashir, Syed Nayer Mahmud and Muhammad Haneef. Dapagliflozin Induced Acute Tubulo-Interstitial Nephritis: A Case Report and Literature Review. American Journal of Medical Case Reports. 2021; 9(12):725-729. doi: 10.12691/ajmcr-9-12-17


We report a case of an elderly male patient, who presented with acute kidney injury on background of diabetic nephropathy, secondary to dapagliflozin induced acute tubulo-interstitial nephritis requiring hemodialysis sessions. Histopathological findings are consistent with moderate tubulo-interstitial inflammation with mixed lymphocytic and eosinophilic inflammatory deposits. The patient responded well to cessation of causative medication and upon initiation of high dose steroids. The direct cause and effect relationship between dapagliflozin initiation and development of acute tubulo-interstitial nephritis is indicative of dapagliflozin being responsible for marked renal deterioration, as seen in this patient.

Acute interstitial nephritis (AIN) Diabetes dapagliflozin SGLT2 inhibitors acute kidney injury (AKI)

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